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Page 1
Somatic Variants in SVIL in Cerebral Aneurysms.
Lai PMR, Ryu JY, Park SC, Gross BA, Dickinson LD, Dagen S, Aziz-Sultan MA, Boulos AS, Barrow DL, Batjer HH, Blackburn S, Chang EF, Chen PR, Colby GP, Cosgrove GR, David CA, Day AL, Frerichs KU, Niemela M, Ojemann SG, Patel NJ, Shi X, Valle-Giler EP, Wang AC, Welch BG, Zusman EE, Weiss ST, Du R. Lai PMR, et al. Neurol Genet. 2022 Nov 28;8(6):e200040. doi: 10.1212/NXG.0000000000200040. eCollection 2022 Dec. Neurol Genet. 2022. PMID: 36475054 Free PMC article.
RESULTS: Somatic variants involved in supervillin (SVIL) or its regulation were found in 17% of aneurysm tissues. In the presence of a mutation in the SVIL gene, the expression level of SVIL was downregulated in the aneurysm tissue compared with normal contro …
RESULTS: Somatic variants involved in supervillin (SVIL) or its regulation were found in 17% of aneurysm tissues. In the presence of …
Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration.
Nie Z, Guo N, Peng Y, Gao Y, Cao H, Zhang S. Nie Z, et al. Sci Rep. 2023 Sep 5;13(1):14595. doi: 10.1038/s41598-023-41759-1. Sci Rep. 2023. PMID: 37670039 Free PMC article.
SVIL is a member of the villin/gelsolin superfamily and is responsible for encoding supervillin. ...Our work determined that the expression of SVIL in bladder cancer tissue was significantly lower than that in normal tissue. However, in bladder cancer tissues, the h …
SVIL is a member of the villin/gelsolin superfamily and is responsible for encoding supervillin. ...Our work determined that the expr …
Deep learning enables genetic analysis of the human thoracic aorta.
Pirruccello JP, Chaffin MD, Chou EL, Fleming SJ, Lin H, Nekoui M, Khurshid S, Friedman SF, Bick AG, Arduini A, Weng LC, Choi SH, Akkad AD, Batra P, Tucker NR, Hall AW, Roselli C, Benjamin EJ, Vellarikkal SK, Gupta RM, Stegmann CM, Juric D, Stone JR, Vasan RS, Ho JE, Hoffmann U, Lubitz SA, Philippakis AA, Lindsay ME, Ellinor PT. Pirruccello JP, et al. Nat Genet. 2022 Jan;54(1):40-51. doi: 10.1038/s41588-021-00962-4. Epub 2021 Nov 26. Nat Genet. 2022. PMID: 34837083 Free PMC article.
Transcriptome-wide analyses, rare-variant burden tests and human aortic single nucleus RNA sequencing prioritized genes including SVIL, which was strongly associated with descending aortic diameter. A polygenic score for ascending aortic diameter was associated with thorac …
Transcriptome-wide analyses, rare-variant burden tests and human aortic single nucleus RNA sequencing prioritized genes including SVIL …
SVIL promotes ovarian cancer progression and epithelial-mesenchymal transition under hypoxic conditions through the TGF-beta/Smad pathway.
Dai D, Li C, Xia H, Qi C, Lyu M, Yao Z, Zhang F, Zhu Y, Qi M, Cao X. Dai D, et al. Gynecol Oncol. 2024 Nov;190:167-178. doi: 10.1016/j.ygyno.2024.07.688. Epub 2024 Aug 28. Gynecol Oncol. 2024. PMID: 39197416
Further, we investigated the relevant pathways of SVIL and confirmed the effects of SVIL on ovarian cancer progression by using nude mouse in situ tumor models. ...Our study demonstrated that SVIL may be a novel target for the treatment of ovarian cancer....
Further, we investigated the relevant pathways of SVIL and confirmed the effects of SVIL on ovarian cancer progression by usin …
N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1.
Hu Z, Zhu L, Zhang Y, Chen B. Hu Z, et al. Bioengineered. 2022 Feb;13(2):3093-3107. doi: 10.1080/21655979.2022.2025697. Bioengineered. 2022. PMID: 35068325 Free PMC article.
Mechanistically, METTL3 increased the m6A modification and transcript stability of SVIL-AS1. The enhanced SVIL-AS1 expression mediated by METTL3 suppressed E2F1 and E2F1-target genes. Moreover, SVIL-AS1 accelerated E2F1 degradation. The reduction in cell prol …
Mechanistically, METTL3 increased the m6A modification and transcript stability of SVIL-AS1. The enhanced SVIL-AS1 expression …
Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.
Tadros R, Zheng SL, Grace C, Jordà P, Francis C, Jurgens SJ, Thomson KL, Harper AR, Ormondroyd E, West DM, Xu X, Theotokis PI, Buchan RJ, McGurk KA, Mazzarotto F, Boschi B, Pelo E, Lee M, Noseda M, Varnava A, Vermeer AM, Walsh R, Amin AS, van Slegtenhorst MA, Roslin N, Strug LJ, Salvi E, Lanzani C, de Marvao A; Hypergenes InterOmics Collaborators; Roberts JD, Tremblay-Gravel M, Giraldeau G, Cadrin-Tourigny J, L'Allier PL, Garceau P, Talajic M, Pinto YM, Rakowski H, Pantazis A, Baksi J, Halliday BP, Prasad SK, Barton PJ, O'Regan DP, Cook SA, de Boer RA, Christiaans I, Michels M, Kramer CM, Ho CY, Neubauer S; HCMR Investigators; Matthews PM, Wilde AA, Tardif JC, Olivotto I, Adler A, Goel A, Ware JS, Bezzina CR, Watkins H. Tadros R, et al. medRxiv [Preprint]. 2023 Feb 6:2023.01.28.23285147. doi: 10.1101/2023.01.28.23285147. medRxiv. 2023. PMID: 36778260 Free PMC article. Preprint.
Amongst the common variant HCM loci, we identify a novel HCM disease gene, SVIL, which encodes the actin-binding protein supervillin, showing that rare truncating SVIL variants cause HCM. ...
Amongst the common variant HCM loci, we identify a novel HCM disease gene, SVIL, which encodes the actin-binding protein supervillin, …
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.
Kuang C, Xia M, An G, Liu C, Hu C, Zhang J, Liu Z, Meng B, Su P, Xia J, Guo J, Zhu Y, Liu X, Wu X, Shen Y, Feng X, He Y, Li J, Qiu L, Zhou J, Zhou W. Kuang C, et al. Nat Commun. 2023 Apr 13;14(1):2093. doi: 10.1038/s41467-023-37699-z. Nat Commun. 2023. PMID: 37055385 Free PMC article.
Extrinsic serine is transported into MKs through SLC38A1 and downregulates SVIL via SAM-mediated tri-methylation of H3K9, ultimately leading to the impairment of megakaryopoiesis. ...
Extrinsic serine is transported into MKs through SLC38A1 and downregulates SVIL via SAM-mediated tri-methylation of H3K9, ultimately …
Identification of a competing endogenous RNA axis "SVIL-AS1/miR-103a/ICE1" associated with chemoresistance in lung adenocarcinoma by comprehensive bioinformatics analysis.
Guo L, Ding L, Tang J. Guo L, et al. Cancer Med. 2021 Sep;10(17):6022-6034. doi: 10.1002/cam4.4132. Epub 2021 Jul 15. Cancer Med. 2021. PMID: 34264003 Free PMC article.
RESULTS: Midnightblue module was the only WGCNA module positively correlated with chemosensitivity, in which the function of genes was related to cancer progression. SVIL-AS1/miR-103a/ICE1 was constructed based on midnightblue module. High expression of SVIl-AS1 and …
RESULTS: Midnightblue module was the only WGCNA module positively correlated with chemosensitivity, in which the function of genes was relat …
Engineered exosomes transporting the lncRNA, SVIL-AS1, inhibit the progression of lung cancer via targeting miR-21-5p.
Xu H, Ma H, Zha L, Li Q, Pan H, Zhang L. Xu H, et al. Am J Cancer Res. 2024 Jul 15;14(7):3335-3347. doi: 10.62347/YRJK5888. eCollection 2024. Am J Cancer Res. 2024. PMID: 39113865 Free PMC article.
In this study, we constructed engineered exosomes carrying the long non-coding RNA (lncRNA) SVIL-AS1 (SVIL-AS1 Exos), and explored its role and mechanism in lung cancer. After the construction of SVIL-AS1 Exos, their physicochemical characteristics were ident …
In this study, we constructed engineered exosomes carrying the long non-coding RNA (lncRNA) SVIL-AS1 (SVIL-AS1 Exos), and expl …
The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing.
Hasegawa H, Hyodo T, Asano E, Ito S, Maeda M, Kuribayashi H, Natsume A, Wakabayashi T, Hamaguchi M, Senga T. Hasegawa H, et al. J Cell Sci. 2013 Aug 15;126(Pt 16):3627-37. doi: 10.1242/jcs.124818. Epub 2013 Jun 7. J Cell Sci. 2013. PMID: 23750008
In this report, we show that an actin/myosin-II-binding protein, supervillin (SVIL), is a substrate of PLK1. PLK1 phosphorylates Ser238 of SVIL, which can promote the localization of SVIL to the central spindle and association with PRC1. ...SVIL has bo …
In this report, we show that an actin/myosin-II-binding protein, supervillin (SVIL), is a substrate of PLK1. PLK1 phosphorylates Ser2 …
90 results