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The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness.
Serrano J, Boyd J, Mason C, Smith KR, Karolyi K, Kondo S, Brown IS, Maurya SK, Meshram NN, Serna V, Gilger J, Branch DA, Gardell SJ, Baskin KK, Ayala JE, Pratley RE, Goodpaster BH, Coen PM, Kyriazis GA. Serrano J, et al. Res Sq [Preprint]. 2023 Feb 9:rs.3.rs-2475555. doi: 10.21203/rs.3.rs-2475555/v1. Res Sq. 2023. PMID: 36798161 Free PMC article. Preprint.
Deletion of TAS1R2 in obese or aged mice also ameliorated the decline in muscle mass and fitness arising from these conditions. ...Our findings show that inhibition of the TAS1R2 signaling in skeletal muscle is a promising therapeutic approach to preserve muscle mas …
Deletion of TAS1R2 in obese or aged mice also ameliorated the decline in muscle mass and fitness arising from these conditions. ...Ou …
TAS1R2 sweet taste receptor genetic variation and dietary intake in Korean females.
Choi JH. Choi JH. Appetite. 2021 Sep 1;164:105281. doi: 10.1016/j.appet.2021.105281. Epub 2021 Apr 27. Appetite. 2021. PMID: 33930495
Taste receptor type 1, member 2 (TAS1R2) controls the oral sensing of sweetness. Genetic variations in TAS1R2 have been shown to be associated with differential sweetness intensity and varying carbohydrate intake levels among individuals. This study examined whether …
Taste receptor type 1, member 2 (TAS1R2) controls the oral sensing of sweetness. Genetic variations in TAS1R2 have been shown …
TAS1R2 rs35874116 and TRPM5 rs886277 polymorphisms are not related with risk of obesity.
Koc G, Soyocak A, Andac-Ozturk S. Koc G, et al. Int J Clin Pract. 2021 Sep;75(9):e14562. doi: 10.1111/ijcp.14562. Epub 2021 Jul 5. Int J Clin Pract. 2021. PMID: 34157195
We hypothesised that genetic variations in TAS1R2 and TRPM5 genes may contribute to obesity phenotypes by influencing food intake and body mass index (BMI). ...CONCLUSIONS: Although TAS1R2 and TRPM5 genes were associated with taste preferences in previous studies, w …
We hypothesised that genetic variations in TAS1R2 and TRPM5 genes may contribute to obesity phenotypes by influencing food intake and …
The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial capacity.
Serrano J, Boyd J, Brown IS, Mason C, Smith KR, Karolyi K, Maurya SK, Meshram NN, Serna V, Link GM, Gardell SJ, Kyriazis GA. Serrano J, et al. Nat Commun. 2024 Jun 8;15(1):4915. doi: 10.1038/s41467-024-49100-8. Nat Commun. 2024. PMID: 38851747 Free PMC article.
Plasma glucose levels negatively correlate with muscle NAD, and TAS1R2 receptor deficiency enhances NAD responses across the glycemic range, implicating TAS1R2 as a peripheral energy surveyor. These findings underscore the role of GPCR signaling in NAD regulation an …
Plasma glucose levels negatively correlate with muscle NAD, and TAS1R2 receptor deficiency enhances NAD responses across the glycemic …
G Protein-Coupled Receptors in Taste Physiology and Pharmacology.
Ahmad R, Dalziel JE. Ahmad R, et al. Front Pharmacol. 2020 Nov 30;11:587664. doi: 10.3389/fphar.2020.587664. eCollection 2020. Front Pharmacol. 2020. PMID: 33390961 Free PMC article. Review.
Type I taste GPCRs (TAS1R) form heterodimeric complexes that function as sweet (TAS1R2/TAS1R3) or umami (TAS1R1/TAS1R3) taste receptors, whereas Type II are monomeric bitter taste receptors or kokumi/calcium-sensing receptors. ...
Type I taste GPCRs (TAS1R) form heterodimeric complexes that function as sweet (TAS1R2/TAS1R3) or umami (TAS1R1/TAS1R3) taste recepto …
Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.
Kiliç M, Gurbuz T, Kahraman CY, Cayir A, Bilgiç A, Kurt Y. Kiliç M, et al. Dent Med Probl. 2022 Apr-Jun;59(2):233-240. doi: 10.17219/dmp/143252. Dent Med Probl. 2022. PMID: 35510485 Free article.
OBJECTIVES: The aim of the study was to investigate the effects of the polymorphisms of TAS2R38 (the bitter taste gene) and TAS1R2 (the sweet taste gene), which are the most important members of the taste gene family, on the dental status of obese and normal-weight childre …
OBJECTIVES: The aim of the study was to investigate the effects of the polymorphisms of TAS2R38 (the bitter taste gene) and TAS1R2 (t …
Taste and chirality: l-glucose sweetness is mediated by TAS1R2/TAS2R3 receptor.
Dubovski N, Ben Shoshan-Galeczki Y, Malach E, Niv MY. Dubovski N, et al. Food Chem. 2022 Mar 30;373(Pt A):131393. doi: 10.1016/j.foodchem.2021.131393. Epub 2021 Oct 13. Food Chem. 2022. PMID: 34715629
We demonstrate that l-glucose acts via the sweet taste receptor TAS1R2/TAS1R3, eliciting a dose-dependent activation in cell-based functional assays. Computational docking of glucose to the VFT domain of TAS1R2 suggests two sub-pockets, each compatible with each of …
We demonstrate that l-glucose acts via the sweet taste receptor TAS1R2/TAS1R3, eliciting a dose-dependent activation in cell-based fu …
Sweet taste perception in mice is blunted by PTBP1-regulated skipping of Tas1r2 exon 4.
Zheng X, Zhu J, Liu J, Wang H, Qin Y, Jiang P, Xiao L, Gong T, Li Y, Peng X, Xu X, Cheng L, Huang L, Chen Q, Zhou X, Margolskee RF. Zheng X, et al. Chem Senses. 2022 Jan 1;47:bjac034. doi: 10.1093/chemse/bjac034. Chem Senses. 2022. PMID: 36484118
Here, we report the identification of a novel splicing variant of sweet taste receptor gene Tas1r2 (Tas1r2_e4) in mouse taste buds and the mechanism by which it diminishes sweet taste responses in vitro and in vivo. ...The splicing factor PTBP1 (polypyrimidine tract …
Here, we report the identification of a novel splicing variant of sweet taste receptor gene Tas1r2 (Tas1r2_e4) in mouse taste …
Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.
Hoti Q, Akan G, Tuncel G, Evren EU, Evren H, Suer K, Sanlidag T, Ergoren MC. Hoti Q, et al. Mol Biol Rep. 2023 Nov;50(11):9343-9351. doi: 10.1007/s11033-023-08893-5. Epub 2023 Oct 10. Mol Biol Rep. 2023. PMID: 37817023
RESULTS: The expression levels of TAS1R2 and TAS1R3 genes were significantly decreased in COVID-19 patients who were infected with Delta variant. ...CONCLUSION: TAS1R2, TAS1R3, and TAS2R38 gene expression levels were decreased in the Delta variant compared to the Om …
RESULTS: The expression levels of TAS1R2 and TAS1R3 genes were significantly decreased in COVID-19 patients who were infected with De …
146 results