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Impaired blood-brain barrier in the microbiota-gut-brain axis: Potential role of bipolar susceptibility gene TRANK1.
Lai J, Jiang J, Zhang P, Xi C, Wu L, Gao X, Fu Y, Zhang D, Chen Y, Huang H, Zhu Y, Hu S. Lai J, et al. J Cell Mol Med. 2021 Jul;25(14):6463-6469. doi: 10.1111/jcmm.16611. Epub 2021 May 20. J Cell Mol Med. 2021. PMID: 34014031 Free PMC article. Review.
Administration of type 1 interferon can induce the expression of TRANK1, which is associated with elevated circulating biomarkers of the impaired blood-brain barrier in BD patients. In this review, we focus on the influence of intestine microbiota on the expression of bipo …
Administration of type 1 interferon can induce the expression of TRANK1, which is associated with elevated circulating biomarkers of …
Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.
Li W, Cai X, Li HJ, Song M, Zhang CY, Yang Y, Zhang L, Zhao L, Liu W, Wang L, Shao M, Zhang Y, Zhang C, Cai J, Zhou DS, Li X, Hui L, Jia QF, Qu N, Zhong BL, Zhang SF, Chen J, Xia B, Li Y, Song X, Fan W, Tang W, Tang W, Tang J, Chen X, Yue W, Zhang D, Fang Y, Xiao X, Li M, Lv L, Chang H. Li W, et al. Neuropsychopharmacology. 2021 May;46(6):1103-1112. doi: 10.1038/s41386-020-00788-4. Epub 2020 Aug 13. Neuropsychopharmacology. 2021. PMID: 32791513 Free PMC article.
We also identified another SNP rs4789 in the 3' untranslated region (3'UTR) of TRANK1 showing stronger eQTL associations as well as genome-wide significant association with BD. ...Overall, our results support that TRANK1 is a potential BD risk gene. Further studies …
We also identified another SNP rs4789 in the 3' untranslated region (3'UTR) of TRANK1 showing stronger eQTL associations as well as g …
Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness.
Jiang X, Detera-Wadleigh SD, Akula N, Mallon BS, Hou L, Xiao T, Felsenfeld G, Gu X, McMahon FJ. Jiang X, et al. Mol Psychiatry. 2019 Apr;24(4):613-624. doi: 10.1038/s41380-018-0207-1. Epub 2018 Aug 22. Mol Psychiatry. 2019. PMID: 30135510 Free PMC article.
IPSC-derived neural progenitor cells carrying the risk allele of the single nucleotide polymorphism (SNP), rs9834970, displayed lower baseline TRANK1 expression that was rescued by chronic treatment with therapeutic dosages of valproic acid (VPA). ...Decreased expression o …
IPSC-derived neural progenitor cells carrying the risk allele of the single nucleotide polymorphism (SNP), rs9834970, displayed lower baseli …
New Evidence of Gut Microbiota Involvement in the Neuropathogenesis of Bipolar Depression by TRANK1 Modulation: Joint Clinical and Animal Data.
Lai J, Zhang P, Jiang J, Mou T, Li Y, Xi C, Wu L, Gao X, Zhang D, Chen Y, Huang H, Li H, Cai X, Li M, Zheng P, Hu S. Lai J, et al. Front Immunol. 2021 Dec 21;12:789647. doi: 10.3389/fimmu.2021.789647. eCollection 2021. Front Immunol. 2021. PMID: 34992606 Free PMC article.
Tetratricopeptide repeat and ankyrin repeat containing 1 (TRANK1) is a robust risk gene of bipolar disorder (BD). However, little is known on the role of TRANK1 in the pathogenesis of BD and whether the gut microbiota is capable of regulating TRANK1 expressio …
Tetratricopeptide repeat and ankyrin repeat containing 1 (TRANK1) is a robust risk gene of bipolar disorder (BD). However, little is …
Fine-mapping genomic loci refines bipolar disorder risk genes.
Koromina M, Ravi A, Panagiotaropoulou G, Schilder BM, Humphrey J, Braun A, Bidgeli T, Chatzinakos C, Coombes BJ, Kim J, Liu X, Terao C, O'Connell KS, Adams MJ, Adolfsson R, Alda M, Alfredsson L, Andlauer TFM, Andreassen OA, Antoniou A, Baune BT, Bengesser S, Biernacka J, Boehnke M, Bosch R, Cairns MJ, Carr VJ, Casas M, Catts S, Cichon S, Corvin A, Craddock N, Dafnas K, Dalkner N, Dannlowski U, Degenhardt F, Di Florio A, Dikeos D, Fellendorf FT, Ferentinos P, Forstner AJ, Forty L, Frye M, Fullerton JM, Gawlik M, Gizer IR, Gordon-Smith K, Green MJ, Grigoroiu-Serbanescu M, Guzman-Parra J, Hahn T, Henskens F, Hillert J, Jablensky AV, Jones L, Jones I, Jonsson L, Kelsoe JR, Kircher T, Kirov G, Kittel-Schneider S, Kogevinas M, Landén M, Leboyer M, Lenger M, Lissowska J, Lochner C, Loughland C, MacIntyre DJ, Martin NG, Maratou E, Mathews CA, Mayoral F, McElroy SL, McGregor NW, McIntosh A, McQuillin A, Michie P, Mitchell PB, Moutsatsou P, Mowry B, Müller-Myhsok B, Myers RM, Nenadić I, Nievergelt CM, Nöthen MM, Nurnberger J, 'Donovan MO, 'Donovan CO, Ophoff RA, Owen MJ, Pantelis C, Pato C, Pato MT, Patrinos GP, Pawlak JM, Perlis RH, Porichi E, Posthuma D, Ramos-Quiroga JA, Reif A, Reiningh… See abstract for full author list ➔ Koromina M, et al. Nat Neurosci. 2025 Jul;28(7):1393-1403. doi: 10.1038/s41593-025-01998-z. Epub 2025 Jun 25. Nat Neurosci. 2025. PMID: 40562893 Free PMC article.
Convergent lines of evidence supported the roles of genes involved in neurotransmission and neurodevelopment, including SCN2A, TRANK1, DCLK3, INSYN2B, SYNE1, THSD7A, CACNA1B, TUBBP5, FKBP2, RASGRP1, FURIN, FES, MED24 and THRA among others in bipolar disorder. ...
Convergent lines of evidence supported the roles of genes involved in neurotransmission and neurodevelopment, including SCN2A, TRANK1 …
Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.
Ambati A, Hillary R, Leu-Semenescu S, Ollila HM, Lin L, During EH, Farber N, Rico TJ, Faraco J, Leary E, Goldstein-Piekarski AN, Huang YS, Han F, Sivan Y, Lecendreux M, Dodet P, Honda M, Gadoth N, Nevsimalova S, Pizza F, Kanbayashi T, Peraita-Adrados R, Leschziner GD, Hasan R, Canellas F, Kume K, Daniilidou M, Bourgin P, Rye D, Vicario JL, Hogl B, Hong SC, Plazzi G, Mayer G, Landtblom AM, Dauvilliers Y, Arnulf I, Mignot EJ. Ambati A, et al. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2005753118. doi: 10.1073/pnas.2005753118. Proc Natl Acad Sci U S A. 2021. PMID: 33737391 Free PMC article.
We found a strong genome-wide significant association (rs71947865, Odds Ratio [OR] = 1.48, P = 8.6 10(-9)) within the 3'region of TRANK1 gene locus, previously associated with bipolar disorder and schizophrenia. Strikingly, KLS cases with rs71947865 variant had significant …
We found a strong genome-wide significant association (rs71947865, Odds Ratio [OR] = 1.48, P = 8.6 10(-9)) within the 3'region of TRANK1 …
Sleep Disorder Kleine-Levin Syndrome (KLS) Joins the List of Polygenic Brain Disorders Associated with Obstetric Complications.
Hamper M, Schmidt-Kastner R. Hamper M, et al. Cell Mol Neurobiol. 2023 Oct;43(7):3393-3403. doi: 10.1007/s10571-023-01391-z. Epub 2023 Aug 9. Cell Mol Neurobiol. 2023. PMID: 37553546 Free PMC article. Review.
Recent studies have focused on genetic factors whereby the first genome-wide association study (GWAS) in Kleine-Levin Syndrome has defined a linkage at the TRANK1 locus. A Gene x Environment interaction model involving obstetric complications was proposed based on concepts …
Recent studies have focused on genetic factors whereby the first genome-wide association study (GWAS) in Kleine-Levin Syndrome has defined a …
An Update on Kleine-Levin Syndrome.
Qasrawi SO, BaHammam AS. Qasrawi SO, et al. Curr Sleep Med Rep. 2023;9(1):35-44. doi: 10.1007/s40675-022-00246-1. Epub 2022 Dec 27. Curr Sleep Med Rep. 2023. PMID: 36590182 Free PMC article. Review.
RECENT FINDINGS: Genetic links were reported in some patients with KLS, like variation in TRANK1 in a worldwide case-control genome-wide association in patients with KLS, in addition to several uncommon variations in the LMOD3 gene, some of which are likely to be pathogeni …
RECENT FINDINGS: Genetic links were reported in some patients with KLS, like variation in TRANK1 in a worldwide case-control genome-w …
Fine-mapping genomic loci refines bipolar disorder risk genes.
Koromina M, Ravi A, Panagiotaropoulou G, Schilder BM, Humphrey J, Braun A, Bidgeli T, Chatzinakos C, Coombes B, Kim J, Liu X, Terao C, O 'Connell KS, Adams M, Rolf A, Alda M, Alfredsson L, Andlauer TFM, Andreassen OA, Antoniou A, Baune BT, Bengesser S, Biernacka J, Boehnke M, Bosch R, Cairns MJ, Carr VJ, Casas M, Catts S, Cichon S, Corvin A, Craddock N, Dafnas K, Dalkner N, Dannlowski U, Degenhardt F, Florio AD, Dikeos D, Fellendorf FT, Ferentinos P, Forstner AJ, Forty L, Frye M, Fullerton JM, Gawlik M, Gizer IR, Gordon-Smith K, Green MJ, Grigoroiu-Serbanescu M, Guzman-Parra J, Hahn T, Henskens F, Hillert J, Jablensky AV, Jones L, Jones I, Jonsson L, Kelsoe JR, Kircher T, Kirov G, Kittel-Schneider S, Kogevinas M, Landén M, Leboyer M, Lenger M, Lissowska J, Lochner C, Loughland C, MacIntyre D, Martin NG, Maratou E, Mathews CA, Mayoral F, McElroy SL, McGregor NW, McIntosh A, McQuillin A, Michie P, Mitchell PB, Moutsatsou P, Mowry B, Müller-Myhsok B, Myers RM, Nenadić I, Nievergelt C, Nöthen MM, Nurnberger J, O 'Donovan M, O'Donovan C, Ophoff RA, Owen MJ, Pantelis C, Pato C, Pato MT, Patrinos GP, Pawlak JM, Perlis RH, Porichi E, Posthuma D, Ramos-Quiroga JA, Reif A, Reininghaus EZ, R… See abstract for full author list ➔ Koromina M, et al. medRxiv [Preprint]. 2024 Sep 17:2024.02.12.24302716. doi: 10.1101/2024.02.12.24302716. medRxiv. 2024. Update in: Nat Neurosci. 2025 Jul;28(7):1393-1403. doi: 10.1038/s41593-025-01998-z. PMID: 38405768 Free PMC article. Updated. Preprint.
Convergent lines of evidence supported the roles of genes involved in neurotransmission and neurodevelopment including SCN2A, TRANK1, DCLK3, INSYN2B, SYNE1, THSD7A, CACNA1B, TUBBP5, PLCB3, PRDX5, KCNK4, CRTC3, AP001453.3, TRPT1, FKBP2, DNAJC4, RASGRP1, FURIN, FES, DPH1, GS …
Convergent lines of evidence supported the roles of genes involved in neurotransmission and neurodevelopment including SCN2A, TRANK1, …
34 results