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Page 1
Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism.
Hernández IH, Cabrera JR, Santos-Galindo M, Sánchez-Martín M, Domínguez V, García-Escudero R, Pérez-Álvarez MJ, Pintado B, Lucas JJ. Hernández IH, et al. Brain. 2020 Jul 1;143(7):2207-2219. doi: 10.1093/brain/awaa150. Brain. 2020. PMID: 32533168 Free PMC article.
Here we report decreased levels of the SRSF6 interactor and regulator SREK1-another SR protein involved in RNA processing-which includes TAF1 as one of its targets. ...We show that diminishing SRSF6 through RNA interference in human neuroblastoma cells leads to a decrease …
Here we report decreased levels of the SRSF6 interactor and regulator SREK1-another SR protein involved in RNA processing-which inclu …
Biallelic variants in SREK1 downregulating SNORD115 and SNORD116 cause a Prader-Willi-like syndrome.
Saeed S, Siegert AM, Tung YCL, Khanam R, Janjua QM, Manzoor J, Derhourhi M, Toussaint B, Lam BY, Mahmoud SA, Vaillant E, Buse Falay E, Amanzougarene S, Ayesha H, Khan WI, Ramazan N, Saudek V, O'Rahilly S, Goldstone AP, Arslan M, Bonnefond A, Froguel P, Yeo GS. Saeed S, et al. J Clin Invest. 2025 Jun 22;135(16):e191008. doi: 10.1172/JCI191008. eCollection 2025 Aug 15. J Clin Invest. 2025. PMID: 40549565 Free PMC article.
Biallelic variations in SREK1 reduce SNORD115/116 expression, linking severe obesity and Prader-Willi-like traits, offering genetic and molecular insights into a new form of syndromic obesity....
Biallelic variations in SREK1 reduce SNORD115/116 expression, linking severe obesity and Prader-Willi-like traits, offering genetic a …
The rs74794265 SNP of the SREK1 Gene is Associated with COPD in Kashi, China.
Abudureheman Z, Li L, Zhong X, Xu J, Gong H, Yilamujiang S, Ren J, Xie C, Zheng A, Tuerxun D, Abudukadeer A, Aini P, Xu A, Zou X. Abudureheman Z, et al. Int J Chron Obstruct Pulmon Dis. 2021 Sep 16;16:2631-2636. doi: 10.2147/COPD.S321150. eCollection 2021. Int J Chron Obstruct Pulmon Dis. 2021. PMID: 34556983 Free PMC article.
In this study, we aimed to explore the relationship between the SNP of the SREK1 gene locus rs74794265 and the susceptibility to COPD among the Uyghur population in Kashi, XinJiang, China. ...Sanger sequencing was used to analyze the SNP of the SREK1 gene locus rs74 …
In this study, we aimed to explore the relationship between the SNP of the SREK1 gene locus rs74794265 and the susceptibility to COPD …
The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.
Chang C, Rajasekaran M, Qiao Y, Dong H, Wang Y, Xia H, Deivasigamani A, Wu M, Sekar K, Gao H, Sun M, Niu Y, Li Q, Tao L, Yan Z, Wang M, Chen S, Zhao S, Chen D, Li L, Yang F, Gao H, Chen B, Su L, Xu L, Chen Y, Seshachalam VP, Chen G, Gunaratne J, Hong W, Shi J, Chen G, Grierson DS, Chabot B, Xie T, Hui KM, Chen J. Chang C, et al. Nat Commun. 2022 Mar 16;13(1):1363. doi: 10.1038/s41467-022-29016-x. Nat Commun. 2022. PMID: 35296659 Free PMC article.
Here, we report a functional impact of a Splicing Regulatory Glutamine/Lysine-Rich Protein 1 (SREK1) variant and its regulator, Serine/arginine-rich splicing factor 10 (SRSF10). HCC patients with poor prognosis express higher levels of exon 10-inclusive SREK1 (SR …
Here, we report a functional impact of a Splicing Regulatory Glutamine/Lysine-Rich Protein 1 (SREK1) variant and its regulator, Serin …
Proteomic profile of preeclampsia in the first trimester of pregnancy.
Jacobo-Baca G, Salazar-Ybarra RA, Torres-de-la-Cruz V, Guzmán-López S, Elizondo-Omaña RE, Guzmán-López A, Vázquez-Barragán MÁ, Martínez-de-Villarreal LE. Jacobo-Baca G, et al. J Matern Fetal Neonatal Med. 2022 Sep;35(18):3446-3452. doi: 10.1080/14767058.2020.1820980. Epub 2020 Sep 21. J Matern Fetal Neonatal Med. 2022. PMID: 32957816
Nine proteins showed quantitative differences with fold-change over 1.5: PRRC2C (217.02), HEATR5A (179.46), ATP6 (162.38), PRRC2B (83.09), RBM25 (5.36), NUP205 (3.38), HLA-I (2.27), ZC3H13 (2.15), and SREK1 (1.66); and two under 0.66: Importin-4 (0.55) and Cytochrome b (0. …
Nine proteins showed quantitative differences with fold-change over 1.5: PRRC2C (217.02), HEATR5A (179.46), ATP6 (162.38), PRRC2B (83.09), R …
CXIP4 depletion causes early lethality and pre-mRNA missplicing in Arabidopsis.
Aceituno-Valenzuela UI, Fontcuberta-Cervera S, Micol-Ponce R, Sarmiento-Mañús R, Ruiz-Bayón A, Ponce MR. Aceituno-Valenzuela UI, et al. bioRxiv [Preprint]. 2024 Jun 10:2024.06.06.597795. doi: 10.1101/2024.06.06.597795. bioRxiv. 2024. Update in: Plant Physiol. 2024 Dec 24;197(1):kiae641. doi: 10.1093/plphys/kiae641. PMID: 38915646 Free PMC article. Updated. Preprint.
One of these proteins is CAX-INTERACTING PROTEIN 4 (CXIP4), which has been classified as a PTHR31437 family member, along with human SREK1-interacting protein 1 (SREK1IP1), which is thought to function in pre-mRNA splicing and RNA methylation. ...
One of these proteins is CAX-INTERACTING PROTEIN 4 (CXIP4), which has been classified as a PTHR31437 family member, along with human SREK …
Integrative weighted molecular network construction from transcriptomics and genome wide association data to identify shared genetic biomarkers for COPD and lung cancer.
Banaganapalli B, Mallah B, Alghamdi KS, Albaqami WF, Alshaer DS, Alrayes N, Elango R, Shaik NA. Banaganapalli B, et al. PLoS One. 2022 Oct 4;17(10):e0274629. doi: 10.1371/journal.pone.0274629. eCollection 2022. PLoS One. 2022. PMID: 36194576 Free PMC article.
Of these DEGs, 12 COPD hub gene-network clusters (SREK1, TMEM67, IRAK2, MECOM, ASB4, C1QTNF2, CDC42BPA, DPF3, DET1, CCDC74B, KHK, and DDX3Y) connected to dysregulations of protein degradation, inflammatory cytokine production, airway remodeling, and immune cell activity we …
Of these DEGs, 12 COPD hub gene-network clusters (SREK1, TMEM67, IRAK2, MECOM, ASB4, C1QTNF2, CDC42BPA, DPF3, DET1, CCDC74B, KHK, and …
CAX-INTERACTING PROTEIN4 depletion causes early lethality and pre-mRNA missplicing in Arabidopsis.
Aceituno-Valenzuela U, Fontcuberta-Cervera S, Micol-Ponce R, Sarmiento-Mañús R, Ruiz-Bayón A, Ponce MR. Aceituno-Valenzuela U, et al. Plant Physiol. 2024 Dec 24;197(1):kiae641. doi: 10.1093/plphys/kiae641. Plant Physiol. 2024. PMID: 39657023 Free PMC article.
This family includes human Splicing regulatory glutamine/lysine-rich protein 1 (SREK1)-interacting protein 1 (SREK1IP1), which is thought to function in pre-mRNA splicing and RNA methylation. ...
This family includes human Splicing regulatory glutamine/lysine-rich protein 1 (SREK1)-interacting protein 1 (SREK1IP1), which is tho …
Identification of circulating miRNA alterations in diabetes patients excluding periodontitis effects: insights into target gene downregulation in diabetic complications.
Lee HS, Yu Y, Kim HJ, Oh JM, Park HR, Kim YH. Lee HS, et al. Ann Med. 2025 Dec;57(1):2567609. doi: 10.1080/07853890.2025.2567609. Epub 2025 Nov 10. Ann Med. 2025. PMID: 41208460 Free PMC article.
Functional validation revealed that these genes were enriched in pathways related to glucose metabolism, cellular stress response, and tissue repair. Notably, SREK1 and GLIPR1 were commonly detected across all four tissues, suggesting potential systemic regulators of diabe …
Functional validation revealed that these genes were enriched in pathways related to glucose metabolism, cellular stress response, and tissu …
16 results