Spalding DJ[au] - Search Results

Year	Number of Results
1989	2
1994	1
2000	1
2005	1
2006	7
2007	2
2008	2
2009	2
2010	1
2018	1
2022	0

1

Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP₄ receptor partial agonist for the treatment of pain.

Healy MP, Allan AC, Bailey K, Billinton A, Chessell IP, Clayton NM, Giblin GMP, Kay MA, Khaznadar T, Michel AD, Naylor A, Price H, Spalding DJ, Stevens DA, Swarbrick ME, Wilson AW. Healy MP, et al. Among authors: spalding dj. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1892-1896. doi: 10.1016/j.bmcl.2018.03.091. Epub 2018 Mar 31. Bioorg Med Chem Lett. 2018. PMID: 29636218

2

Discovery of novel biaryl heterocyclic EP1 receptor antagonists.

Hall A, Bit RA, Brown SH, Chaignot HM, Chessell IP, Coleman T, Giblin GM, Hurst DN, Kilford IR, Lewell XQ, Michel AD, Mohamed S, Naylor A, Novelli R, Skinner L, Spalding DJ, Tang SP, Wilson RJ. Hall A, et al. Among authors: spalding dj. Bioorg Med Chem Lett. 2006 May 15;16(10):2666-71. doi: 10.1016/j.bmcl.2006.02.014. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16503138

3

Impact of chronic inflammation on the pharmacokinetic-pharmacodynamic relationship of naproxen.

Huntjens DR, Spalding DJ, Danhof M, Della Pasqua OE. Huntjens DR, et al. Among authors: spalding dj. Eur J Pain. 2010 Mar;14(3):227.e1-10. doi: 10.1016/j.ejpain.2009.05.017. Epub 2009 Aug 12. Eur J Pain. 2010. PMID: 19679500

4

Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors.

Huntjens DR, Spalding DJ, Danhof M, Della Pasqua OE. Huntjens DR, et al. Among authors: spalding dj. Eur J Pain. 2009 May;13(5):448-57. doi: 10.1016/j.ejpain.2008.06.011. Epub 2008 Sep 5. Eur J Pain. 2009. PMID: 18774319

5

Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats.

Huntjens DR, Strougo A, Chain A, Metcalf A, Summerfield S, Spalding DJ, Danhof M, Della Pasqua O. Huntjens DR, et al. Among authors: spalding dj. Br J Pharmacol. 2008 Mar;153(5):1072-84. doi: 10.1038/sj.bjp.0707643. Epub 2008 Jan 14. Br J Pharmacol. 2008. PMID: 18193075 Free PMC article.

6

Correlation between in vitro and in vivo concentration-effect relationships of naproxen in rats and healthy volunteers.

Huntjens DR, Spalding DJ, Danhof M, Della Pasqua OE. Huntjens DR, et al. Among authors: spalding dj. Br J Pharmacol. 2006 Jun;148(4):396-404. doi: 10.1038/sj.bjp.0706737. Epub 2006 May 8. Br J Pharmacol. 2006. PMID: 16682968 Free PMC article.

7

Combining high-throughput pharmacokinetic screens at the hits-to-leads stage of drug discovery.

Spalding DJ, Harker AJ, Bayliss MK. Spalding DJ, et al. Drug Discov Today. 2000 Dec 1;5(12 Suppl 1):70-76. doi: 10.1016/s1359-6446(00)00061-1. Drug Discov Today. 2000. PMID: 11564569

8

Evaluation of pyrazole and ethanol induced S9 fraction in bacterial mutagenicity testing.

Burke DA, Wedd DJ, Herriott D, Bayliss MK, Spalding DJ, Wilcox P. Burke DA, et al. Among authors: spalding dj. Mutagenesis. 1994 Jan;9(1):23-9. doi: 10.1093/mutage/9.1.23. Mutagenesis. 1994. PMID: 8208127

9

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

Summerfield SG, Stevens AJ, Cutler L, del Carmen Osuna M, Hammond B, Tang SP, Hersey A, Spalding DJ, Jeffrey P. Summerfield SG, et al. Among authors: spalding dj. J Pharmacol Exp Ther. 2006 Mar;316(3):1282-90. doi: 10.1124/jpet.105.092916. Epub 2005 Dec 5. J Pharmacol Exp Ther. 2006. PMID: 16330496

10

Structure-activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists.

Hall A, Atkinson S, Brown SH, Chessell IP, Chowdhury A, Clayton NM, Coleman T, Giblin GM, Gleave RJ, Hammond B, Healy MP, Johnson MR, Michel AD, Naylor A, Novelli R, Spalding DJ, Tang SP. Hall A, et al. Among authors: spalding dj. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3657-62. doi: 10.1016/j.bmcl.2006.04.073. Epub 2006 May 11. Bioorg Med Chem Lett. 2006. PMID: 16697196

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