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Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum.
Kawai T, Narita H, Konno K, Akter S, Andriani RT, Iwasaki H, Nishikawa S, Yokoi N, Fukata Y, Fukata M, Wiriyasermkul P, Kongpracha P, Nagamori S, Takao K, Miyakawa T, Abe M, Sakimura K, Watanabe M, Nakagawa A, Okamura Y. Kawai T, et al. Biochem J. 2022 Jun 17;479(11):1127-1145. doi: 10.1042/BCJ20220033. Biochem J. 2022. PMID: 35574701
Here, we approached the molecular function of TMEM266 by performing co-immunoprecipitation experiments. We unexpectedly discovered that TMEM266 proteins natively interact with the novel short form splice variants that only have voltage-sensor domains and putative cy …
Here, we approached the molecular function of TMEM266 by performing co-immunoprecipitation experiments. We unexpectedly discovered th …
Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids.
Hua T, Liu C, Kiran S, Gray K, Jung S, Meckes DG Jr, Li Y, Sang QA. Hua T, et al. Sci Rep. 2022 Jul 27;12(1):12880. doi: 10.1038/s41598-022-16970-1. Sci Rep. 2022. PMID: 35896708 Free PMC article.
However, the expression of cerebellar genes for the molecular layer (BHLE22), the granule cell layer (GABRB2, PAX6, TMEM266, KCNIP4), the Bergmann glial cells (QK1, DAO), and the Purkinje cell layer (ARHGEF33, KIT, MX1, MYH10, PPP1R17, SCGN) was significantly higher in the …
However, the expression of cerebellar genes for the molecular layer (BHLE22), the granule cell layer (GABRB2, PAX6, TMEM266, KCNIP4), …
Genome-wide associations with longevity and reproductive traits in U.S. rangeland ewes.
Smitchger JA, Taylor JB, Mousel MR, Schaub D, Thorne JW, Becker GM, Murdoch BM. Smitchger JA, et al. Front Genet. 2024 May 27;15:1398123. doi: 10.3389/fgene.2024.1398123. eCollection 2024. Front Genet. 2024. PMID: 38859938 Free PMC article.
These genes include ALPL, ANOS1, ARHGEF26, ASIC2, ASTN2, ATP8A2, CAMK2D, CEP89, DISC1, ITGB6, KCNH8, MBNL3, MINDY4, MTSS1, PLEKHA7, PRIM2, RNF43, ROBO2, SLCO1A2, TMEM266, TNFRSF21, and ZNF804B. Discussion: This study proposes multiple SNPs as candidates for use in selectio …
These genes include ALPL, ANOS1, ARHGEF26, ASIC2, ASTN2, ATP8A2, CAMK2D, CEP89, DISC1, ITGB6, KCNH8, MBNL3, MINDY4, MTSS1, PLEKHA7, PRIM2, R …
Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants.
Everson TM, O'Shea TM, Burt A, Hermetz K, Carter BS, Helderman J, Hofheimer JA, McGowan EC, Neal CR, Pastyrnak SL, Smith LM, Soliman A, DellaGrotta SA, Dansereau LM, Padbury JF, Lester BM, Marsit CJ. Everson TM, et al. Clin Epigenetics. 2020 Oct 19;12(1):151. doi: 10.1186/s13148-020-00942-1. Clin Epigenetics. 2020. PMID: 33076993 Free PMC article.
RESULTS: We identified ten differentially methylated CpGs (alpha Bonferroni-adjusted for 706,278 tests) that were associated with increasing neonatal morbidity risk scores at three intergenic regions and at HPS4, SRRD, FGFR1OP, TNS3, TMEM266, LRRC3B, ZNF780A, and TENM2. Th …
RESULTS: We identified ten differentially methylated CpGs (alpha Bonferroni-adjusted for 706,278 tests) that were associated with increasing …
Oncogenic Roles of Polycomb Repressive Complex 2 in Bladder Cancer and Upper Tract Urothelial Carcinoma.
Huang EY, Chen YK, Ou CP, Chen YT, Chen SF, Huang WJ, Liang KH. Huang EY, et al. Biomedicines. 2022 Nov 14;10(11):2925. doi: 10.3390/biomedicines10112925. Biomedicines. 2022. PMID: 36428492 Free PMC article.
It is also negatively correlated with CNPY2, KB-1208A12, RP11-175B9, ZNF692, RANP8, RP11-245C17, TMEM266, FBXW9, SUGT1P2, and PRH1. In conclusion, PRC2 and its epigenetic effects are major oncogenic mechanisms underlying both bladder cancer and UTUC. ...
It is also negatively correlated with CNPY2, KB-1208A12, RP11-175B9, ZNF692, RANP8, RP11-245C17, TMEM266, FBXW9, SUGT1P2, and PRH1. I …