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Year Number of Results
2001 3
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46 results

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Page 1
SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.
Li Z, Tao Y, Gao Z, Peng S, Lai Y, Li K, Chen X, Huang H. Li Z, et al. J Transl Med. 2023 May 5;21(1):303. doi: 10.1186/s12967-023-04146-y. J Transl Med. 2023. PMID: 37147713 Free PMC article.
We performed coimmunoprecipitation and protein stability assays to clarify the mechanism of SYTL2. RESULTS: We discovered a pseudopodia regulator, SYTL2, which correlated with a higher Gleason score, worse prognosis and higher risk of metastasis. ...Targeting FSCN1 …
We performed coimmunoprecipitation and protein stability assays to clarify the mechanism of SYTL2. RESULTS: We discovered a pseudopod …
Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm.
Xie X, Yuan Y, Huang Y, Hong X, Hong S, Chen G, Chen Y, Lin Y, Lu W, Fu W, Wang L. Xie X, et al. Chin Med J (Engl). 2024 May 5;137(9):1105-1114. doi: 10.1097/CM9.0000000000002808. Epub 2023 Aug 28. Chin Med J (Engl). 2024. PMID: 37640670 Free PMC article.
Additionally, COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall tissue. ...CONCLUSIONS: COL1A1 and SYTL2 may serve as diagnostic marker genes for TAA. The upregulation of SYTL2 and COL1A1 may be involved in …
Additionally, COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall tissue. ...CONCL …
Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer.
Sung HY, Han J, Ju W, Ahn JH. Sung HY, et al. Oncol Rep. 2016 Jul;36(1):535-41. doi: 10.3892/or.2016.4835. Epub 2016 May 24. Oncol Rep. 2016. PMID: 27220283
The mRNA expression of SYTL2 was significantly upregulated and the methylation of specific CpG sites within the SYTL2 promoter was decreased in the metastatic implants from the ovarian carcinoma xenografts compared to wild-type SK-OV-3 cells. Treatment with the deme …
The mRNA expression of SYTL2 was significantly upregulated and the methylation of specific CpG sites within the SYTL2 promoter …
Lineage tracing of T cell differentiation from T-iPSC by 2D feeder-free culture and 3D organoid culture.
Ishiguro Y, Iriguchi S, Asano S, Shinohara T, Shiina S, Arima S, Kassai Y, Sakai Y, Obama K, Kaneko S. Ishiguro Y, et al. Front Immunol. 2023 Dec 15;14:1303713. doi: 10.3389/fimmu.2023.1303713. eCollection 2023. Front Immunol. 2023. PMID: 38162650 Free PMC article.
RESULTS: The scRNA-seq data indicated that T-iPS-T cells are similar to T cells transitioning to human thymocytes, with SELENOW, GIMAP4, 7, SATB1, SALMF1, IL7R, SYTL2, S100A11, STAT1, IFITM1, LZTFL1 and SOX4 identified as candidate genes for the 2D feeder-free induction of …
RESULTS: The scRNA-seq data indicated that T-iPS-T cells are similar to T cells transitioning to human thymocytes, with SELENOW, GIMAP4, 7, …
Long noncoding RNA BSN-AS2 induced by E2F1 promotes spinal osteosarcoma progression by targeting miR-654-3p/SYTL2 axis.
Zhou X, Li J, Teng J, Liu Y, Zhang D, Liu L, Zhang W. Zhou X, et al. Cancer Cell Int. 2020 Apr 25;20:133. doi: 10.1186/s12935-020-01205-y. eCollection 2020. Cancer Cell Int. 2020. PMID: 32351327 Free PMC article.
After that, the binding effect of between miR-654-3p and SYTL2 was proved. Finally, rescue experiments illustrated that miR-654-3p inhibition or SYTL2 overexpression could counteract the inhibitory effect caused by BSN-AS2 deficiency on spinal OS progression. In con …
After that, the binding effect of between miR-654-3p and SYTL2 was proved. Finally, rescue experiments illustrated that miR-654-3p in …
Identification of Potential Diagnostic Biomarkers From Circulating Cells During the Course of Sleep Deprivation-Related Myocardial Infarction Based on Bioinformatics Analyses.
Chen X, Li Q, Zhang Z, Yang M, Wang E. Chen X, et al. Front Cardiovasc Med. 2022 Mar 17;9:843426. doi: 10.3389/fcvm.2022.843426. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35369343 Free PMC article.
Next, we found that resting NK cells were downregulated in both the MI samples and SD samples, which is similar to the changes noted for SYTL2. Importantly, SYTL2 was strongly positively correlated not only with resting NK cells but also with most genes related to N …
Next, we found that resting NK cells were downregulated in both the MI samples and SD samples, which is similar to the changes noted for …
[Alveolar Soft Part Sarcoma-The Angiogenic Mechanism Regulated by a Fusion Gene Product].
Nakamura T, Tanaka M. Nakamura T, et al. Gan To Kagaku Ryoho. 2024 Jun;51(6):585-590. Gan To Kagaku Ryoho. 2024. PMID: 39009511 Japanese.
Angiogenesis-associated enhancers and important target genes, Rab27a, Sytl2, Pdgfb and Vwf were identified by epigenetic CRISPR screening. Rab27a and Sytl2 facilitates trafficking of cytoplasmic vesicles containing angiogenic factors such as Pdgfb and Vwf, resulting …
Angiogenesis-associated enhancers and important target genes, Rab27a, Sytl2, Pdgfb and Vwf were identified by epigenetic CRISPR scree …
ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma.
Tanaka M, Chuaychob S, Homme M, Yamazaki Y, Lyu R, Yamashita K, Ae K, Matsumoto S, Kumegawa K, Maruyama R, Qu W, Miyagi Y, Yokokawa R, Nakamura T. Tanaka M, et al. Nat Commun. 2023 Apr 7;14(1):1957. doi: 10.1038/s41467-023-37049-z. Nat Commun. 2023. PMID: 37029109 Free PMC article.
Using epigenomic CRISPR/dCas9 screening, we identify Pdgfb, Rab27a, Sytl2, and Vwf as critical targets associated with reduced enhancer activities due to the ASPSCR1::TFE3 loss. Upregulation of Rab27a and Sytl2 promotes angiogenic factor-trafficking to facilitate AS …
Using epigenomic CRISPR/dCas9 screening, we identify Pdgfb, Rab27a, Sytl2, and Vwf as critical targets associated with reduced enhanc …
Comprehensive profiling of 1015 patients' exomes reveals genomic-clinical associations in colorectal cancer.
Zhao Q, Wang F, Chen YX, Chen S, Yao YC, Zeng ZL, Jiang TJ, Wang YN, Wu CY, Jing Y, Huang YS, Zhang J, Wang ZX, He MM, Pu HY, Mai ZJ, Wu QN, Long R, Zhang X, Huang T, Xu M, Qiu MZ, Luo HY, Li YH, Zhang DS, Jia WH, Chen G, Ding PR, Li LR, Lu ZH, Pan ZZ, Xu RH. Zhao Q, et al. Nat Commun. 2022 Apr 29;13(1):2342. doi: 10.1038/s41467-022-30062-8. Nat Commun. 2022. PMID: 35487942 Free PMC article.
We identify 46 high-confident significantly mutated genes, 8 of which mutate in 14.9% of patients: LYST, DAPK1, CR2, KIF16B, NPIPB15, SYTL2, ZNF91, and KIAA0586. With an unsupervised clustering algorithm, we propose a subtyping strategy that classisfies CRC patients into f …
We identify 46 high-confident significantly mutated genes, 8 of which mutate in 14.9% of patients: LYST, DAPK1, CR2, KIF16B, NPIPB15, SYT …
46 results