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Year Number of Results
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Page 1
TNKS1BP1 facilitates ubiquitination of CNOT4 by TRIM21 to promote hepatocellular carcinoma progression and immune evasion.
Wang Y, Sandrine IK, Ma L, Chen K, Chen X, Yu Y, Wang S, Xiao L, Li C, Liu Y, Liu B, Yuan X. Wang Y, et al. Cell Death Dis. 2024 Jul 17;15(7):511. doi: 10.1038/s41419-024-06897-y. Cell Death Dis. 2024. PMID: 39019859 Free PMC article.
Autophagy and lipid reprogramming were identified as two possible mechanisms underlying the pro-tumor effect of TNKS1BP1. Upregulated TNKS1BP1 inhibited autophagy while induced lipid accumulation by inhibiting the JAK2/STAT3 pathway upon the degradation of CNOT4 in …
Autophagy and lipid reprogramming were identified as two possible mechanisms underlying the pro-tumor effect of TNKS1BP1. Upregulated …
TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation.
Zhu J, Ao X, Liu Y, Zhou S, Hou Y, Yan Z, Zhou L, Chen H, Wang P, Liang X, Xie D, Gao S, Zhou PK, Gu Y. Zhu J, et al. Respir Res. 2024 Aug 7;25(1):299. doi: 10.1186/s12931-024-02914-y. Respir Res. 2024. PMID: 39113018 Free PMC article.
Using a model system of TNKS1BP1 knockout (KO) mice, we demonstrated that TNKS1BP1 KO prevents IR-induced lung tissue senescence and RILI. CONCLUSIONS: Notably, this study suggested that a regulatory mechanism of the TNKS1BP1/CNOT4/EEF2 axis in AECII senescen …
Using a model system of TNKS1BP1 knockout (KO) mice, we demonstrated that TNKS1BP1 KO prevents IR-induced lung tissue senescen …
Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion.
Ohishi T, Yoshida H, Katori M, Migita T, Muramatsu Y, Miyake M, Ishikawa Y, Saiura A, Iemura SI, Natsume T, Seimiya H. Ohishi T, et al. Cancer Res. 2017 May 1;77(9):2328-2338. doi: 10.1158/0008-5472.CAN-16-1846. Epub 2017 Feb 15. Cancer Res. 2017. PMID: 28202517
TNKS1BP1 colocalized with actin filaments and negatively regulated cell invasion. In TNKS1BP1-depleted cells, actin filament dynamics, focal adhesion, and lamellipodia ruffling were increased with activation of the ROCK/LIMK/cofilin pathway. TNKS1BP1 bound th …
TNKS1BP1 colocalized with actin filaments and negatively regulated cell invasion. In TNKS1BP1-depleted cells, actin filament d …
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1.
Zou LH, Shang ZF, Tan W, Liu XD, Xu QZ, Song M, Wang Y, Guan H, Zhang SM, Yu L, Zhong CG, Zhou PK. Zou LH, et al. Oncotarget. 2015 Mar 30;6(9):7011-22. doi: 10.18632/oncotarget.3137. Oncotarget. 2015. PMID: 25749521 Free PMC article.
Here we firstly identified that TNKS1BP1 was up-regulated by ionizing radiation (IR) and the depletion of TNKS1BP1 significantly sensitized cancer cells to IR. ...Moreover, TNKS1BP1 was shown to promote the association of PARP-1 and DNA-PKcs. Overexpression o …
Here we firstly identified that TNKS1BP1 was up-regulated by ionizing radiation (IR) and the depletion of TNKS1BP1 significant …
Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks.
Tan W, Guan H, Zou LH, Wang Y, Liu XD, Rang WQ, Zhou PK, Pei HD, Zhong CG. Tan W, et al. Cancer Med. 2017 Feb;6(2):483-493. doi: 10.1002/cam4.995. Epub 2017 Jan 6. Cancer Med. 2017. PMID: 28058814 Free PMC article.
TNKS1BP1 is a member of the poly(ADP-ribose) polymerase (PARP) superfamily. Our previous studies have demonstrated that TNKS1BP1 plays an important role in DNA damage response. ...Overall, our study indicates that, in LAC, aberrant expressions of TNKS1BP1 are …
TNKS1BP1 is a member of the poly(ADP-ribose) polymerase (PARP) superfamily. Our previous studies have demonstrated that TNKS1BP1 …
TCF3-activated FAM201A enhances cell proliferation and invasion via miR-186-5p/TNKS1BP1 axis in triple-negative breast cancer.
Jia H, Wu D, Zhang Z, Li S. Jia H, et al. Bioorg Chem. 2020 Nov;104:104301. doi: 10.1016/j.bioorg.2020.104301. Epub 2020 Sep 22. Bioorg Chem. 2020. PMID: 33011533
The interaction among FAM201A, microRNA-186-5p (miR-186-5p), and tankyrase 1 binding protein 1 (TNKS1BP1) was evaluated by luciferase reporter and RIP assays. The results showed that FAM201A expression was significantly upregulated in TNBC tissues and cells. ...In mechanis …
The interaction among FAM201A, microRNA-186-5p (miR-186-5p), and tankyrase 1 binding protein 1 (TNKS1BP1) was evaluated by luciferase …
Endothelial p130cas confers resistance to anti-angiogenesis therapy.
Wen Y, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J, Hung MC, Sood AK. Wen Y, et al. Cell Rep. 2022 Jan 25;38(4):110301. doi: 10.1016/j.celrep.2022.110301. Cell Rep. 2022. PMID: 35081345 Free PMC article.
Nuclear VEGFR2 and p130cas fragments, together with TNKS1BP1 (tankyrase-1-binding protein), initiate endothelial cell death. Blockade of autophagy in AVA-resistant endothelial cells retains VEGFR2 at the membrane with bevacizumab treatment. ...
Nuclear VEGFR2 and p130cas fragments, together with TNKS1BP1 (tankyrase-1-binding protein), initiate endothelial cell death. Blockade …
Ocular Mucous Membrane Pemphigoid Demonstrates a Distinct Autoantibody Profile from Those of Other Autoimmune Blistering Diseases: A Preliminary Study.
Liu Y, Bao L, Sodha D, Li J, Mansini A, Djalilian AR, Li X, Qian H, Ishii N, Hashimoto T, Amber KT. Liu Y, et al. Antibodies (Basel). 2024 Nov 14;13(4):91. doi: 10.3390/antib13040091. Antibodies (Basel). 2024. PMID: 39584991 Free PMC article.
Several protein hits identified in our study demonstrated enriched expression on the anterior surface epithelia, including TNKS1BP1, SEC16B, FNBP4, CASZ1, GOLGB1, DOT1L, PRDM 15, LARP4B, and RPL6. Likewise, a previous study of mouse knockout models of murine analogs CASZ1, …
Several protein hits identified in our study demonstrated enriched expression on the anterior surface epithelia, including TNKS1BP1, …
26 results