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TMPRSS11B promotes an acidified microenvironment and immune suppression in squamous lung cancer.
Sunil HS, Clemenceau JR, Grichuk A, Barnfather I, Nakkireddy SR, Izzo L, Feng Q, Hartnett W, Evers BM, Thomas L, Subramaniyan I, Li L, Putnam WC, Hepensteil S, Zhu J, Updegraff B, Minna JD, DeBerardinis RJ, Hwang TH, Gao J, Oliver TG, O'Donnell KA. Sunil HS, et al. EMBO Rep. 2025 Dec;26(24):6346-6379. doi: 10.1038/s44319-025-00631-1. Epub 2025 Nov 10. EMBO Rep. 2025. PMID: 41214366 Free PMC article.
Here, we evaluate the impact of TMPRSS11B activity on the host immune system and the tumor microenvironment (TME). Tmprss11b depletion significantly reduces tumor burden in immunocompetent mice and triggers an infiltration of immune cells. ...These results demonstra …
Here, we evaluate the impact of TMPRSS11B activity on the host immune system and the tumor microenvironment (TME). Tmprss11b d …
Transmembrane Serine Protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in lung squamous cell carcinoma.
Sunil HS, Clemenceau J, Barnfather I, Nakkireddy SR, Grichuk A, Izzo L, Evers BM, Thomas L, Subramaniyan I, Li L, Putnam WT, Zhu J, Updegraff B, Minna JD, DeBerardinis RJ, Gao J, Hwang TH, Oliver TG, O'Donnell KA. Sunil HS, et al. bioRxiv [Preprint]. 2025 Apr 3:2025.04.01.646727. doi: 10.1101/2025.04.01.646727. bioRxiv. 2025. Update in: EMBO Rep. 2025 Dec;26(24):6346-6379. doi: 10.1038/s44319-025-00631-1. PMID: 40235980 Free PMC article. Updated. Preprint.
To determine the impact of TMPRSS11B activity on the host immune system and the tumor microenvironment (TME), we evaluated the effect of Tmprss11b depletion in a syngeneic mouse model. Tmprss11b depletion significantly reduced tumor burden in immunocompetent …
To determine the impact of TMPRSS11B activity on the host immune system and the tumor microenvironment (TME), we evaluated the effect …
Transmembrane Protease Serine 11B Modulates Lactate Transport Through SLC16A1 in Pancreatic Ductal Adenocarcinoma-A Functional Link to Phenotype Heterogeneity.
Baiskhanova D, Menzel M, Geismann C, Röcken C, Beitz E, Sebens S, Trauzold A, Schäfer H. Baiskhanova D, et al. Int J Mol Sci. 2025 Jun 4;26(11):5398. doi: 10.3390/ijms26115398. Int J Mol Sci. 2025. PMID: 40508207 Free PMC article.
Expression and function of both carriers are controlled by the chaperone Basigin (BSG), which itself is functionally controlled by the transmembrane protease serine 11B (TMPRSS11B). In this study we explored the impact of TMPRSS11B on the phenotype of PDAC cells und …
Expression and function of both carriers are controlled by the chaperone Basigin (BSG), which itself is functionally controlled by the trans …
Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism.
Updegraff BL, Zhou X, Guo Y, Padanad MS, Chen PH, Yang C, Sudderth J, Rodriguez-Tirado C, Girard L, Minna JD, Mishra P, DeBerardinis RJ, O'Donnell KA. Updegraff BL, et al. Cell Rep. 2018 Nov 20;25(8):2223-2233.e6. doi: 10.1016/j.celrep.2018.10.100. Cell Rep. 2018. PMID: 30463017 Free PMC article.
TMPRSS11B inhibition in human LSCCs reduces transformation and tumor growth. Given that TMPRSS11B harbors an extracellular (EC) protease domain, we hypothesized that catalysis of a membrane-bound substrate modulates tumor progression. ...Basigin release mediated by …
TMPRSS11B inhibition in human LSCCs reduces transformation and tumor growth. Given that TMPRSS11B harbors an extracellular (EC …
Identification and validation of genes associated with copper death in oral squamous cell carcinoma based on machine learning and weighted gene co-expression network analysis.
Zhang M, Li Q, Zhang W, Yang Y, Gu J, Dong Q. Zhang M, et al. J Stomatol Oral Maxillofac Surg. 2023 Dec;124(6S):101561. doi: 10.1016/j.jormas.2023.101561. Epub 2023 Jul 13. J Stomatol Oral Maxillofac Surg. 2023. PMID: 37451513
The AUC for TMPRSS11B, SERPINH1, and CDH3 in ROC curve analysis were 78.1%, 95.6%, and 87.5%, respectively. CONCLUSION: TMPRSS11B, SERPINH1, and CDH3 may be pivotal for OSCC development and progression and potential targets for new therapeutic and predictive strateg …
The AUC for TMPRSS11B, SERPINH1, and CDH3 in ROC curve analysis were 78.1%, 95.6%, and 87.5%, respectively. CONCLUSION: TMPRSS11B …
Epithelial and immune transcriptomic characteristics and possible regulatory mechanisms in asthma exacerbation: insights from integrated studies.
Liu Y, Li Y, Wu R, Wang Y, Li P, Jiang T, Wang K, Liu Y, Cheng Z. Liu Y, et al. Front Immunol. 2025 Jan 23;16:1512053. doi: 10.3389/fimmu.2025.1512053. eCollection 2025. Front Immunol. 2025. PMID: 39917297 Free PMC article.
Notably, TMPRSS11A, TUBA1A, SCEL, ICAM4, TMPRSS11B, IGFBP2, CLC, NFAM1 and F13A1 were identified as key regulatory genes of asthma. ...
Notably, TMPRSS11A, TUBA1A, SCEL, ICAM4, TMPRSS11B, IGFBP2, CLC, NFAM1 and F13A1 were identified as key regulatory genes of asthma. . …
Identification of the differences in molecular networks between idiopathic pulmonary fibrosis and lung squamous cell carcinoma using machine learning.
Nojima Y, Mizuguchi K. Nojima Y, et al. Comput Biol Chem. 2025 Dec;119:108560. doi: 10.1016/j.compbiolchem.2025.108560. Epub 2025 Jun 19. Comput Biol Chem. 2025. PMID: 40580591 Free article.
Furthermore, we detected somatic mutations affecting gene expression using SCC data. The ML models identified VCX2, TMPRSS11B, PRUNE2, PRG4, PZP, SCARA5, DES, HPSE2, HOXD11, S100A7A, and PLA2G2A as DEGs. ...
Furthermore, we detected somatic mutations affecting gene expression using SCC data. The ML models identified VCX2, TMPRSS11B, PRUNE2 …
COVID-19 and human spermatozoa-Potential risks for infertility and sexual transmission?
Aitken RJ. Aitken RJ. Andrology. 2021 Jan;9(1):48-52. doi: 10.1111/andr.12859. Epub 2020 Aug 5. Andrology. 2021. PMID: 32649023 Free PMC article. Review.
The latter not only provides COVID-19 with a foothold on the sperm surface but may also promote integration, given the additional presence of a range of proteases (TMPRSS2, TMPRSS11B, TMPRSS12, furin) capable of promoting viral fusion. This article reviews the roles played …
The latter not only provides COVID-19 with a foothold on the sperm surface but may also promote integration, given the additional presence o …
Identification of key miRNA-gene pairs in gastric cancer through integrated analysis of mRNA and miRNA microarray.
Zhu T, Lou Q, Shi Z, Chen G. Zhu T, et al. Am J Transl Res. 2021 Jan 15;13(1):253-269. eCollection 2021. Am J Transl Res. 2021. PMID: 33527022 Free PMC article.
In the regulatory network, the top 5 up-regulated genes were Transmembrane Protease, Serine 11B (TMPRSS11B), regulator of G protein signaling 1 (RGS1), cysteine rich angiogenic inducer 61 (CYR61), inhibin subunit beta A (INHBA), syntrophin gamma 1 (SNTG1), and the top 5 do …
In the regulatory network, the top 5 up-regulated genes were Transmembrane Protease, Serine 11B (TMPRSS11B), regulator of G protein s …
A comprehensive transcriptome based meta-analysis to unveil the aggression nexus of oral squamous cell carcinoma.
Vastrad SJ, Saraswathy GR, Dasari JB, Nair G, Madarakhandi A, Augustine D, Sowmya SV. Vastrad SJ, et al. Biochem Biophys Rep. 2025 Apr 7;42:102001. doi: 10.1016/j.bbrep.2025.102001. eCollection 2025 Jun. Biochem Biophys Rep. 2025. PMID: 40271514 Free PMC article.
The highest-ranked gene, MMP1, showed a log-fold change (LFC) of 4.946 (95 % CI: 3.71, 6.18) in nodal-negative samples, which increased to 5.899 (95 % CI: 4.80, 6.99) in nodal-positive samples, indicating consistent elevation across disease stages. In contrast, TMPRSS11B w …
The highest-ranked gene, MMP1, showed a log-fold change (LFC) of 4.946 (95 % CI: 3.71, 6.18) in nodal-negative samples, which increased to 5 …
11 results