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209 results

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Page 1
STRN-ALK Fusion in Advanced Salivary Gland Carcinoma With Response to Anaplastic Lymphoma Kinase Inhibition: Case Report and Literature Review.
Kaur V, Zadeh S. Kaur V, et al. WMJ. 2024 Sep;123(4):315-319. WMJ. 2024. PMID: 39284095 Free article. Review.
We describe the case of a patient with metastatic salivary gland adenocarcinoma harboring STRN-ALK translocation, with tumor response and clinical benefit from anaplastic lymphoma kinase (ALK) inhibition. ...
We describe the case of a patient with metastatic salivary gland adenocarcinoma harboring STRN-ALK translocation, with tumor response …
STRN-ALK Fusion in Lung Adenocarcinoma with Brain Metastasis Responded Well to Ensartinib: A Case Report.
Zhang L, Xiao P, Meng F, Zhong D. Zhang L, et al. Curr Oncol. 2022 Sep 21;29(10):6749-6753. doi: 10.3390/curroncol29100530. Curr Oncol. 2022. PMID: 36290807 Free PMC article.
STRN-ALK fusion is a rare ALK rearrangement identified in non-small cell lung cancer (NSCLC) patients. Here, we reported a case of lung adenocarcinomas with brain metastasis, harboring STRN-ALK fusion, responded well to ensartinib. This case report could provide mor
STRN-ALK fusion is a rare ALK rearrangement identified in non-small cell lung cancer (NSCLC) patients. Here, we reported a case of lu
A Novel Malignant Peritoneal Mesothelioma with STRN Exon 2 and ALK Exon 20: A Case Report and Literature Review.
Miyagawa C, Takaya H, Sakai K, Nishio K, Konishi M, Minamiguchi S, Shimada T, Matsumura N. Miyagawa C, et al. Oncologist. 2021 May;26(5):356-361. doi: 10.1002/onco.13714. Epub 2021 Feb 22. Oncologist. 2021. PMID: 33555117 Free PMC article. Review.
This is the fourth reported case of MPM with STRN-ALK fusion. Of the 45 cancer cases with STRN-ALK fusion in which the fusion partners were examined, all cases except for the current case showed fusion of exon 3 of STRN and exon 20 of ALK. This is the first c …
This is the fourth reported case of MPM with STRN-ALK fusion. Of the 45 cancer cases with STRN-ALK fusion in which the fusion …
The thalamic reticular nucleus orchestrates social memory.
Wang F, Sun H, Chen M, Feng B, Lu Y, Lyu M, Cui D, Zhai Y, Zhang Y, Zhu Y, Wang C, Wu H, Ma X, Zhu F, Wang Q, Li Y. Wang F, et al. Neuron. 2024 Jul 17;112(14):2368-2385.e11. doi: 10.1016/j.neuron.2024.04.013. Epub 2024 May 2. Neuron. 2024. PMID: 38701789 Free article.
Here, we demonstrated that parvalbumin-positive neurons in the sensory thalamic reticular nucleus (sTRN(Pvalb)) are necessary and sufficient for mice to memorize conspecifics. sTRN(Pvalb) neurons receiving glutamatergic projections from the posterior parietal cortex …
Here, we demonstrated that parvalbumin-positive neurons in the sensory thalamic reticular nucleus (sTRN(Pvalb)) are necessary and suf …
Inhibition of ALK-Signaling Overcomes STRN-ALK-Induced Downregulation of the Sodium Iodine Symporter and Restores Radioiodine Uptake in Thyroid Cells.
Nikitski AV, Condello V, Divakaran SS, Nikiforov YE. Nikitski AV, et al. Thyroid. 2023 Apr;33(4):464-473. doi: 10.1089/thy.2022.0533. Epub 2023 Feb 27. Thyroid. 2023. PMID: 36585857 Free PMC article.
Methods: The expression of NIS at different stages of ALK-driven carcinogenesis was analyzed using a mouse model of STRN-ALK-driven thyroid cancer. For in vitro experiments, a system of doxycycline-inducible expression of STRN-ALK was generated using PCCL3 normal th …
Methods: The expression of NIS at different stages of ALK-driven carcinogenesis was analyzed using a mouse model of STRN-ALK-driven t …
High STRN Expression Promotes HCC Invasion and Migration but Not Cell Proliferation or Apoptosis through Facilitating Epithelial-Mesenchymal Transition.
Du QY, Yao JH, Zhou YC, Xu LJ, Zhao FY, Yang Y. Du QY, et al. Biomed Res Int. 2020 Mar 23;2020:6152925. doi: 10.1155/2020/6152925. eCollection 2020. Biomed Res Int. 2020. PMID: 32280692 Free PMC article.
A STRN-ALK fusion protein has been recently identified as a potential therapeutic target in multiple cancers; however, the role of STRN alone in regulating the biological function of hepatocellular carcinoma (HCC) remains unclear. ...In vitro, high expression of …
A STRN-ALK fusion protein has been recently identified as a potential therapeutic target in multiple cancers; however, the role of …
The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic pain.
Wang XY, Xu X, Chen R, Jia WB, Xu PF, Liu XQ, Zhang Y, Liu XF, Zhang Y. Wang XY, et al. Cell Rep. 2023 Oct 31;42(10):113170. doi: 10.1016/j.celrep.2023.113170. Epub 2023 Sep 21. Cell Rep. 2023. PMID: 37738124 Free article.
Here, we dissect an inhibitory projection from the sensory thalamic reticular nucleus (sTRN) to the LHb, which is activated by acute aversive stimuli. However, chronic restraint stress (CRS) weakens sTRN-LHb synaptic strength, and this synaptic attenuation is indisp …
Here, we dissect an inhibitory projection from the sensory thalamic reticular nucleus (sTRN) to the LHb, which is activated by acute …
STRN-ALK, A Novel In-Frame Fusion With Response to Alectinib.
Nagasaka M, Sarvadevabatla N, Iwata S, Ge Y, Sukari A, Klosowski C, Yanagihara R. Nagasaka M, et al. JTO Clin Res Rep. 2020 Nov 25;2(2):100125. doi: 10.1016/j.jtocrr.2020.100125. eCollection 2021 Feb. JTO Clin Res Rep. 2020. PMID: 34589985 Free PMC article. No abstract available.
STRN-ALK rearranged malignant peritoneal mesothelioma-Presenting with bilateral extensive pelvic masses in a young woman: Mimicking low-grade serous ovarian carcinoma.
Bulutay P, Vatansever D, Taskiran C, Mericoz CA, Tokat F, Kapucuoglu N, Kulac I. Bulutay P, et al. Indian J Pathol Microbiol. 2023 Apr-Jun;66(2):392-395. doi: 10.4103/ijpm.ijpm_360_21. Indian J Pathol Microbiol. 2023. PMID: 37077094 Free article.
Here, we report a case of 18-year-old women with STRN-ALK-rearranged MPM and no previous exposure to asbestos. This case was presented with bilateral pelvic masses and histologically was displaying pure papillary morphology with mild-to-moderate nuclear atypia, psammoma bo …
Here, we report a case of 18-year-old women with STRN-ALK-rearranged MPM and no previous exposure to asbestos. This case was presente …
Ciliated Muconodular Papillary Tumors of the Lung Harboring STRN::ALK Fusion: Case Report and Review of the Literature.
Zhang X, Yuan W, Luo R, Luan L, Huang J, Lu S, Sujie A, Hou Y. Zhang X, et al. Int J Surg Pathol. 2024 Oct;32(7):1357-1363. doi: 10.1177/10668969241226707. Epub 2024 Feb 6. Int J Surg Pathol. 2024. PMID: 38321754 Review.
Microscopic analysis revealed tumors with glandular or papillary structures, consisting of mucinous cells, ciliated columnar cells, and basal cells. Notably, both patients exhibited STRN::ALK fusion, a finding not previously associated with CMPT. STRN::ALK fusion se …
Microscopic analysis revealed tumors with glandular or papillary structures, consisting of mucinous cells, ciliated columnar cells, and basa …
209 results