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1,583 results

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Page 1
Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-kappab pathway inactivation.
Shen Z, Zhao L, Yoo SA, Lin Z, Zhang Y, Yang W, Piao J. Shen Z, et al. Apoptosis. 2024 Oct;29(9-10):1810-1823. doi: 10.1007/s10495-024-01973-2. Epub 2024 May 5. Apoptosis. 2024. PMID: 38704789
Moreover, Emodin could inactivate NF-kappab pathway, and PMA, an activator of NF-kappab pathway could alleviate Emodin-induced ferroptosis in CRC cells. ...These findings not only identified a novel role for Emodin in ferroptosis but also indicated that Em …
Moreover, Emodin could inactivate NF-kappab pathway, and PMA, an activator of NF-kappab pathway could alleviate Emodin-induced …
Liposomal Emodin: A nanomedicine for two-photon imaging and mitochondria-targeted photodynamic therapy of psoriasis.
Sun J, Sun A, Wang Y, Xu X, Liu Y, Zhang C, Wang Y, Shang H, Li W. Sun J, et al. Biomaterials. 2026 Feb;325:123631. doi: 10.1016/j.biomaterials.2025.123631. Epub 2025 Aug 12. Biomaterials. 2026. PMID: 40829507 Free article.
Our proteomic and single-cell transcriptomic analyses reveal that LE downregulate macrophage mitochondrial electron transport chain proteins, inhibit inflammatory gene expression, and suppress the activity of inflammatory T cells and fibrosis, thereby improving the immune …
Our proteomic and single-cell transcriptomic analyses reveal that LE downregulate macrophage mitochondrial electron transport chain proteins …
The Raman Active Vibrational Modes of Anthraquinones.
Simeral ML, Hafner JH. Simeral ML, et al. Astrobiology. 2022 Oct;22(10):1165-1175. doi: 10.1089/ast.2021.0170. Epub 2022 Sep 7. Astrobiology. 2022. PMID: 36070545
In this study, we show that time-dependent density functional theory (TDDFT) can accurately calculate the Raman spectra of three dihydroxyanthraquinones: parietin, emodin, and chrysophanol. By comparing calculated spectra to measured Raman spectra from purified powders, 10 …
In this study, we show that time-dependent density functional theory (TDDFT) can accurately calculate the Raman spectra of three dihydroxyan …
Microbial production of the plant-derived fungicide physcion.
Qi F, Zhang W, Xue Y, Geng C, Jin Z, Li J, Guo Q, Huang X, Lu X. Qi F, et al. Metab Eng. 2022 Nov;74:130-138. doi: 10.1016/j.ymben.2022.10.007. Epub 2022 Nov 1. Metab Eng. 2022. PMID: 36328293
Here, a cell factory was constructed in the filamentous fungus Aspergillus terreus for physcion production via microbial fermentation by integrating a pathway-modified emodin accumulation module and a position-selective emodin methylation module. Specifically, 1.71 …
Here, a cell factory was constructed in the filamentous fungus Aspergillus terreus for physcion production via microbial fermentation by int …
Potential antineoplastic effects of Aloe-emodin: a comprehensive review.
Chen R, Zhang J, Hu Y, Wang S, Chen M, Wang Y. Chen R, et al. Am J Chin Med. 2014;42(2):275-88. doi: 10.1142/S0192415X14500189. Am J Chin Med. 2014. PMID: 24707862 Review.
Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have various pharmacological activities. ...
Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have …
Aloe-emodin alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis.
He Y, Xi J, Fang J, Zhang B, Cai W. He Y, et al. Free Radic Biol Med. 2023 Sep;206:13-21. doi: 10.1016/j.freeradbiomed.2023.06.025. Epub 2023 Jun 25. Free Radic Biol Med. 2023. PMID: 37364691
Aloe-emodin (AE), a novel ferroptosis inhibitor, alleviates the doxorubicin (DOX)-induced cardiotoxicity in H9c2 rat cardiomyocytes. ...
Aloe-emodin (AE), a novel ferroptosis inhibitor, alleviates the doxorubicin (DOX)-induced cardiotoxicity in H9c2 rat cardiomyocytes. …
Emodin enhances osteogenesis and inhibits adipogenesis.
Yang F, Yuan PW, Hao YQ, Lu ZM. Yang F, et al. BMC Complement Altern Med. 2014 Feb 24;14:74. doi: 10.1186/1472-6882-14-74. BMC Complement Altern Med. 2014. Retraction in: BMC Complement Med Ther. 2025 Jan 25;25(1):27. doi: 10.1186/s12906-025-04765-6. PMID: 24565373 Free PMC article. Retracted.
However, the underlying molecular mechanisms of emodin in modulating osteogenesis and adipogenesis remain poorly understood. METHODS: The molecular mechanisms of emodin on the processes of osteogenesis and adipogenesis in ovariectomized mouse and BMSCs (bone marrow …
However, the underlying molecular mechanisms of emodin in modulating osteogenesis and adipogenesis remain poorly understood. METHODS: …
The isomers, aloe-emodin and emodin, possess differential inhibitory activities against CYP1B1 enzyme.
Meng X, An X, Zhou L, Fu B, Jia L. Meng X, et al. Steroids. 2022 Sep;185:109055. doi: 10.1016/j.steroids.2022.109055. Epub 2022 Jun 2. Steroids. 2022. PMID: 35661798 Review.
Although isomeric, the IC50 values of aloe-emodin and emodin were 0.192 0.015 nM and 0.067 0.003 M, indicating the inhibition of aloe-emodin was about 350times stronger than that of emodin. ...This study reveals an anti-tumor mechanism of the anth …
Although isomeric, the IC50 values of aloe-emodin and emodin were 0.192 0.015 nM and 0.067 0.003 M, indicating the inhibi …
Study on the Hepatotoxicity of Emodin and Its Application in the Treatment of Liver Fibrosis.
Guo Y, Song J, Liu Y, Yuan M, Zhong W, Guo Y, Guo L. Guo Y, et al. Molecules. 2024 Oct 30;29(21):5122. doi: 10.3390/molecules29215122. Molecules. 2024. PMID: 39519763 Free PMC article.
In addition, the toxicity of EMO and E-T/LNPs was compared and the toxicity-efficacy concentrations of E-T/LNPs in zebrafish were verified. ...The combination and preparation can reduce the toxicity and enhance the effect of EMO, and increase the toxicity and effect …
In addition, the toxicity of EMO and E-T/LNPs was compared and the toxicity-efficacy concentrations of E-T/LNPs in zebrafish w …
Emodin-Based Nanoarchitectonics with Giant Two-Photon Absorption for Enhanced Photodynamic Therapy.
Liu Y, Zhao J, Xu X, Xu Y, Cui W, Yang Y, Li J. Liu Y, et al. Angew Chem Int Ed Engl. 2023 Aug 14;62(33):e202308019. doi: 10.1002/anie.202308019. Epub 2023 Jul 6. Angew Chem Int Ed Engl. 2023. PMID: 37358191
However, obtaining easily accessible TPE photosensitizers (PSs) with high efficiency remains a challenge. Herein, we demonstrate that emodin (Emo), a natural anthraquinone (NA) derivative, is a promising TPE PS with a large two-photon absorption cross-section (TPAC: 380.9 …
However, obtaining easily accessible TPE photosensitizers (PSs) with high efficiency remains a challenge. Herein, we demonstrate that emo …
1,583 results