Spatial transcriptomics identifies immune-stromal niches associated with cancer in adult dermatomyositis.
Anufrieva KS, Shahriari N, Gao C, Yiu SPT, Kazerounian S, Castillo RL, Liu J, Prell SA, Bhamidipati K, Afshari K, Parmelee L, Kazakova AN, Theisen E, Bowman T, LaChance A, Crisler WJ, Hashemi K, Korsunsky I, Jiang S, Rashighi M, Vleugels RA, Wei K.
Anufrieva KS, et al.
Nat Commun. 2026 Jun 26. doi: 10.1038/s41467-026-74871-7. Online ahead of print.
Nat Commun. 2026.
PMID: 42362560
Free article.
We find that cancer-associated DM skin lesions are distinguished by the presence of dispersed immune infiltrates enriched with macrophages or organized lymphoid aggregates with dense B cell cores surrounded by CD4 + /CD8 + T cells, accompanied by preserved vascular archite …
We find that cancer-associated DM skin lesions are distinguished by the presence of dispersed immune infiltrates enriched with macrophages o …