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197 results

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Page 1
Innovative biomarkers TCN2 and LY6E can significantly inhibit respiratory syncytial virus infection.
Cao B, Li M, Li X, Ji X, Wan L, Jiang Y, Zhou L, Gong F, Chen X. Cao B, et al. J Transl Med. 2024 Sep 23;22(1):854. doi: 10.1186/s12967-024-05677-8. J Transl Med. 2024. PMID: 39313785 Free PMC article.
Additionally, our data revealed an upregulation of LY6E and TCN2 expression in PBMCs from patients with RSV infection. ROC analysis indicated that LY6E and TCN2 possessed diagnostic value for RSV infection. ...LY6E and TCN2 inhibit RSV infection, indicating t …
Additionally, our data revealed an upregulation of LY6E and TCN2 expression in PBMCs from patients with RSV infection. ROC analysis i …
FTY720 requires vitamin B(12)-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis.
Jonnalagadda D, Kihara Y, Groves A, Ray M, Saha A, Ellington C, Lee-Okada HC, Furihata T, Yokomizo T, Quadros EV, Rivera R, Chun J. Jonnalagadda D, et al. Cell Rep. 2023 Dec 26;42(12):113545. doi: 10.1016/j.celrep.2023.113545. Epub 2023 Dec 7. Cell Rep. 2023. PMID: 38064339 Free PMC article.
Deficiency of CD320 or dietary B(12) restriction worsens EAE and eliminates FTY720's efficacy while concomitantly downregulating type I interferon signaling. TCN2 functions as a chaperone for FTY720 and sphingosine, whose complex induces astrocytic CD320 internalization, s …
Deficiency of CD320 or dietary B(12) restriction worsens EAE and eliminates FTY720's efficacy while concomitantly downregulating type I inte …
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL. Oussalah A, et al. Am J Clin Nutr. 2017 Oct;106(4):1142-1156. doi: 10.3945/ajcn.117.156349. Epub 2017 Aug 16. Am J Clin Nutr. 2017. PMID: 28814397 Free PMC article.
Approximately 20-25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is referred to as active vitamin B-12. The G allele of the TCN2 c.776G>C (rs1801198) polymorphism has been associated with a lower plasma concentration of holotranscobalamin. .. …
Approximately 20-25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is referred to as active vitamin B-12. The G al …
Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease.
Ge YJ, Chen SD, Wu BS, Zhang YR, Wang J, He XY, Liu WS, Chen YL, Ou YN, Shen XN, Huang YY, Gan YH, Yang L, Ma LZ, Ma YH, Chen KL, Chen SF, Cui M, Tan L, Dong Q, Zhao QH, Wang YJ, Jia JP, Yu JT. Ge YJ, et al. Alzheimers Dement. 2024 Sep;20(9):6243-6256. doi: 10.1002/alz.14121. Epub 2024 Jul 18. Alzheimers Dement. 2024. PMID: 39023044 Free PMC article.
HIGHLIGHTS: Loci KIAA2013, SLC52A3, and TCN2 were associated with Alzheimer's disease (AD) in Chinese populations. rs1815157 within the EGFR locus was associated with AD in Chinese populations. The genetic architecture of AD varied between Chinese and European populations. …
HIGHLIGHTS: Loci KIAA2013, SLC52A3, and TCN2 were associated with Alzheimer's disease (AD) in Chinese populations. rs1815157 within t …
Transcobalamin II deficiency in twins with a novel variant in the TCN2 gene: case report and review of literature.
Kose E, Besci O, Gudeloglu E, Suncak S, Oymak Y, Ozen S, Isguder R. Kose E, et al. J Pediatr Endocrinol Metab. 2020 Nov 26;33(11):1487-1499. doi: 10.1515/jpem-2020-0096. J Pediatr Endocrinol Metab. 2020. PMID: 32841161 Free article. Review.
In this report, we presented twins with TCN2 gene mutation. Both patients emphasized that early and aggressive treatment is crucial for achieving optimal outcomes. In this report, we identified a novel variation in TCN2 gene....
In this report, we presented twins with TCN2 gene mutation. Both patients emphasized that early and aggressive treatment is crucial f …
A novel TCN2 mutation with unusual clinical manifestations of hemolytic crisis and unexplained metabolic acidosis: expanding the genotype and phenotype of transcobalamin II deficiency.
Pongphitcha P, Sirachainan N, Khongkraparn A, Tim-Aroon T, Songdej D, Wattanasirichaigoon D. Pongphitcha P, et al. BMC Pediatr. 2022 Apr 29;22(1):233. doi: 10.1186/s12887-022-03291-5. BMC Pediatr. 2022. PMID: 35488219 Free PMC article.
Whole exome sequencing identified a novel homozygous TCN2 mutation, c.428-2A > G and mRNA study confirmed an aberrant transcription of exon 4 skipping. ...
Whole exome sequencing identified a novel homozygous TCN2 mutation, c.428-2A > G and mRNA study confirmed an aberrant transcriptio …
Transcobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism.
Liu B, Li A, Liu Y, Zhou X, Xu J, Zuo X, Xue K, Cui Y. Liu B, et al. Front Immunol. 2024 May 31;15:1339680. doi: 10.3389/fimmu.2024.1339680. eCollection 2024. Front Immunol. 2024. PMID: 38881906 Free PMC article.
TCN2 heterozygous knockout THP1 cells were used to explore the effects of TCN2 dysfunction on monocytes. ...Using CD14+ monocytes and TCN2 genetically modified THP1 cell lines, we found that the TCN2 was induced by LPS in serum from SLE patients. ...
TCN2 heterozygous knockout THP1 cells were used to explore the effects of TCN2 dysfunction on monocytes. ...Using CD14+ monocy …
Loss of the Vitamin B-12 Transport Protein Tcn2 Results in Maternally Inherited Growth and Developmental Defects in Zebrafish.
Benoit CR, Walsh DJ, Mekerishvili L, Houerbi N, Stanton AE, McGaughey DM, Brody LC. Benoit CR, et al. J Nutr. 2021 Sep 4;151(9):2522-2532. doi: 10.1093/jn/nxab151. J Nutr. 2021. PMID: 34132337 Free PMC article.
OBJECTIVES: Given the orthologous relation between zebrafish Tcn2 and human transcobalamin, we hypothesized that zebrafish carrying null mutations of tcn2 would exhibit phenotypes consistent with vitamin B-12 deficiency. ...When first-generation female tcn2-/ …
OBJECTIVES: Given the orthologous relation between zebrafish Tcn2 and human transcobalamin, we hypothesized that zebrafish carrying n …
Prioritization of drug targets for thyroid cancer: a multi-omics Mendelian randomization study.
Sun H, Li L, Yan J, Huang T. Sun H, et al. Endocrine. 2024 Nov;86(2):732-743. doi: 10.1007/s12020-024-03933-x. Epub 2024 Jun 19. Endocrine. 2024. PMID: 38896366
RESULTS: SDCCAG8 and VCAM1 genes were associated with risk of thyroid cancer with tier 1 evidence, while TCN2 gene was with tier 3 evidence. SDCCAG8 gene was associated with risk of papillary thyroid cancer with tier 1 evidence. ...The bioinformatics analysis showed that S …
RESULTS: SDCCAG8 and VCAM1 genes were associated with risk of thyroid cancer with tier 1 evidence, while TCN2 gene was with tier 3 ev …
Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets.
Grarup N, Sulem P, Sandholt CH, Thorleifsson G, Ahluwalia TS, Steinthorsdottir V, Bjarnason H, Gudbjartsson DF, Magnusson OT, Sparsø T, Albrechtsen A, Kong A, Masson G, Tian G, Cao H, Nie C, Kristiansen K, Husemoen LL, Thuesen B, Li Y, Nielsen R, Linneberg A, Olafsson I, Eyjolfsson GI, Jørgensen T, Wang J, Hansen T, Thorsteinsdottir U, Stefánsson K, Pedersen O. Grarup N, et al. PLoS Genet. 2013 Jun;9(6):e1003530. doi: 10.1371/journal.pgen.1003530. Epub 2013 Jun 6. PLoS Genet. 2013. PMID: 23754956 Free PMC article.
We found six novel loci associating with serum B(12) (CD320, TCN2, ABCD4, MMAA, MMACHC) or folate levels (FOLR3) and confirmed seven loci for these traits (TCN1, FUT6, FUT2, CUBN, CLYBL, MUT, MTHFR). ...
We found six novel loci associating with serum B(12) (CD320, TCN2, ABCD4, MMAA, MMACHC) or folate levels (FOLR3) and confirmed seven …
197 results