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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1973 1
1974 2
1976 1
1978 2
1979 1
1980 2
1981 2
1982 1
1983 1
1984 1
1985 2
1986 1
1987 2
1988 1
1989 2
1990 2
1991 2
1992 1
1993 5
1994 1
1995 3
1997 2
1998 2
1999 4
2000 6
2001 7
2002 3
2003 6
2004 7
2005 3
2006 5
2007 9
2008 9
2009 10
2010 9
2011 11
2012 15
2013 16
2014 22
2015 13
2016 14
2017 22
2018 26
2019 26
2020 32
2021 41
2022 30
2023 28
2024 26
2025 30
2026 28

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437 results

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Page 1
Spatiotemporal Adaptations-Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response.
Li Z, Tan J, Zhou C, Zhou S, Ye Y, Li X, Shen X, Xie T, Wang M, Jiang J, Zhao Y, Xiang X, Zhou Y, Wu J, Chuong CM, Lei M. Li Z, et al. Adv Sci (Weinh). 2025 Sep;12(34):e06651. doi: 10.1002/advs.202506651. Epub 2025 Jun 25. Adv Sci (Weinh). 2025. PMID: 40558382 Free PMC article.
In the subsequent phase, dermal Thra mediates the Serum Amyloid A3 (SAA3)-Fibronectin 1 (FN1) interaction, establishing angiogenic niches essential for matrix maturation. Using the self-assembled epidermis-dermis dynamic skin organoid model, Thra's role in simulatin …
In the subsequent phase, dermal Thra mediates the Serum Amyloid A3 (SAA3)-Fibronectin 1 (FN1) interaction, establishing angiogenic ni …
Thyroid hormone receptors and resistance to thyroid hormone disorders.
Ortiga-Carvalho TM, Sidhaye AR, Wondisford FE. Ortiga-Carvalho TM, et al. Nat Rev Endocrinol. 2014 Oct;10(10):582-91. doi: 10.1038/nrendo.2014.143. Epub 2014 Aug 19. Nat Rev Endocrinol. 2014. PMID: 25135573 Free PMC article. Review.
The introduction of the same mutations that mimic human THRbeta alterations into the mouse Thra and Thrb genes resulted in distinct phenotypes, which suggests that THRA and THRB might have non-overlapping functions in human physiology. These studies also suggested t …
The introduction of the same mutations that mimic human THRbeta alterations into the mouse Thra and Thrb genes resulted in distinct p …
THRA Orchestrates Myocardial Protection Against Hypothyroidism-Induced Ferroptosis via the GATA4-GPX4 Transcriptional Cascade.
Runfang Z, Fa X. Runfang Z, et al. Antioxid Redox Signal. 2026 Feb;44(4-6):236-250. doi: 10.1177/15230864251399166. Epub 2025 Nov 26. Antioxid Redox Signal. 2026. PMID: 41313662
AIMS: Hypothyroidism frequently causes myocardial injury, but the role of thyroid hormone receptor alpha (THRA) remains unclear. This study investigated the function and mechanism of THRA in hypothyroidism-associated cardiac damage. ...Mechanistically, we identified …
AIMS: Hypothyroidism frequently causes myocardial injury, but the role of thyroid hormone receptor alpha (THRA) remains unclear. This …
Thyroid hormone receptor Thra and Thrb knockout differentially affects osteoblast biology and thyroid hormone responsiveness in vitro.
Lademann F, Tsourdi E, Hofbauer LC, Rauner M. Lademann F, et al. J Cell Biochem. 2023 Dec;124(12):1948-1960. doi: 10.1002/jcb.30500. Epub 2023 Nov 22. J Cell Biochem. 2023. PMID: 37992217
TH actions on bone are mediated by the thyroid hormone receptors (TR) TRalpha1 and TRbeta1, encoded by Thra and Thrb, respectively. Skeletal phenotypes of mice lacking Thra (Thra(0/0) ) and Thrb (Thrb(-/-) ) are well-described and suggest that TRalpha1 is the …
TH actions on bone are mediated by the thyroid hormone receptors (TR) TRalpha1 and TRbeta1, encoded by Thra and Thrb, respectively. S …
Thyroid Hormones in Brain Development and Function.
Bernal J. Bernal J. 2025 Sep 29. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. 2025 Sep 29. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 25905404 Free Books & Documents. Review.
Neural cells express the thyroid hormone nuclear receptors THRA and THRB, which mediate most actions of T3, the active hormone. Brain T3 derives in part from the circulation, and in part from type-2 deiodinase-mediated 5'-deiodination of T4 in glial cells and some interneu …
Neural cells express the thyroid hormone nuclear receptors THRA and THRB, which mediate most actions of T3, the active hormone. Brain …
Actions of thyroid hormones and thyromimetics on the liver.
Sinha RA, Bruinstroop E, Yen PM. Sinha RA, et al. Nat Rev Gastroenterol Hepatol. 2025 Jan;22(1):9-22. doi: 10.1038/s41575-024-00991-4. Epub 2024 Oct 17. Nat Rev Gastroenterol Hepatol. 2025. PMID: 39420154 Free PMC article. Review.
Amelioration of hepatic metabolic disease by thyroid hormones in preclinical and clinical studies has spurred the development of thyromimetics that target THRB (the predominant thyroid hormone receptor isoform in the liver) and/or the liver itself to provide more selective activa …
Amelioration of hepatic metabolic disease by thyroid hormones in preclinical and clinical studies has spurred the development of thyromimeti …
THRA and DIO2 mutations are unlikely to be a common cause of increased bone mineral density in euthyroid post-menopausal women.
Gogakos A, Logan JG, Waung JA, Bassett JH, Glüer CC, Reid DM, Felsenberg D, Roux C, Eastell R, Williams GR. Gogakos A, et al. Eur J Endocrinol. 2014 Mar 13;170(4):637-44. doi: 10.1530/EJE-13-1009. Print 2014 Apr. Eur J Endocrinol. 2014. PMID: 24480136
No individuals with DIO2 mutations have been described and the adult phenotype of patients with THRA mutations is largely unknown. We hypothesised that screening euthyroid adults with high bone mineral density (BMD) could be used to identify individuals with mutations of …
No individuals with DIO2 mutations have been described and the adult phenotype of patients with THRA mutations is largely unknown. We …
T3 Promotes Glioma Cell Senescence and Apoptosis via THRA and THRB.
Zhang X, Ma W, Li J, Li C, Liu W, Tang Z, Li L. Zhang X, et al. J Environ Pathol Toxicol Oncol. 2021;40(4):1-9. doi: 10.1615/JEnvironPatholToxicolOncol.2021038740. J Environ Pathol Toxicol Oncol. 2021. PMID: 34936295
Flow cytometry analysis was used to detect cell apoptosis and cell cycle. Thyroid hormone receptor alpha (THRA) and thyroid hormone receptor beta (THRB) were silenced by transfecting si-THRA and si-THRB plasmids into HS683 and A172 glioma cells. ...Cell apoptosis wa …
Flow cytometry analysis was used to detect cell apoptosis and cell cycle. Thyroid hormone receptor alpha (THRA) and thyroid hormone r …
437 results