Springthorpe B[au] - Search Results

Year	Number of Results
1976	1
1977	1
1982	1
1990	1
2006	1
2007	2
2008	1
2012	4
2021	1
2022	0

1

The influence of drug-like concepts on decision-making in medicinal chemistry.

Leeson PD, Springthorpe B. Leeson PD, et al. Among authors: springthorpe b. Nat Rev Drug Discov. 2007 Nov;6(11):881-90. doi: 10.1038/nrd2445. Nat Rev Drug Discov. 2007. PMID: 17971784 Review.

2

Complicated embolisation of late endoleak via direct sac puncture: not all endoleaks are a type II endoleak.

Drahman A, De Boo DW, Springthorpe B, Deshpande A. Drahman A, et al. Among authors: springthorpe b. CVIR Endovasc. 2021 Jun 11;4(1):50. doi: 10.1186/s42155-021-00237-3. CVIR Endovasc. 2021. PMID: 34115223 Free PMC article.

3

The discovery of CCR3/H1 dual antagonists with reduced hERG risk.

Bahl A, Barton P, Bowers K, Brough S, Evans R, Luckhurst CA, Mochel T, Perry MW, Rigby A, Riley RJ, Sanganee H, Sisson A, Springthorpe B. Bahl A, et al. Among authors: springthorpe b. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6688-93. doi: 10.1016/j.bmcl.2012.08.124. Epub 2012 Sep 15. Bioorg Med Chem Lett. 2012. PMID: 23031591

4

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part II: optimising in vivo clearance.

Furber M, Alcaraz L, Luckhurst C, Bahl A, Beaton H, Bowers K, Collington J, Denton R, Donald D, Kinchin E, MacDonald C, Rigby A, Riley R, Soars M, Springthorpe B, Webborn P. Furber M, et al. Among authors: springthorpe b. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7707-10. doi: 10.1016/j.bmcl.2012.09.112. Epub 2012 Oct 10. Bioorg Med Chem Lett. 2012. PMID: 23116889

5

Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.

Bahl A, Barton P, Bowers K, Caffrey MV, Denton R, Gilmour P, Hawley S, Linannen T, Luckhurst CA, Mochel T, Perry MW, Riley RJ, Roe E, Springthorpe B, Stein L, Webborn P. Bahl A, et al. Among authors: springthorpe b. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6694-9. doi: 10.1016/j.bmcl.2012.08.103. Epub 2012 Sep 11. Bioorg Med Chem Lett. 2012. PMID: 23021991

6

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA. Springthorpe B, et al. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. doi: 10.1016/j.bmcl.2007.07.057. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17827008

7

Overcoming undesirable HERG potency of chemokine receptor antagonists using baseline lipophilicity relationships.

Shamovsky I, Connolly S, David L, Ivanova S, Nordén B, Springthorpe B, Urbahns K. Shamovsky I, et al. Among authors: springthorpe b. J Med Chem. 2008 Mar 13;51(5):1162-78. doi: 10.1021/jm070543k. Epub 2008 Feb 8. J Med Chem. 2008. PMID: 18257512

8

Medical problems in refugee children evacuated from South Vietnam.

Hodson EM, Springthorpe BJ. Hodson EM, et al. Among authors: springthorpe bj. Med J Aust. 1976 Nov 13;2(20):747-9. doi: 10.5694/j.1326-5377.1976.tb128274.x. Med J Aust. 1976. PMID: 1004330

9

Which hydroxy? Evidence for species differences in the regioselectivity of glucuronidation in rat, dog, and human in vitro systems and dog in vivo.

Martin IJ, Lewis RJ, Bernstein MA, Beattie IG, Martin CA, Riley RJ, Springthorpe B. Martin IJ, et al. Among authors: springthorpe b. Drug Metab Dispos. 2006 Sep;34(9):1502-7. doi: 10.1124/dmd.106.009282. Epub 2006 Jun 8. Drug Metab Dispos. 2006. PMID: 16763016

10

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part I.

Furber M, Alcaraz L, Luckhurst C, Bahl A, Beaton H, Bowers K, Collington J, Denton R, Donald D, Kinchin E, MacDonald C, Rigby A, Riley R, Soars M, Springthorpe B, Webborn P. Furber M, et al. Among authors: springthorpe b. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7702-6. doi: 10.1016/j.bmcl.2012.09.113. Epub 2012 Oct 23. Bioorg Med Chem Lett. 2012. PMID: 23142617

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