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Page 1
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy.
Capogrosso RF, Mantuano P, Uaesoontrachoon K, Cozzoli A, Giustino A, Dow T, Srinivassane S, Filipovic M, Bell C, Vandermeulen J, Massari AM, De Bellis M, Conte E, Pierno S, Camerino GM, Liantonio A, Nagaraju K, De Luca A. Capogrosso RF, et al. Among authors: srinivassane s. FASEB J. 2018 Feb;32(2):1025-1043. doi: 10.1096/fj.201700182RRR. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29097503 Free PMC article.
Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism.
Tavasoli M, Lahire S, Sokolenko S, Novorolsky R, Reid SA, Lefsay A, Otley MOC, Uaesoontrachoon K, Rowsell J, Srinivassane S, Praest M, MacKinnon A, Mammoliti MS, Maloney AA, Moraca M, Pedro Fernandez-Murray J, McKenna M, Sinal CJ, Nagaraju K, Robertson GS, Hoffman EP, McMaster CR. Tavasoli M, et al. Among authors: srinivassane s. Nat Commun. 2022 Mar 23;13(1):1559. doi: 10.1038/s41467-022-29270-z. Nat Commun. 2022. PMID: 35322809 Free PMC article.
Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy.
Heier CR, Yu Q, Fiorillo AA, Tully CB, Tucker A, Mazala DA, Uaesoontrachoon K, Srinivassane S, Damsker JM, Hoffman EP, Nagaraju K, Spurney CF. Heier CR, et al. Among authors: srinivassane s. Life Sci Alliance. 2019 Feb 11;2(1):e201800186. doi: 10.26508/lsa.201800186. Print 2019 Feb. Life Sci Alliance. 2019. PMID: 30745312 Free PMC article.
Orthogonal analysis of dystrophin protein and mRNA as a surrogate outcome for drug development.
Uaesoontrachoon K, Srinivassane S, Warford J, Mekhssian K, Montpetit H, Beauvois R, Keyhani A, Hathout Y, Yamashita T, Satou Y, Osaki H, Praest M, Moraca M, Malbasic M, Ross W, MacKinnon A, Rowsell J, Mullen A, Matyas M, Mummidivarpu S, Nagaraju K, Hoffman EP. Uaesoontrachoon K, et al. Among authors: srinivassane s. Biomark Med. 2019 Oct;13(14):1209-1225. doi: 10.2217/bmm-2019-0242. Epub 2019 Aug 5. Biomark Med. 2019. PMID: 31379197
A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia.
Tavasoli M, Feridooni T, Feridooni H, Sokolenko S, Mishra A, Lefsay A, Srinivassane S, Reid SA, Rowsell J, Praest M, MacKinnon A, Mammoliti M, Maloney AA, Moraca M, Uaesoontrachoon K, Nagaraju K, Hoffman EP, Pasumarthi KBS, McMaster CR. Tavasoli M, et al. Among authors: srinivassane s. J Biol Chem. 2022 Mar;298(3):101716. doi: 10.1016/j.jbc.2022.101716. Epub 2022 Feb 11. J Biol Chem. 2022. PMID: 35151687 Free PMC article.