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1998 1
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42 results

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Page 1
SRRM1 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by regulating the JAK/STAT signaling pathway.
Song X, Ma J. Song X, et al. Tissue Cell. 2022 Dec;79:101954. doi: 10.1016/j.tice.2022.101954. Epub 2022 Oct 12. Tissue Cell. 2022. PMID: 36270072
BACKGROUND: To explore the regulatory effect of serine/arginine repetitive matrix 1 (SRRM1) on hepatocellular carcinoma (HCC) and its potential pathway. METHODS: SRRM1 level in the tissue was tested by western blot and immunohistochemistry. ...Overexpression of S …
BACKGROUND: To explore the regulatory effect of serine/arginine repetitive matrix 1 (SRRM1) on hepatocellular carcinoma (HCC) and its …
Identification of a lactylation-related gene signature to characterize subtypes of hepatocellular carcinoma using bulk sequencing data.
Chen Y, Chang L, Hu L, Yan C, Dai L, Shelat VG, Yarmohammadi H, Sun J. Chen Y, et al. J Gastrointest Oncol. 2024 Aug 31;15(4):1636-1646. doi: 10.21037/jgo-24-405. Epub 2024 Aug 14. J Gastrointest Oncol. 2024. PMID: 39279958 Free PMC article.
Twenty LRGs (i.e., ACIN1, RAN, PPP1CB, ALDOB, SUMO2, THOC2, HDAC1, SF3A1, SF3B1, HNRNPM, PPP1CC, SRRM1, PRPF6, HDAC2, H2AFV, ALYREF, H2AFZ, H2AFX, HNRNPK, and MAGOH) were identified. ...The prognosis of the HCC patients was also predicted using a six-LRG model, comprising …
Twenty LRGs (i.e., ACIN1, RAN, PPP1CB, ALDOB, SUMO2, THOC2, HDAC1, SF3A1, SF3B1, HNRNPM, PPP1CC, SRRM1, PRPF6, HDAC2, H2AFV, ALYREF, …
A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1.
Closa A, Reixachs-Solé M, Fuentes-Fayos AC, Hayer KE, Melero JL, Adriaanse FRS, Bos RS, Torres-Diz M, Hunger SP, Roberts KG, Mullighan CG, Stam RW, Thomas-Tikhonenko A, Castaño JP, Luque RM, Eyras E. Closa A, et al. NAR Cancer. 2022 Dec 9;4(4):zcac041. doi: 10.1093/narcan/zcac041. eCollection 2022 Dec. NAR Cancer. 2022. PMID: 36518527 Free PMC article.
We further identified a gene expression signature that predicts high risk independently of the gene fusion background and includes the upregulation of the splicing factor SRRM1. Experiments in B-ALL cell lines provided further evidence for the role of SRRM1 on cell …
We further identified a gene expression signature that predicts high risk independently of the gene fusion background and includes the upreg …
A multi-scale map of cell structure fusing protein images and interactions.
Qin Y, Huttlin EL, Winsnes CF, Gosztyla ML, Wacheul L, Kelly MR, Blue SM, Zheng F, Chen M, Schaffer LV, Licon K, Bäckström A, Vaites LP, Lee JJ, Ouyang W, Liu SN, Zhang T, Silva E, Park J, Pitea A, Kreisberg JF, Gygi SP, Ma J, Harper JW, Yeo GW, Lafontaine DLJ, Lundberg E, Ideker T. Qin Y, et al. Nature. 2021 Dec;600(7889):536-542. doi: 10.1038/s41586-021-04115-9. Epub 2021 Nov 24. Nature. 2021. PMID: 34819669 Free PMC article.
The map reveals a pre-ribosomal RNA processing assembly and accessory factors, which we show govern rRNA maturation, and functional roles for SRRM1 and FAM120C in chromatin and RPS3A in splicing. By integration across scales, MuSIC increases the resolution of imaging while …
The map reveals a pre-ribosomal RNA processing assembly and accessory factors, which we show govern rRNA maturation, and functional roles fo …
Clinical value of circulating splicing factors in prostate cancer: SRRM1 as a novel predictive biomarker and therapeutic target.
Montero-Hidalgo AJ, Gómez-Gómez E, Galán-Cañete M, Porcel-Pastrana F, Pérez-Gómez JM, Ortega-Bellido M, Carrasco-Valiente J, Chamorro-Castillo L, Campos-Hernández JP, Rangel-Zuñiga OA, González-Serrano T, Sánchez-Sánchez R, Sarmento-Cabral A, Gahete MD, Jiménez-Vacas JM, Luque RM. Montero-Hidalgo AJ, et al. Mol Ther Oncol. 2024 Nov 23;32(4):200910. doi: 10.1016/j.omton.2024.200910. eCollection 2024 Dec 19. Mol Ther Oncol. 2024. PMID: 39758250 Free PMC article.
We found that plasma SRRM1 and SNRNP200 levels were elevated in PCa patients and discriminated between control individuals and PCa patients. ...Therefore, the functional and molecular effects of in vivo SRRM1 silencing were then tested in 22Rv1-derived xenograft tum …
We found that plasma SRRM1 and SNRNP200 levels were elevated in PCa patients and discriminated between control individuals and PCa pa …
Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer.
Jiménez-Vacas JM, Herrero-Aguayo V, Montero-Hidalgo AJ, Gómez-Gómez E, Fuentes-Fayos AC, León-González AJ, Sáez-Martínez P, Alors-Pérez E, Pedraza-Arévalo S, González-Serrano T, Reyes O, Martínez-López A, Sánchez-Sánchez R, Ventura S, Yubero-Serrano EM, Requena-Tapia MJ, Castaño JP, Gahete MD, Luque RM. Jiménez-Vacas JM, et al. EBioMedicine. 2020 Jan;51:102547. doi: 10.1016/j.ebiom.2019.11.008. Epub 2020 Jan 3. EBioMedicine. 2020. PMID: 31902674 Free PMC article.
Notably, overexpression of SNRNP200, SRSF3 and SRRM1 (mRNA and/or protein) were associated with relevant clinical (e.g. Gleason score, T-Stage, metastasis, biochemical recurrence, etc.) and molecular (e.g. ...INTERPRETATION: These results demonstrate that the spliceosome i …
Notably, overexpression of SNRNP200, SRSF3 and SRRM1 (mRNA and/or protein) were associated with relevant clinical (e.g. Gleason score …
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia.
Wang X, Yang C, Wei X, Zhang Y, Xiao Y, Wang J, Jiang Q, Ju Z, Gao Y, Li Y, Gao Y, Huang J. Wang X, et al. Biol Direct. 2024 Dec 26;19(1):145. doi: 10.1186/s13062-024-00579-7. Biol Direct. 2024. PMID: 39726007 Free PMC article.
Notably, our study has shown that the activity of the YY1 regulation displays distinct expression patterns in spermatogonia, specifically targeting spliceosome proteins including RBM39, HNRNPA2B1, HNRNPH3, CPSF1, PCBP1, SRRM1, and SRRM2, which play essential roles in mRNA …
Notably, our study has shown that the activity of the YY1 regulation displays distinct expression patterns in spermatogonia, specifically ta …
Single-cell transcriptome revealed dysregulated RNA-binding protein expression patterns and functions in human ankylosing spondylitis.
Ren Z, Li C, Wang J, Sui J, Ma Y. Ren Z, et al. Front Med (Lausanne). 2024 May 6;11:1369341. doi: 10.3389/fmed.2024.1369341. eCollection 2024. Front Med (Lausanne). 2024. PMID: 38770048 Free PMC article.
RESULTS: (1) Compared with the HC group, the numbers of B, DC (dendritic cells), CD14(+) Mono and CD8(+) T cells were increased in AS group, while the numbers of platelet (platelets), CD8(+) NKT, CD16(+) Mono (non-classical monocytes), Native CD4(+) T and NK were decreased. (2) T …
RESULTS: (1) Compared with the HC group, the numbers of B, DC (dendritic cells), CD14(+) Mono and CD8(+) T cells were increased in AS group, …
Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteins during mitophagy.
Baba T, Tanimura S, Yamaguchi A, Horikawa K, Yokozeki M, Hachiya S, Iemura SI, Natsume T, Matsuda N, Takeda K. Baba T, et al. Biochim Biophys Acta Mol Cell Res. 2021 Jun;1868(7):119045. doi: 10.1016/j.bbamcr.2021.119045. Epub 2021 Apr 17. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33872670 Free article.
We identified serine/arginine-related nuclear matrix protein of 160 kDa (SRm160)/SRRM1, which contains a highly phosphorylated domain rich in arginine/serine dipeptides, called the RS domain, as a nuclear protein that interacts with PGAM5. ...
We identified serine/arginine-related nuclear matrix protein of 160 kDa (SRm160)/SRRM1, which contains a highly phosphorylated domain …
A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes.
Chwalenia K, Qin F, Singh S, Li H. Chwalenia K, et al. Nucleic Acids Res. 2019 Feb 28;47(4):e24. doi: 10.1093/nar/gky1288. Nucleic Acids Res. 2019. PMID: 30590765 Free PMC article.
Using this cell-based assay, we screened 102 candidate factors involved in RNA pol II cleavage and termination, elongation, splicing, alternative splicing and R-loop formation. We discovered that two factors, SRRM1 and SF3B1, affect not only cis-SAGe chimeras, but also oth …
Using this cell-based assay, we screened 102 candidate factors involved in RNA pol II cleavage and termination, elongation, splicing, altern …
42 results