Novel aryl hydrocarbon receptor agonists as potential anti-inflammatory therapeutics: Identification and validation through drug repurposing.
Haupt J, Keminer O, Neser C, Windshügel B, Wiltzsch V, Schmidt JR, Pliushcheuskaya P, Künze G, Scholz U, Müller C, Oliveira da Rocha GH, Biermann MK, Zdzieblo D, Metzger M, Schiefke I, Neurath MF, Siegmund B, Claussen C, Köhl U, Geisslinger G, Buchholz M, Kalkhof S, Lehmann J.
Haupt J, et al.
Biochem Pharmacol. 2025 Oct;240:117066. doi: 10.1016/j.bcp.2025.117066. Epub 2025 Jun 24.
Biochem Pharmacol. 2025.
PMID: 40571216
Free article.
Out of these, 15 AhR ligands were selected based on substance class, half maximal effective concentration, known toxicity and pharmacokinetic/pharmacodynamic profiles, and preclinical/clinical evaluation status for other indications. While Febuxostat, Nitazoxanide, Rabepra …
Out of these, 15 AhR ligands were selected based on substance class, half maximal effective concentration, known toxicity and pharmacokineti …