Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1881 1
1883 1
1886 1
1895 2
1898 1
1911 1
1920 2
1924 2
1928 1
1931 1
1935 1
1939 2
1940 1
1941 1
1944 1
1946 2
1947 1
1948 1
1949 4
1950 1
1951 2
1952 3
1953 1
1954 3
1955 3
1957 1
1958 3
1959 3
1960 7
1961 8
1962 5
1963 10
1964 24
1965 16
1966 20
1967 15
1968 11
1969 18
1970 25
1971 14
1972 11
1973 21
1974 23
1975 14
1976 17
1977 14
1978 14
1979 24
1980 15
1981 12
1982 10
1983 19
1984 15
1985 8
1986 21
1987 6
1988 8
1989 10
1990 15
1991 20
1992 23
1993 26
1994 14
1995 14
1996 19
1997 18
1998 23
1999 25
2000 18
2001 17
2002 26
2003 25
2004 19
2005 25
2006 19
2007 32
2008 24
2009 18
2010 29
2011 26
2012 32
2013 31
2014 17
2015 32
2016 34
2017 30
2018 24
2019 25
2020 33
2021 33
2022 26
2023 30
2024 30
2025 20
2026 7

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,345 results

Results by year

Filters applied: . Clear all
Page 1
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.
Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P. Martinez Molina D, et al. Science. 2013 Jul 5;341(6141):84-7. doi: 10.1126/science.1233606. Science. 2013. PMID: 23828940
We have developed a method for evaluating drug binding to target proteins in cells and tissue samples. This cellular thermal shift assay (CETSA) is based on the biophysical principle of ligand-induced thermal stabilization of target proteins. ...
We have developed a method for evaluating drug binding to target proteins in cells and tissue samples. This cellular thermal shift as …
A chemically functionalizable nanoporous material.
Chui SS, Lo SM, Charmant JP, Orpen AG, Williams ID. Chui SS, et al. Science. 1999 Feb 19;283(5405):1148-50. doi: 10.1126/science.283.5405.1148. Science. 1999. PMID: 10024237
Although zeolites and related materials combine nanoporosity with high thermal stability, they are difficult to modify or derivatize in a systematic way. A highly porous metal coordination polymer [Cu3(TMA)2(H2O)3]n (where TMA is benzene-1,3,5-tricarboxylate) was formed in …
Although zeolites and related materials combine nanoporosity with high thermal stability, they are difficult to modify or derivatize …
Tracking cancer drugs in living cells by thermal profiling of the proteome.
Savitski MM, Reinhard FB, Franken H, Werner T, Savitski MF, Eberhard D, Martinez Molina D, Jafari R, Dovega RB, Klaeger S, Kuster B, Nordlund P, Bantscheff M, Drewes G. Savitski MM, et al. Science. 2014 Oct 3;346(6205):1255784. doi: 10.1126/science.1255784. Epub 2014 Oct 2. Science. 2014. PMID: 25278616
The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determining the thermal profiles of more than 7000 proteins in human cells by means of mass spectrometry. ...Thermal proteome profiling …
The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determini …
Phytochrome B integrates light and temperature signals in Arabidopsis.
Legris M, Klose C, Burgie ES, Rojas CC, Neme M, Hiltbrunner A, Wigge PA, Schäfer E, Vierstra RD, Casal JJ. Legris M, et al. Science. 2016 Nov 18;354(6314):897-900. doi: 10.1126/science.aaf5656. Epub 2016 Oct 27. Science. 2016. PMID: 27789798
Here, we demonstrate that the phytochrome B (phyB) photoreceptor participates in temperature perception through its temperature-dependent reversion from the active Pfr state to the inactive Pr state. Increased rates of thermal reversion upon exposing Arabidopsis seedlings …
Here, we demonstrate that the phytochrome B (phyB) photoreceptor participates in temperature perception through its temperature-dependent re …
Impaired nociception and pain sensation in mice lacking the capsaicin receptor.
Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Caterina MJ, et al. Science. 2000 Apr 14;288(5464):306-13. doi: 10.1126/science.288.5464.306. Science. 2000. PMID: 10764638
Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known. Here, we demonstrate that sensory neurons from mice lacking VR1 are seve …
Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contribu …
Electrochemical waste-heat harvesting.
Yu B, Duan J. Yu B, et al. Science. 2023 Jul 21;381(6655):269-270. doi: 10.1126/science.adi8036. Epub 2023 Jul 20. Science. 2023. PMID: 37471554
A combined thermal and electrochemical device enhances voltage and hydrogen production....
A combined thermal and electrochemical device enhances voltage and hydrogen production....
Strain-programmable fiber-based artificial muscle.
Kanik M, Orguc S, Varnavides G, Kim J, Benavides T, Gonzalez D, Akintilo T, Tasan CC, Chandrakasan AP, Fink Y, Anikeeva P. Kanik M, et al. Science. 2019 Jul 12;365(6449):145-150. doi: 10.1126/science.aaw2502. Science. 2019. PMID: 31296764 Free PMC article.
We applied a high-throughput iterative fiber-drawing technique to create strain-programmable artificial muscles with dimensions spanning three orders of magnitude. These fiber-based actuators are thermally and optically controllable, can lift more than 650 times their own …
We applied a high-throughput iterative fiber-drawing technique to create strain-programmable artificial muscles with dimensions spanning thr …
Optomechanical dark mode.
Dong C, Fiore V, Kuzyk MC, Wang H. Dong C, et al. Science. 2012 Dec 21;338(6114):1609-13. doi: 10.1126/science.1228370. Epub 2012 Nov 15. Science. 2012. PMID: 23160956
Thermal mechanical motion hinders the use of a mechanical system in applications such as quantum information processing. Whereas the thermal motion can be overcome by cooling a mechanical oscillator to its motional ground state, an alternative approach is to exploit …
Thermal mechanical motion hinders the use of a mechanical system in applications such as quantum information processing. Whereas the …
BETA-CAROTENE: THERMAL DEGRADATION.
MADER I. MADER I. Science. 1964 May 1;144(3618):533-4. doi: 10.1126/science.144.3618.533. Science. 1964. PMID: 14194098
Thermal treatment of crystalline beta-carotene (240 degrees C in a vacuum) results in the formation of a volatile fraction containing chiefly aromatic hydrocarbons such as toluene, m- and p-xylene, 2,6-dimethylnaphthalene, and ionene. ...
Thermal treatment of crystalline beta-carotene (240 degrees C in a vacuum) results in the formation of a volatile fraction containing …
Localized thermal emission from topological interfaces.
Ergoktas MS, Kecebas A, Despotelis K, Soleymani S, Bakan G, Kocabas A, Principi A, Rotter S, Ozdemir SK, Kocabas C. Ergoktas MS, et al. Science. 2024 Jun 7;384(6700):1122-1126. doi: 10.1126/science.ado0534. Epub 2024 Jun 6. Science. 2024. PMID: 38843319 Free PMC article.
The control of thermal radiation by shaping its spatial and spectral emission characteristics plays a key role in many areas of science and engineering. ...The boundaries between subcritical and supercritical spatial domains host topological interface states with near-unit …
The control of thermal radiation by shaping its spatial and spectral emission characteristics plays a key role in many areas of scien …
1,345 results