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Strategies for dealing with metabolite elucidation in drug discovery and development.

Nassar AE, Talaat RE. Nassar AE, et al. Among authors: talaat re. Drug Discov Today. 2004 Apr 1;9(7):317-27. doi: 10.1016/S1359-6446(03)03018-6. Drug Discov Today. 2004. PMID: 15037231 Review.

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The impact of recent innovations in the use of liquid chromatography-mass spectrometry in support of drug metabolism studies: are we all the way there yet?

Nassar AE, Talaat RE, Kamel AM. Nassar AE, et al. Among authors: talaat re. Curr Opin Drug Discov Devel. 2006 Jan;9(1):61-74. Curr Opin Drug Discov Devel. 2006. PMID: 16445118 Review.

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Spectral accuracy of molecular ions in an LTQ/Orbitrap mass spectrometer and implications for elemental composition determination.

Erve JC, Gu M, Wang Y, DeMaio W, Talaat RE. Erve JC, et al. Among authors: talaat re. J Am Soc Mass Spectrom. 2009 Nov;20(11):2058-69. doi: 10.1016/j.jasms.2009.07.014. Epub 2009 Jul 30. J Am Soc Mass Spectrom. 2009. PMID: 19716315 Free article.

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Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.

He K, Talaat RE, Woolf TF. He K, et al. Among authors: talaat re. Drug Metab Dispos. 2004 Apr;32(4):442-6. doi: 10.1124/dmd.32.4.442. Drug Metab Dispos. 2004. PMID: 15039298

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Liquid chromatography/mass spectrometry determination of endogenous plasma acetyl and palmitoyl carnitines as potential biomarkers of beta-oxidation in mice.

Liu Z, Mutlib AE, Wang J, Talaat RE. Liu Z, et al. Among authors: talaat re. Rapid Commun Mass Spectrom. 2008 Nov;22(21):3434-42. doi: 10.1002/rcm.3755. Rapid Commun Mass Spectrom. 2008. PMID: 18837479

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Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.

He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF. He K, et al. Among authors: talaat re. Drug Metab Dispos. 2004 Jun;32(6):639-46. doi: 10.1124/dmd.32.6.639. Drug Metab Dispos. 2004. PMID: 15155556

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Formation and reversibility of S-linked conjugates of N-(1-methyl-3,3-diphenylpropyl)isocyanate, an in vivo metabolite of N-(1-methyl-3,3-diphenylpropyl)formamaide, in rats.

Mutlib AE, Talaat RE, Slatter JG, Abbott FS. Mutlib AE, et al. Among authors: talaat re. Drug Metab Dispos. 1990 Nov-Dec;18(6):1038-45. Drug Metab Dispos. 1990. PMID: 1981510

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Metabolism of prazosin in rat and characterization of metabolites in plasma, urine, faeces, brain and bile using liquid chromatography/mass spectrometry (LC/MS).

Erve JC, Vashishtha SC, Ojewoye O, Adedoyin A, Espina R, Demaio W, Talaat RE. Erve JC, et al. Among authors: talaat re. Xenobiotica. 2008 May;38(5):540-58. doi: 10.1080/00498250802001826. Xenobiotica. 2008. PMID: 18421626

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Metabolite identification in rat brain microdialysates by direct infusion nanoelectrospray ionization after desalting on a ZipTip and LTQ/Orbitrap mass spectrometry.

Erve JC, Beyer CE, Manzino L, Talaat RE. Erve JC, et al. Among authors: talaat re. Rapid Commun Mass Spectrom. 2009 Dec;23(24):4003-12. doi: 10.1002/rcm.4341. Rapid Commun Mass Spectrom. 2009. PMID: 19918933

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Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.

Erve JC, Vashishtha SC, DeMaio W, Talaat RE. Erve JC, et al. Among authors: talaat re. Drug Metab Dispos. 2007 Jun;35(6):908-16. doi: 10.1124/dmd.106.013219. Epub 2007 Mar 12. Drug Metab Dispos. 2007. PMID: 17353349

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