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1998 2
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2011 3
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105 results

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Page 1
A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms.
Arias-Vásquez A, Groffen AJ, Spijker S, Ouwens KG, Klein M, Vojinovic D, Galesloot TE, Bralten J, Hottenga JJ, van der Most PJ, Kattenberg VM, Pool R, Nolte IM, Penninx BWJH, Fedko IO, Dolan CV, Nivard MG, den Braber A, van Duijn CM, Hoekstra PJ, Buitelaar JK, Kiemeney LA, Hoogman M, Middeldorp CM, Draisma HHM, Vermeulen SH, Sánchez-Mora C, Ramos-Quiroga JA, Ribasés M; EAGLE-ADHD Consortium; Hartman CA, Kooij JJS, Amin N, Smit AB, Franke B, Boomsma DI. Arias-Vásquez A, et al. Behav Genet. 2019 May;49(3):270-285. doi: 10.1007/s10519-018-09947-2. Epub 2019 Jan 18. Behav Genet. 2019. PMID: 30659475
Genome-wide meta-analysis of the SAGA and EAGLE data (n = 29,465) increased the strength of the association with the SNP rs12661753. In human HEK293 cells, expression of STXBP5-AS1 enhanced the expression of a reporter construct of STXBP5, a gene known to be involve …
Genome-wide meta-analysis of the SAGA and EAGLE data (n = 29,465) increased the strength of the association with the SNP rs12661753. In huma …
The syntaxin-binding protein STXBP5 regulates progerin expression.
Qi H, Wu Y, Zhang W, Yu N, Lu X, Liu J. Qi H, et al. Sci Rep. 2024 Oct 8;14(1):23376. doi: 10.1038/s41598-024-74621-z. Sci Rep. 2024. PMID: 39379476 Free PMC article.
In this study, through public dataset analysis, we identified Syntaxin Binding Protein 5 (STXBP5) as an influencing factor of progerin expression. STXBP5 overexpression accelerated the onset of senescence, while STXBP5 deletion suppressed progerin expression, …
In this study, through public dataset analysis, we identified Syntaxin Binding Protein 5 (STXBP5) as an influencing factor of progeri …
LncRNA STXBP5-AS1 suppressed cervical cancer progression via targeting miR-96-5p/PTEN axis.
Shao S, Wang C, Wang S, Zhang H, Zhang Y. Shao S, et al. Biomed Pharmacother. 2019 Sep;117:109082. doi: 10.1016/j.biopha.2019.109082. Epub 2019 Jun 15. Biomed Pharmacother. 2019. PMID: 31212131 Free article.
However, the effects and underlying mechanisms of STXBP5-AS1 in CC are still unknown. The expression of STXBP5-AS1, miR-96-5p, and PTEN in CC was explored by qRT-PCR. CCK-8 and transwell assays were used to determine the roles of STXBP5-AS1 on CC progression. …
However, the effects and underlying mechanisms of STXBP5-AS1 in CC are still unknown. The expression of STXBP5-AS1, miR-96-5p, …
LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression.
Chen S, Huang L, Li G, Qiu F, Wang Y, Yang C, Pan J, Wu Z, Chen J, Tian Y. Chen S, et al. Clin Epigenetics. 2020 Nov 7;12(1):168. doi: 10.1186/s13148-020-00961-y. Clin Epigenetics. 2020. PMID: 33160411 Free PMC article.
The methylation was quantified by bisulfite sequencing. We showed downregulation of STXBP5-AS1 in PC associated with poor prognosis. Ectopic STXBP5-AS1 inhibited chemoresistance and metastasis of PC cells. In addition, STXBP5-AS1 compromised stemness of PC ce …
The methylation was quantified by bisulfite sequencing. We showed downregulation of STXBP5-AS1 in PC associated with poor prognosis. …
Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.
Zhu Q, Yamakuchi M, Ture S, de la Luz Garcia-Hernandez M, Ko KA, Modjeski KL, LoMonaco MB, Johnson AD, O'Donnell CJ, Takai Y, Morrell CN, Lowenstein CJ. Zhu Q, et al. J Clin Invest. 2014 Oct;124(10):4503-16. doi: 10.1172/JCI71245. Epub 2014 Sep 17. J Clin Invest. 2014. PMID: 25244095 Free PMC article.
We hypothesized that STXBP5 inhibits endothelial cell exocytosis. We found that STXBP5 is expressed in human endothelial cells and colocalizes with and interacts with syntaxin 4. ...Furthermore, platelets from Stxbp5 KO mice had defects in platelet secretion …
We hypothesized that STXBP5 inhibits endothelial cell exocytosis. We found that STXBP5 is expressed in human endothelial cells …
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.
Huang J, Huffman JE, Yamakuchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, Böhm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Ikram MA; Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working Group; Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP; CARDIoGRAM Consortium; Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Spector TD, Meigs JB, Marz W, Eriksson P, Becker LC, Morange PE, Soranzo N, Williams SM, Hayward C, van der Harst P, Hamsten A, Lowenstein CJ, Strachan DP, O'Donnell CJ; CHARGE Consortium H… See abstract for full author list ➔ Huang J, et al. Arterioscler Thromb Vasc Biol. 2014 May;34(5):1093-101. doi: 10.1161/ATVBAHA.113.302088. Epub 2014 Feb 27. Arterioscler Thromb Vasc Biol. 2014. PMID: 24578379 Free PMC article.
We further found evidence for the association of lead SNPs in STXBP5 and STX2 with expression levels of the respective transcripts. In in vitro cell studies, silencing STXBP5 decreased the release of tPA from vascular endothelial cells, whereas silencing STX2 increa …
We further found evidence for the association of lead SNPs in STXBP5 and STX2 with expression levels of the respective transcripts. I …
Long noncoding RNA STXBP5-AS1 inhibits cell proliferation, migration, and invasion through inhibiting the PI3K/AKT signaling pathway in gastric cancer cells.
Cen D, Huang H, Yang L, Guo K, Zhang J. Cen D, et al. Onco Targets Ther. 2019 Mar 8;12:1929-1936. doi: 10.2147/OTT.S194463. eCollection 2019. Onco Targets Ther. 2019. PMID: 30881044 Free PMC article.
Real-time polymerase chain reaction (qPCR) and Western blot assays were performed to investigate the relationship between STXBP5-AS1 and STXBP5. Finally, the correlation between STXBP5-AS1 and phosphorylated AKT1 (p-AKT1) was explored to reveal the potential …
Real-time polymerase chain reaction (qPCR) and Western blot assays were performed to investigate the relationship between STXBP5-AS1 …
Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.
Ye S, Huang Y, Joshi S, Zhang J, Yang F, Zhang G, Smyth SS, Li Z, Takai Y, Whiteheart SW. Ye S, et al. J Clin Invest. 2014 Oct;124(10):4517-28. doi: 10.1172/JCI75572. Epub 2014 Sep 17. J Clin Invest. 2014. PMID: 25244094 Free PMC article.
Coimmunoprecipitation studies showed that STXBP5 interacts with core secretion machinery complexes, such as syntaxin-11/SNAP23 heterodimers, and fractionation studies suggested that STXBP5 also interacts with the platelet cytoskeleton. ...Transplantation experiments …
Coimmunoprecipitation studies showed that STXBP5 interacts with core secretion machinery complexes, such as syntaxin-11/SNAP23 hetero …
Aberrant hypermethylation induced downregulation of antisense lncRNA STXBP5-AS1 and its sense gene STXBP5 correlate with tumorigenesis of glioma.
Wang J, Yang L, Li Y, Wang XB, Yang W, Liu F, Wu XB. Wang J, et al. Life Sci. 2021 Aug 1;278:119590. doi: 10.1016/j.lfs.2021.119590. Epub 2021 May 6. Life Sci. 2021. PMID: 33965377
We found that promoter methylation frequency was significantly higher in glioma tissues. Functionally, overexpression of STXBP5 and STXBP5-AS1 inhibited cell proliferation, migration, and invasion and promoted apoptosis in vitro, whereas depletion of STXBP5 a …
We found that promoter methylation frequency was significantly higher in glioma tissues. Functionally, overexpression of STXBP5 and …
Ginsenoside Rh2 upregulates long noncoding RNA STXBP5-AS1 to sponge microRNA-4425 in suppressing breast cancer cell proliferation.
Park JE, Kim HW, Yun SH, Kim SJ. Park JE, et al. J Ginseng Res. 2021 Nov;45(6):754-762. doi: 10.1016/j.jgr.2021.08.006. Epub 2021 Aug 27. J Ginseng Res. 2021. PMID: 34764730 Free PMC article.
The ceRNA relationship between STXBP5-AS1 and miR-4425 was examined by measuring the luciferase activity of a recombinant luciferase/STXBP5-AS1 plasmid construct in the presence of mimic miR-4425. ...MiR-4425 was identified to have a binding site on STXBP5-AS …
The ceRNA relationship between STXBP5-AS1 and miR-4425 was examined by measuring the luciferase activity of a recombinant luciferase/ …
105 results