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Tm7sf2 gene promotes adipocyte differentiation of mouse embryonic fibroblasts and improves insulin sensitivity.
Gatticchi L, Petricciuolo M, Scarpelli P, Macchioni L, Corazzi L, Roberti R. Gatticchi L, et al. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118897. doi: 10.1016/j.bbamcr.2020.118897. Epub 2020 Oct 26. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33121932 Free article.
We investigated the differentiation of Tm7sf2(-/-) MEFs into adipocytes, compared to Tm7sf2(+/+) MEFs. Tm7sf2 expression was increased at late stage of differentiation in wild type cells, while Tm7sf2(-/-) MEFs exhibited a reduced capacity to different …
We investigated the differentiation of Tm7sf2(-/-) MEFs into adipocytes, compared to Tm7sf2(+/+) MEFs. Tm7sf2 expressio …
TM7SF2-induced lipid reprogramming promotes cell proliferation and migration via CPT1A/Wnt/beta-Catenin axis in cervical cancer cells.
Liu H, Liu Y, Zhou Y, Chen X, Pan S, Zhou Q, Ji H, Zhu X. Liu H, et al. Cell Death Discov. 2024 May 1;10(1):207. doi: 10.1038/s41420-024-01975-8. Cell Death Discov. 2024. PMID: 38693136 Free PMC article.
However, the mechanistic basis of TM7SF2 promoting cervical cancer progression via lipid metabolism remains poorly understood. ...While knockout of TM7SF2 obviously attenuated this process. Moreover, TM7SF2 directly bonded with CPT1A, a key enzyme in fatty ac …
However, the mechanistic basis of TM7SF2 promoting cervical cancer progression via lipid metabolism remains poorly understood. ...Whi …
TM7SF2 regulates cell proliferation and apoptosis by activation of C-Raf/ERK pathway in cervical cancer.
Xu Y, Chen X, Pan S, Wang ZW, Zhu X. Xu Y, et al. Cell Death Discov. 2021 Oct 19;7(1):299. doi: 10.1038/s41420-021-00689-5. Cell Death Discov. 2021. PMID: 34667152 Free PMC article.
Moreover, TM7SF2 overexpression contributed to enhancement of xenograft tumor growth in vivo. Our findings indicated that TM7SF2 plays a vital role in tumor promotion by involving in C-Raf/ERK activation. Therefore, TM7SF2 could serve as a therapeutic target …
Moreover, TM7SF2 overexpression contributed to enhancement of xenograft tumor growth in vivo. Our findings indicated that TM7SF2 …
The potential role and mechanism of circRNA/miRNA axis in cholesterol synthesis.
Chen W, Xu J, Wu Y, Liang B, Yan M, Sun C, Wang D, Hu X, Liu L, Hu W, Shao Y, Xing D. Chen W, et al. Int J Biol Sci. 2023 May 29;19(9):2879-2896. doi: 10.7150/ijbs.84994. eCollection 2023. Int J Biol Sci. 2023. PMID: 37324939 Free PMC article. Review.
Many genes play a central role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK, MVD, FDPS, CYP51, TM7SF2, LBR, MSMO1, NSDHL, HSD17B7, DHCR24, EBP, SC5D, DHCR7, IDI1/2. Especially, HMGCR, SQLE, FDFT1, LSS, FDPS, CYP51, and EBP are promising the …
Many genes play a central role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK, MVD, FDPS, CYP51, TM7SF2 …
Tm7sf2 may participate in the healing of burn wounds.
Lei N, Wang P, Meng Q. Lei N, et al. Mol Med Rep. 2016 Jul;14(1):1002-6. doi: 10.3892/mmr.2016.5310. Epub 2016 May 19. Mol Med Rep. 2016. PMID: 27220550
To investigate the importance of Tm7sf2 in the burn wound healing process, a total of 10 Sprague-Dawley rats underwent electrical burns. ...Additionally, the expression levels of Beclin1 and LC3-II were increased, and the addition of siTm7sf2 had a similar effect as the bu …
To investigate the importance of Tm7sf2 in the burn wound healing process, a total of 10 Sprague-Dawley rats underwent electrical bur …
Tm7sf2 Disruption Alters Radial Gene Positioning in Mouse Liver Leading to Metabolic Defects and Diabetes Characteristics.
Gatticchi L, de Las Heras JI, Sivakumar A, Zuleger N, Roberti R, Schirmer EC. Gatticchi L, et al. Front Cell Dev Biol. 2020 Nov 23;8:592573. doi: 10.3389/fcell.2020.592573. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33330474 Free PMC article.
Dam-LaminB1 global profiling in primary liver cells shows that nearly all the genes under such positional regulation are related to/important for liver function. Interestingly, Tm7sf2 is a paralog of the HP1-binding nuclear membrane protein LBR that, like Tm7sf2, al …
Dam-LaminB1 global profiling in primary liver cells shows that nearly all the genes under such positional regulation are related to/importan …
The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury.
Gatticchi L, Bellezza I, Del Sordo R, Peirce MJ, Sidoni A, Roberti R, Minelli A. Gatticchi L, et al. PLoS One. 2015 Nov 5;10(11):e0141885. doi: 10.1371/journal.pone.0141885. eCollection 2015. PLoS One. 2015. PMID: 26540160 Free PMC article.
NF-kappaB activation and TNFalpha up-regulation. Here, by using Tm7sf2+/+and Tm7sf2-/- mice, we investigated whether the Tm7sf2 gene, through its role in cholesterol biosynthesis under stress conditions, is involved in the renal failure induced by the adminis …
NF-kappaB activation and TNFalpha up-regulation. Here, by using Tm7sf2+/+and Tm7sf2-/- mice, we investigated whether the Tm …
A novel role for Tm7sf2 gene in regulating TNFalpha expression.
Bellezza I, Roberti R, Gatticchi L, Del Sordo R, Rambotti MG, Marchetti MC, Sidoni A, Minelli A. Bellezza I, et al. PLoS One. 2013 Jul 23;8(7):e68017. doi: 10.1371/journal.pone.0068017. Print 2013. PLoS One. 2013. PMID: 23935851 Free PMC article.
We used mouse embryonic fibroblasts, derived from Tm7sf2(+/+) and Tm7sf2(-/-) mice, to determine the in vitro effects of thapsigargin on NF-kappaB activation. ...Our data also show that Tm7sf2 gene regulates liver X receptor activation and its absence inhibit …
We used mouse embryonic fibroblasts, derived from Tm7sf2(+/+) and Tm7sf2(-/-) mice, to determine the in vitro effects of thaps …
Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP.
Allimuthu D, Hubler Z, Najm FJ, Tang H, Bederman I, Seibel W, Tesar PJ, Adams DJ. Allimuthu D, et al. Cell Chem Biol. 2019 Apr 18;26(4):593-599.e4. doi: 10.1016/j.chembiol.2019.01.004. Epub 2019 Feb 14. Cell Chem Biol. 2019. PMID: 30773481 Free PMC article.
Identification of the cellular targets of these validated hits revealed a majority inhibited the cholesterol biosynthesis enzymes CYP51, TM7SF2, or EBP. In addition, evaluation of analogs led to identification of CW3388, a potent EBP-inhibiting enhancer of oligodendrocyte …
Identification of the cellular targets of these validated hits revealed a majority inhibited the cholesterol biosynthesis enzymes CYP51, …
Single-cell and genome-wide Mendelian randomization identifies causative genes for gout.
Yang Y, Hu P, Zhang Q, Ma B, Chen J, Wang B, Ma J, Liu D, Hao J, Zhou X. Yang Y, et al. Arthritis Res Ther. 2024 Jun 3;26(1):114. doi: 10.1186/s13075-024-03348-z. Arthritis Res Ther. 2024. PMID: 38831441 Free PMC article.
The study also found that genes such as TRIM46, MAP3K11, KRTCAP2, and TM7SF2 could potentially elevate the risk of gout. Through a Mendelian randomization (MR) analysis, we identified three proteins causally associated with gout: ADH1B, BMP1, and HIST1H3A. ...
The study also found that genes such as TRIM46, MAP3K11, KRTCAP2, and TM7SF2 could potentially elevate the risk of gout. Through a Me …
46 results