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How is alpha-synuclein cleared from the cell?

Stefanis L, Emmanouilidou E, Pantazopoulou M, Kirik D, Vekrellis K, Tofaris GK. Stefanis L, et al. Among authors: tofaris gk. J Neurochem. 2019 Sep;150(5):577-590. doi: 10.1111/jnc.14704. Epub 2019 May 8. J Neurochem. 2019. PMID: 31069800 Free article. Review.

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Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism.

Jiang C, Hopfner F, Katsikoudi A, Hein R, Catli C, Evetts S, Huang Y, Wang H, Ryder JW, Kuhlenbaeumer G, Deuschl G, Padovani A, Berg D, Borroni B, Hu MT, Davis JJ, Tofaris GK. Jiang C, et al. Among authors: tofaris gk. J Neurol Neurosurg Psychiatry. 2020 Jul;91(7):720-729. doi: 10.1136/jnnp-2019-322588. Epub 2020 Apr 9. J Neurol Neurosurg Psychiatry. 2020. PMID: 32273329 Free PMC article.

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Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes.

Jiang C, Hopfner F, Berg D, Hu MT, Pilotto A, Borroni B, Davis JJ, Tofaris GK. Jiang C, et al. Among authors: tofaris gk. Mov Disord. 2021 Nov;36(11):2663-2669. doi: 10.1002/mds.28591. Epub 2021 Apr 7. Mov Disord. 2021. PMID: 33826157 Free PMC article.

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Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.

Tanudjojo B, Shaikh SS, Fenyi A, Bousset L, Agarwal D, Marsh J, Zois C, Heman-Ackah S, Fischer R, Sims D, Melki R, Tofaris GK. Tanudjojo B, et al. Among authors: tofaris gk. Nat Commun. 2021 Jun 21;12(1):3817. doi: 10.1038/s41467-021-23682-z. Nat Commun. 2021. PMID: 34155194 Free PMC article.

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Multiplexed Profiling of Extracellular Vesicles for Biomarker Development.

Jiang C, Fu Y, Liu G, Shu B, Davis J, Tofaris GK. Jiang C, et al. Among authors: tofaris gk. Nanomicro Lett. 2021 Dec 2;14(1):3. doi: 10.1007/s40820-021-00753-w. Nanomicro Lett. 2021. PMID: 34855021 Free PMC article. Review.

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Convergent molecular defects underpin diverse neurodegenerative diseases.

Tofaris GK, Buckley NJ. Tofaris GK, et al. J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):962-969. doi: 10.1136/jnnp-2017-316988. Epub 2018 Feb 19. J Neurol Neurosurg Psychiatry. 2018. PMID: 29459380 Review.

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The Transcellular Propagation and Intracellular Trafficking of α-Synuclein.

Tofaris GK, Goedert M, Spillantini MG. Tofaris GK, et al. Cold Spring Harb Perspect Med. 2017 Sep 1;7(9):a024380. doi: 10.1101/cshperspect.a024380. Cold Spring Harb Perspect Med. 2017. PMID: 27920026 Free PMC article. Review.

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The endosomal pathway in Parkinson's disease.

Perrett RM, Alexopoulou Z, Tofaris GK. Perrett RM, et al. Among authors: tofaris gk. Mol Cell Neurosci. 2015 May;66(Pt A):21-8. doi: 10.1016/j.mcn.2015.02.009. Epub 2015 Feb 19. Mol Cell Neurosci. 2015. PMID: 25701813 Review.

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Monitoring α-Synuclein Proteotoxicity in Drosophila Models.

Szabo A, Tofaris GK. Szabo A, et al. Among authors: tofaris gk. Methods Mol Biol. 2019;1948:199-208. doi: 10.1007/978-1-4939-9124-2_15. Methods Mol Biol. 2019. PMID: 30771179

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Physiological and pathological properties of alpha-synuclein.

Tofaris GK, Spillantini MG. Tofaris GK, et al. Cell Mol Life Sci. 2007 Sep;64(17):2194-201. doi: 10.1007/s00018-007-7217-5. Cell Mol Life Sci. 2007. PMID: 17605001 Review.

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