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235 results

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Page 1
FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development.
Ji J, Shen J, Xu Y, Xie M, Qian Q, Qiu T, Shi W, Ren D, Ma J, Liu W, Liu B. Ji J, et al. Cell Death Dis. 2022 May 7;13(5):442. doi: 10.1038/s41419-022-04892-9. Cell Death Dis. 2022. PMID: 35525855 Free PMC article.
SAD1/UNC84 domain protein-2 (SUN2) plays a tumor suppressor role in various types of cancer by inhibiting cancer cell proliferation, migration and promoting apoptosis. However, the post-translational regulation of SUN2 and the cellular mechanism responsible for its …
SAD1/UNC84 domain protein-2 (SUN2) plays a tumor suppressor role in various types of cancer by inhibiting cancer cell proliferation, …
SUN2: A potential therapeutic target in cancer.
Chen X, Chen Y, Huang HM, Li HD, Bu FT, Pan XY, Yang Y, Li WX, Li XF, Huang C, Meng XM, Li J. Chen X, et al. Oncol Lett. 2019 Feb;17(2):1401-1408. doi: 10.3892/ol.2018.9764. Epub 2018 Nov 27. Oncol Lett. 2019. PMID: 30675193 Free PMC article. Review.
Furthermore, SUN2 inhibits cancer cell proliferation, migration and promotes apoptosis. Recent reports have also shown that SUN2 serves prominent roles in resistance to the excessive DNA damage that destabilizes the genome and promotes cancer development, and these …
Furthermore, SUN2 inhibits cancer cell proliferation, migration and promotes apoptosis. Recent reports have also shown that SUN2 …
Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1.
Huang Y, Peng Q, Tian X, Chen C, Zhu X, Huang C, Huo Z, Liu Y, Yang C, Liu C, Zhang P. Huang Y, et al. Nat Commun. 2024 Jan 5;15(1):296. doi: 10.1038/s41467-023-44580-6. Nat Commun. 2024. PMID: 38177122 Free PMC article.
In contrast, SUN2 does not affect the infection of non-flaviviridae RNA viruses. All three regions of SUN2 are required for its proviral effect. ...SUN2 is required for the interaction between cytoskeleton actin and ZIKV nonstructural protein 1 (NS1). ...
In contrast, SUN2 does not affect the infection of non-flaviviridae RNA viruses. All three regions of SUN2 are required for it …
SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II.
Ulferts S, Grosse R. Ulferts S, et al. EMBO Rep. 2024 Nov;25(11):4728-4748. doi: 10.1038/s44319-024-00274-8. Epub 2024 Sep 24. EMBO Rep. 2024. PMID: 39317734 Free PMC article.
Here we found that calcium elevations trigger rapid nuclear actin assembly requiring the nuclear membrane protein SUN2 independently of its function as a component of the LINC complex. Instead, SUN2 colocalized and associated with the formin and actin nucleator INF2 …
Here we found that calcium elevations trigger rapid nuclear actin assembly requiring the nuclear membrane protein SUN2 independently …
Emery-Dreifuss muscular dystrophy.
Heller SA, Shih R, Kalra R, Kang PB. Heller SA, et al. Muscle Nerve. 2020 Apr;61(4):436-448. doi: 10.1002/mus.26782. Epub 2019 Dec 28. Muscle Nerve. 2020. PMID: 31840275 Free PMC article. Review.
Associated genes include EMD, LMNA, SYNE1, SYNE2, FHL1, TMEM43, SUN1, SUN2, and TTN, encoding emerin, lamin A/C, nesprin-1, nesprin-2, FHL1, LUMA, SUN1, SUN2, and titin, respectively. ...
Associated genes include EMD, LMNA, SYNE1, SYNE2, FHL1, TMEM43, SUN1, SUN2, and TTN, encoding emerin, lamin A/C, nesprin-1, nesprin-2 …
SUN2 Modulates the Propagation of HSV-1.
Cruz-Palomar K, Hawkins J, Vandal C, Quenneville J, Gagnon É, Lippé R. Cruz-Palomar K, et al. J Virol. 2022 May 11;96(9):e0045322. doi: 10.1128/jvi.00453-22. Epub 2022 Apr 18. J Virol. 2022. PMID: 35435724 Free PMC article.
This SUN2 dependency may be linked to its greater impact on perinuclear spacing in infected cells compared to SUN1. ...Using dominant negative constructs and RNA interference (RNAi), the data reveal that SUN2 exhibits antiviral propriety toward HSV-1, as disrupting …
This SUN2 dependency may be linked to its greater impact on perinuclear spacing in infected cells compared to SUN1. ...Using dominant …
Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite.
Li Y, Huang M, Wang M, Wang Y, Deng P, Li C, Huang J, Chen H, Wei Z, Ouyang Q, Zhao J, Lu Y, Su S. Li Y, et al. Cancer Cell. 2024 Jun 10;42(6):985-1002.e18. doi: 10.1016/j.ccell.2024.05.006. Epub 2024 May 30. Cancer Cell. 2024. PMID: 38821061 Free article.
NAA disrupts the formation of immunological synapse by promoting PCAF-induced acetylation of lamin A-K542, which inhibits the integration between lamin A and SUN2 and impairs polarization of lytic granules. We uncover that tumor cells mimic the anti-inflammatory mechanism …
NAA disrupts the formation of immunological synapse by promoting PCAF-induced acetylation of lamin A-K542, which inhibits the integration be …
SUN2 regulates mitotic duration in response to extracellular matrix rigidity.
Belaadi N, Pernet L, Aureille J, Chadeuf G, Rio M, Vaillant N, Vitiello E, Lafanechère L, Loirand G, Guilluy C. Belaadi N, et al. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2116167119. doi: 10.1073/pnas.2116167119. Epub 2022 Nov 2. Proc Natl Acad Sci U S A. 2022. PMID: 36322767 Free PMC article.
We noticed that ECM elasticity up-regulates the expression of the linker of nucleoskeleton and cytoskeleton (LINC) complex component SUN2, which in turn promotes metaphase-to-anaphase transition by acting on mitotic spindle formation, whereas when cells adhere to soft ECM, …
We noticed that ECM elasticity up-regulates the expression of the linker of nucleoskeleton and cytoskeleton (LINC) complex component SUN2 …
Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence.
Yue X, Cui J, Sun Z, Liu L, Li Y, Shao L, Feng Q, Wang Z, Hambright WS, Cui Y, Huard J, Mu Y, Mu X. Yue X, et al. Cell Death Discov. 2023 May 17;9(1):167. doi: 10.1038/s41420-023-01467-1. Cell Death Discov. 2023. PMID: 37198162 Free PMC article.
Our recent study of Hutchinson-Gilford progeria syndrome (HGPS) disease revealed the role of nuclear membrane protein Sun2 in mediating nuclear damages and cellular senescence in progeria cells. However, the potential role of Sun2 in mechanical stress-induced nuclea …
Our recent study of Hutchinson-Gilford progeria syndrome (HGPS) disease revealed the role of nuclear membrane protein Sun2 in mediati …
SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV.
Donahue DA, Amraoui S, di Nunzio F, Kieffer C, Porrot F, Opp S, Diaz-Griffero F, Casartelli N, Schwartz O. Donahue DA, et al. J Virol. 2016 Mar 28;90(8):4199-4214. doi: 10.1128/JVI.03202-15. Print 2016 Apr. J Virol. 2016. PMID: 26865710 Free PMC article.
In a previous screen of putative interferon-stimulated genes, SUN2 was shown to inhibit HIV-1 infection in an uncharacterized manner. SUN2 is an inner nuclear membrane protein belonging to the linker of nucleoskeleton and cytoskeleton complex. We have analyzed here …
In a previous screen of putative interferon-stimulated genes, SUN2 was shown to inhibit HIV-1 infection in an uncharacterized manner. …
235 results