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16,593 results

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Page 1
Human T cell generation is restored in CD3delta severe combined immunodeficiency through adenine base editing.
McAuley GE, Yiu G, Chang PC, Newby GA, Campo-Fernandez B, Fitz-Gibbon ST, Wu X, Kang SL, Garibay A, Butler J, Christian V, Wong RL, Everette KA, Azzun A, Gelfer H, Seet CS, Narendran A, Murguia-Favela L, Romero Z, Wright N, Liu DR, Crooks GM, Kohn DB. McAuley GE, et al. Cell. 2023 Mar 30;186(7):1398-1416.e23. doi: 10.1016/j.cell.2023.02.027. Epub 2023 Mar 20. Cell. 2023. PMID: 36944331 Free PMC article.
Delivery of mRNA encoding a laboratory-evolved ABE and guide RNA into a CD3delta SCID patient's HSPCs resulted in a 71.2% 7.85% (n = 3) correction of the pathogenic mutation. ...These findings demonstrate the preclinical efficacy of ABE in HSPCs for the treatment of …
Delivery of mRNA encoding a laboratory-evolved ABE and guide RNA into a CD3delta SCID patient's HSPCs resulted in a 71.2% 7.85% (n = …
Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing.
He Y, Zhou X, Chang C, Chen G, Liu W, Li G, Fan X, Sun M, Miao C, Huang Q, Ma Y, Yuan F, Chang X. He Y, et al. Mol Cell. 2024 Apr 4;84(7):1257-1270.e6. doi: 10.1016/j.molcel.2024.01.021. Epub 2024 Feb 19. Mol Cell. 2024. PMID: 38377993 Free article.
Current base editors (BEs) use DNA deaminases, including cytidine deaminase in cytidine BE (CBE) or adenine deaminase in adenine BE (ABE), to facilitate transition nucleotide substitutions. Combining CBE or ABE with glycosylase enzymes can induce limited transversio …
Current base editors (BEs) use DNA deaminases, including cytidine deaminase in cytidine BE (CBE) or adenine deaminase in adenine BE (ABE …
Detection of protein palmitoylation in cultured hippocampal neurons by immunoprecipitation and acyl-biotin exchange (ABE).
Brigidi GS, Bamji SX. Brigidi GS, et al. J Vis Exp. 2013 Feb 18;(72):50031. doi: 10.3791/50031. J Vis Exp. 2013. PMID: 23438969 Free PMC article.
Purification of the thiol-biotinylated proteins following the ABE steps has differed, depending on the overall goal of the experiment. Here, we describe a method to purify a palmitoylated protein of interest in primary hippocampal neurons by an initial immunoprecipitation …
Purification of the thiol-biotinylated proteins following the ABE steps has differed, depending on the overall goal of the experiment …
Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy.
Nishiyama T, Zhang Y, Cui M, Li H, Sanchez-Ortiz E, McAnally JR, Tan W, Kim J, Chen K, Xu L, Bassel-Duby R, Olson EN. Nishiyama T, et al. Sci Transl Med. 2022 Nov 23;14(672):eade1633. doi: 10.1126/scitranslmed.ade1633. Epub 2022 Nov 23. Sci Transl Med. 2022. PMID: 36417486 Free PMC article.
Systemic delivery of ABE components containing ABEmax-VRQR-SpCas9 and single-guide RNA by adeno-associated virus serotype 9 in these mice restored cardiac function as assessed by echocardiography and extended life span. As seen by RNA sequencing analysis, ABE correc …
Systemic delivery of ABE components containing ABEmax-VRQR-SpCas9 and single-guide RNA by adeno-associated virus serotype 9 in these …
Butanol fermentation.
Schiel-Bengelsdorf B, Montoya J, Linder S, Dürre P. Schiel-Bengelsdorf B, et al. Environ Technol. 2013 Jul-Aug;34(13-16):1691-710. doi: 10.1080/09593330.2013.827746. Environ Technol. 2013. PMID: 24350428 Review.
The butanol fermentation using solventogenic clostridial strains, particularly Clostridium acetobutylicum, is a very old industrial process (acetone-butanol-ethanol-ABE fermentation). The genome of this organism has been sequenced and analysed, leading to important improve …
The butanol fermentation using solventogenic clostridial strains, particularly Clostridium acetobutylicum, is a very old industrial process …
Adenine base editor-based correction of the cardiac pathogenic Lmna c.1621C > T mutation in murine hearts.
Yang L, Liu Z, Sun J, Chen Z, Gao F, Guo Y. Yang L, et al. J Cell Mol Med. 2024 Feb;28(4):e18145. doi: 10.1111/jcmm.18145. J Cell Mol Med. 2024. PMID: 38332517 Free PMC article.
Despite the tremendous progress using ABEs to treat heart diseases, a standard technical route toward successful ABE-based therapy remains to be fully established. In this study, we harnessed adeno-associated virus (AAV) and a mouse model carrying the cardiomyopathy-causin …
Despite the tremendous progress using ABEs to treat heart diseases, a standard technical route toward successful ABE-based therapy re …
Genetic and functional correction of argininosuccinate lyase deficiency using CRISPR adenine base editors.
Jalil S, Keskinen T, Juutila J, Sartori Maldonado R, Euro L, Suomalainen A, Lapatto R, Kuuluvainen E, Hietakangas V, Otonkoski T, Hyvönen ME, Wartiovaara K. Jalil S, et al. Am J Hum Genet. 2024 Apr 4;111(4):714-728. doi: 10.1016/j.ajhg.2024.03.004. Am J Hum Genet. 2024. PMID: 38579669 Free PMC article.
To model ASLD, we first generated human-induced pluripotent stem cells (hiPSCs) from biopsies of individuals homozygous for the Finnish founder variant (c.1153C>T [p.Arg385Cys]) and edited this variant using the ABE. We then differentiated the hiPSCs into hepatoc …
To model ASLD, we first generated human-induced pluripotent stem cells (hiPSCs) from biopsies of individuals homozygous for the Finnish foun …
Targeting glycosylation of PD-1 to enhance CAR-T cell cytotoxicity.
Shi X, Zhang D, Li F, Zhang Z, Wang S, Xuan Y, Ping Y, Zhang Y. Shi X, et al. J Hematol Oncol. 2019 Nov 29;12(1):127. doi: 10.1186/s13045-019-0831-5. J Hematol Oncol. 2019. PMID: 31783892 Free PMC article.
Our results showed ABE editing altered the coding sequence of N74 residue of PDCD1 and downregulated PD-1 expression in CAR-T cells. Further analysis showed ABE-edited CAR-T cells had enhanced cytotoxic functions in vitro and in vivo. Our study suggest …
Our results showed ABE editing altered the coding sequence of N74 residue of PDCD1 and downregulated PD-1 expression in CAR-T …
Engineering E. coli to synthesize butanol.
Abdelaal AS, Yazdani SS. Abdelaal AS, et al. Biochem Soc Trans. 2022 Apr 29;50(2):867-876. doi: 10.1042/BST20211009. Biochem Soc Trans. 2022. PMID: 35356968 Review.
Butanol has been naturally produced via acetone-butanol-ethanol (ABE) fermentation by many Clostridium species, which are not very user-friendly bacteria. ...
Butanol has been naturally produced via acetone-butanol-ethanol (ABE) fermentation by many Clostridium species, which are not very us …
16,593 results
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