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Inhibitors of lipoprotein(a) assembly.

Sexton KE, Lee HT, Massa M, Padia J, Patt WC, Liao P, Pontrello JK, Roth BD, Spahr MA, Ramharack R. Sexton KE, et al. Among authors: spahr ma. Bioorg Med Chem. 2003 Nov 3;11(22):4827-45. doi: 10.1016/j.bmc.2002.04.001. Bioorg Med Chem. 2003. PMID: 14556799

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Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.

Franchi L, Monteleone I, Hao LY, Spahr MA, Zhao W, Liu X, Demock K, Kulkarni A, Lesch CA, Sanchez B, Carter L, Marafini I, Hu X, Mashadova O, Yuan M, Asara JM, Singh H, Lyssiotis CA, Monteleone G, Opipari AW, Glick GD. Franchi L, et al. Among authors: spahr ma. J Immunol. 2017 Apr 1;198(7):2735-2746. doi: 10.4049/jimmunol.1600810. Epub 2017 Feb 27. J Immunol. 2017. PMID: 28242647 Free PMC article.

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ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK.

Filippov S, Pinkosky SL, Lister RJ, Pawloski C, Hanselman JC, Cramer CT, Srivastava RAK, Hurley TR, Bradshaw CD, Spahr MA, Newton RS. Filippov S, et al. Among authors: spahr ma. J Lipid Res. 2013 Aug;54(8):2095-2108. doi: 10.1194/jlr.M035212. Epub 2013 May 24. J Lipid Res. 2013. PMID: 23709692 Free PMC article.

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AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism.

Pinkosky SL, Filippov S, Srivastava RA, Hanselman JC, Bradshaw CD, Hurley TR, Cramer CT, Spahr MA, Brant AF, Houghton JL, Baker C, Naples M, Adeli K, Newton RS. Pinkosky SL, et al. Among authors: spahr ma. J Lipid Res. 2013 Jan;54(1):134-51. doi: 10.1194/jlr.M030528. Epub 2012 Nov 1. J Lipid Res. 2013. PMID: 23118444 Free PMC article.

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Localization of lipoprotein(a) in a monkey model of rapid neointimal growth.

Ryan MJ, Emig LL, Hicks GW, Ramharack R, Spahr MA, Kreick JS, Brammer DW, Chien AJ, Keiser JA. Ryan MJ, et al. Among authors: spahr ma. Arterioscler Thromb Vasc Biol. 1997 Jan;17(1):181-7. doi: 10.1161/01.atv.17.1.181. Arterioscler Thromb Vasc Biol. 1997. PMID: 9012654

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CI-1011 lowers lipoprotein(a) and plasma cholesterol concentrations in chow-fed cynomolgus monkeys.

Ramharack R, Spahr MA, Sekerke CS, Stanfield RL, Bousley RF, Lee HT, Krause BK. Ramharack R, et al. Among authors: spahr ma. Atherosclerosis. 1998 Jan;136(1):79-87. doi: 10.1016/s0021-9150(97)00189-5. Atherosclerosis. 1998. PMID: 9544734

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Recombinant adenovirus vector mediated expression of lipoprotein (a) [Lp(a)] in rabbit plasma.

Ramharack R, Bocan TM, Imperiale MJ, Spahr MA. Ramharack R, et al. Among authors: spahr ma. Biochim Biophys Acta. 1999 Jun 10;1438(3):322-8. doi: 10.1016/s1388-1981(99)00065-7. Biochim Biophys Acta. 1999. PMID: 10366775

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Gemfibrozil significantly lowers cynomolgus monkey plasma lipoprotein[a]-protein and liver apolipoprotein[a] mRNA levels.

Ramharack R, Spahr MA, Hicks GW, Kieft KA, Brammer DW, Minton LL, Newton RS. Ramharack R, et al. Among authors: spahr ma. J Lipid Res. 1995 Jun;36(6):1294-304. J Lipid Res. 1995. PMID: 7666007 Free article.

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Expression of apolipoprotein[a] and plasminogen mRNAs in cynomolgus monkey liver and extrahepatic tissues.

Ramharack R, Spahr MA, Kreick JS, Sekerke CS. Ramharack R, et al. Among authors: spahr ma. J Lipid Res. 1996 Sep;37(9):2029-40. J Lipid Res. 1996. PMID: 8895068 Free article.

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Dominant negative effect of TGF-beta1 and TNF-alpha on basal and IL-6-induced lipoprotein(a) and apolipoprotein(a) mRNA expression in primary monkey hepatocyte cultures.

Ramharack R, Barkalow D, Spahr MA. Ramharack R, et al. Among authors: spahr ma. Arterioscler Thromb Vasc Biol. 1998 Jun;18(6):984-90. doi: 10.1161/01.atv.18.6.984. Arterioscler Thromb Vasc Biol. 1998. PMID: 9633941

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