Wnt-beta-catenin activation epigenetically reprograms T(reg) cells in inflammatory bowel disease and dysplastic progression.
Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari F.
Quandt J, et al.
Nat Immunol. 2021 Apr;22(4):471-484. doi: 10.1038/s41590-021-00889-2. Epub 2021 Mar 4.
Nat Immunol. 2021.
PMID: 33664518
Free PMC article.
The diversity of regulatory T (T(reg)) cells in health and in disease remains unclear. Individuals with colorectal cancer harbor a subpopulation of RORgammat(+) T(reg) cells with elevated expression of beta-catenin and pro-inflammatory properties. ...Activati …
The diversity of regulatory T (T(reg)) cells in health and in disease remains unclear. Individuals with colorectal cancer harb …