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Year Number of Results
1996 1
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1,823 results

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Page 1
Bile acid metabolites control T(H)17 and T(reg) cell differentiation.
Hang S, Paik D, Yao L, Kim E, Trinath J, Lu J, Ha S, Nelson BN, Kelly SP, Wu L, Zheng Y, Longman RS, Rastinejad F, Devlin AS, Krout MR, Fischbach MA, Littman DR, Huh JR. Hang S, et al. Nature. 2019 Dec;576(7785):143-148. doi: 10.1038/s41586-019-1785-z. Epub 2019 Nov 27. Nature. 2019. PMID: 31776512 Free PMC article.
The administration of 3-oxoLCA and isoalloLCA to mice reduced T(H)17 cell differentiation and increased T(reg) cell differentiation, respectively, in the intestinal lamina propria. Our data suggest mechanisms through which bile acid metabolites control host immune r …
The administration of 3-oxoLCA and isoalloLCA to mice reduced T(H)17 cell differentiation and increased T(reg) cell differenti …
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F. Dang EV, et al. Cell. 2011 Sep 2;146(5):772-84. doi: 10.1016/j.cell.2011.07.033. Epub 2011 Aug 25. Cell. 2011. PMID: 21871655 Free PMC article.
Here, we show that hypoxia-inducible factor 1 (HIF-1), a key metabolic sensor, regulates the balance between regulatory T cell (T(reg)) and T(H)17 differentiation. HIF-1 enhances T(H)17 development through direct transcriptional activation of RORgammat …
Here, we show that hypoxia-inducible factor 1 (HIF-1), a key metabolic sensor, regulates the balance between regulatory T cell (T(reg)) and …
Intratumoral dendritic cell-CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma.
Magen A, Hamon P, Fiaschi N, Soong BY, Park MD, Mattiuz R, Humblin E, Troncoso L, D'souza D, Dawson T, Kim J, Hamel S, Buckup M, Chang C, Tabachnikova A, Schwartz H, Malissen N, Lavin Y, Soares-Schanoski A, Giotti B, Hegde S, Ioannou G, Gonzalez-Kozlova E, Hennequin C, Le Berichel J, Zhao Z, Ward SC, Fiel I, Kou B, Dobosz M, Li L, Adler C, Ni M, Wei Y, Wang W, Atwal GS, Kundu K, Cygan KJ, Tsankov AM, Rahman A, Price C, Fernandez N, He J, Gupta NT, Kim-Schulze S, Gnjatic S, Kenigsberg E, Deering RP, Schwartz M, Marron TU, Thurston G, Kamphorst AO, Merad M. Magen A, et al. Nat Med. 2023 Jun;29(6):1389-1399. doi: 10.1038/s41591-023-02345-0. Epub 2023 Jun 15. Nat Med. 2023. PMID: 37322116 Free PMC article.
We found that these Progenitor CD8(+) T cells interact with CXCL13(+) T(H) within cellular triads around dendritic cells enriched in maturation and regulatory molecules, or "mregDC". These results suggest that discrete intratumoral niches that include mregDC and CXC …
We found that these Progenitor CD8(+) T cells interact with CXCL13(+) T(H) within cellular triads around dendritic cells enric …
Classification of human chronic inflammatory skin disease based on single-cell immune profiling.
Liu Y, Wang H, Taylor M, Cook C, Martínez-Berdeja A, North JP, Harirchian P, Hailer AA, Zhao Z, Ghadially R, Ricardo-Gonzalez RR, Grekin RC, Mauro TM, Kim E, Choi J, Purdom E, Cho RJ, Cheng JB. Liu Y, et al. Sci Immunol. 2022 Apr 15;7(70):eabl9165. doi: 10.1126/sciimmunol.abl9165. Epub 2022 Apr 15. Sci Immunol. 2022. PMID: 35427179 Free PMC article.
Transcript signatures differentiating these rash types included genes previously implicated in T helper cell (T(H)2)/T(H)17 diatheses, segregated in unbiased functional networks, and accurately identified disease class in untrained validation data sets …
Transcript signatures differentiating these rash types included genes previously implicated in T helper cell (T(H)2)/T( …
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites.
Paik D, Yao L, Zhang Y, Bae S, D'Agostino GD, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, Rakowski CK, Vlamakis H, Xavier RJ, Turnbaugh PJ, Longman RS, Krout MR, Clish CB, Rastinejad F, Huttenhower C, Huh JR, Devlin AS. Paik D, et al. Nature. 2022 Mar;603(7903):907-912. doi: 10.1038/s41586-022-04480-z. Epub 2022 Mar 16. Nature. 2022. PMID: 35296854 Free PMC article.
Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (T(H)17 cells). We previously reported that the bile acid metabolite 3-oxolithocholic acid (3-oxoLCA) inhibits T(H)17 cell differe …
Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (T(H …
Aberrant T follicular helper cells generated by T(H)17 cell plasticity in the gut promote extraintestinal autoimmunity.
Fan T, Tai C, Sleiman KC, Cutcliffe MP, Kim H, Liu Y, Li J, Xin G, Grashel M, Baert L, Ekeocha C, Vergenes P, Lima S, Lo WL, Lin J, Hanaoka B, Tankersley TN, Wang M, Zhang X, Tsokos GC, Jarjour W, Longman R, Wu HJ. Fan T, et al. Nat Immunol. 2025 May;26(5):790-804. doi: 10.1038/s41590-025-02125-7. Epub 2025 Apr 30. Nat Immunol. 2025. PMID: 40307450
Functional analyses using fate-mapping mice revealed a c-Maf-dependent and SFB-induced T(H)17-to-T(FH) cell reprogramming that dominantly occurs in PPs. Unlike conventional T(FH) cells, T(H)17-derived T(FH) cells are highly migratory and atypically con …
Functional analyses using fate-mapping mice revealed a c-Maf-dependent and SFB-induced T(H)17-to-T(FH) cell reprogramming that …
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.
Kim S, Kim H, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB, Huh JR. Kim S, et al. Nature. 2017 Sep 28;549(7673):528-532. doi: 10.1038/nature23910. Epub 2017 Sep 13. Nature. 2017. PMID: 28902840 Free PMC article.
In pregnant mice, interleukin-17a (IL-17a) produced by T helper 17 (T(H)17) cells (CD4(+) T helper effector cells involved in multiple inflammatory conditions) induces behavioural and cortical abnormalities in the offspring exposed to MIA. ...Here we show that MIA p …
In pregnant mice, interleukin-17a (IL-17a) produced by T helper 17 (T(H)17) cells (CD4(+) T helper effector cells involved in …
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity.
Lee WS, Yang H, Chon HJ, Kim C. Lee WS, et al. Exp Mol Med. 2020 Sep;52(9):1475-1485. doi: 10.1038/s12276-020-00500-y. Epub 2020 Sep 11. Exp Mol Med. 2020. PMID: 32913278 Free PMC article. Review.
Protumoral M2-like macrophages as well as T(H)2 and Treg cells secrete pro-angiogenic factors that accelerate uncontrolled angiogenesis and promote vascular immaturity. While CD8(+) T and CD4(+) T(H)1 cells suppress angiogenesis and induce vascular mat …
Protumoral M2-like macrophages as well as T(H)2 and Treg cells secrete pro-angiogenic factors that accelerate uncontrolled ang …
JAK3 inhibitor suppresses multipotent ILC2s and attenuates steroid-resistant asthma.
Kim J, Ham J, Kang HR, Bae YS, Kim T, Kim HY. Kim J, et al. Sci Adv. 2023 Dec 22;9(51):eadi3770. doi: 10.1126/sciadv.adi3770. Epub 2023 Dec 20. Sci Adv. 2023. PMID: 38117887 Free PMC article.
Group 2 innate lymphoid cells (ILC2s), such as T helper 2 (T(H)2) cells, produce key asthma-related type 2 cytokines. Recent insights from mouse and human studies indicate a potential connection between ILC2s and steroid-resistant asthma. Here, we highlight that lun …
Group 2 innate lymphoid cells (ILC2s), such as T helper 2 (T(H)2) cells, produce key asthma-related type 2 cytokines. Recent i …
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis.
Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K. Doke T, et al. Nat Immunol. 2022 Jun;23(6):947-959. doi: 10.1038/s41590-022-01200-7. Epub 2022 May 12. Nat Immunol. 2022. PMID: 35552540 Free PMC article.
In mice, these basophils are an important source of interleukin-6 and recruitment of the T(H)17 subset of helper T cells. Genetic deletion or antibody-based depletion of basophils results in reduced renal fibrosis. ...
In mice, these basophils are an important source of interleukin-6 and recruitment of the T(H)17 subset of helper T cells. Gene …
1,823 results