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TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice.
Tresky R, Miyamoto Y, Nagayoshi Y, Yabuki Y, Araki K, Takahashi Y, Komohara Y, Ge H, Nishiguchi K, Fukuda T, Kaneko H, Maeda N, Matsuura J, Iwasaki S, Sakakida K, Shioda N, Wei FY, Tomizawa K, Chujo T. Tresky R, et al. Nucleic Acids Res. 2024 Aug 27;52(15):9230-9246. doi: 10.1093/nar/gkae520. Nucleic Acids Res. 2024. PMID: 38950903 Free PMC article.
Pathogenic mutations in TRMT10A cause intellectual disability, microcephaly, diabetes, and short stature in humans, and generate cytotoxic tRNA fragments in cultured cells; however, it is not clear how TRMT10A supports codon translation or brain functions. Here, we …
Pathogenic mutations in TRMT10A cause intellectual disability, microcephaly, diabetes, and short stature in humans, and generate cyto …
New Insights Into TRMT10A Syndrome: Case Report and Literature Review.
Ceraolo G, Spoto G, Butera A, Spanò M, Vinci M, Vitello GA, Musumeci A, Calì F, Nicotera AG, Di Rosa G. Ceraolo G, et al. Am J Med Genet B Neuropsychiatr Genet. 2025 Apr;198(3):e33015. doi: 10.1002/ajmg.b.33015. Epub 2024 Oct 23. Am J Med Genet B Neuropsychiatr Genet. 2025. PMID: 39440920 Review.
TRMT10A is related to a syndrome characterized by early-onset diabetes mellitus, microcephaly, epilepsy, and intellectual disability. ...The prominent neurological involvement of our patient enhances the implication of TRMT10A in the brain development, suggesting a …
TRMT10A is related to a syndrome characterized by early-onset diabetes mellitus, microcephaly, epilepsy, and intellectual disability. …
Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer.
Yang Y, Liu Q, Li X, Zhang H, Xu X, Ma Q, Nowsheen S, Aziz K, Li YX, Lou Z, Zhong Q, Deng M. Yang Y, et al. Sci Adv. 2025 Oct 10;11(41):eadw7989. doi: 10.1126/sciadv.adw7989. Epub 2025 Oct 10. Sci Adv. 2025. PMID: 41071892 Free PMC article.
We demonstrate that ATM phosphorylates TRMT10A at serine-28 after DNA damage, promoting BRCA1 recruitment and efficient HR repair. TRMT10A deletion disrupts HR repair, sensitizing cells to PARPis. Moreover, TRMT10A is up-regulated in mCRPC through stabilizati …
We demonstrate that ATM phosphorylates TRMT10A at serine-28 after DNA damage, promoting BRCA1 recruitment and efficient HR repair. …
TRMT10A regulates tRNA-ArgCCT m(1)G9 modification to generate tRNA-derived fragments influencing vasculogenic mimicry formation in glioblastoma.
Wei D, Zhai B, Zeng H, Liu L, Gao H, Xiang S, Liu X, Ma J, Lin Y, Yao Y, Wang P. Wei D, et al. Cell Death Dis. 2025 Mar 26;16(1):209. doi: 10.1038/s41419-025-07548-6. Cell Death Dis. 2025. PMID: 40140670 Free PMC article.
Additionally, GBM patients with low TRMT10A expression have poorer prognoses. In human glioma cells, TRMT10A expression is significantly lower than in human astrocytes. ...This study elucidates the mechanism by which TRMT10A affects VM formation in glioma and …
Additionally, GBM patients with low TRMT10A expression have poorer prognoses. In human glioma cells, TRMT10A expression is sig …
Discovery of a TRMT10A mutation in a case of atypical diabetes: Case report.
Samhani C, Guerci B, Larose C. Samhani C, et al. Diabetes Metab. 2024 Nov;50(6):101572. doi: 10.1016/j.diabet.2024.101572. Epub 2024 Sep 5. Diabetes Metab. 2024. PMID: 39243962 Review.
TRMT10A gene mutation has been linked to syndromic juvenile diabetes in a manner analogous to Wolfram's syndrome. ...In view of the aforementioned data, it is recommended that TRMT10A sequencing be considered in children or adults with early-onset diabetes and a his …
TRMT10A gene mutation has been linked to syndromic juvenile diabetes in a manner analogous to Wolfram's syndrome. ...In view of the a …
Coordination of mRNA and tRNA methylations by TRMT10A.
Ontiveros RJ, Shen H, Stoute J, Yanas A, Cui Y, Zhang Y, Liu KF. Ontiveros RJ, et al. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7782-7791. doi: 10.1073/pnas.1913448117. Epub 2020 Mar 25. Proc Natl Acad Sci U S A. 2020. PMID: 32213595 Free PMC article.
Here, we show that a tRNA methyltransferase, TRMT10A, interacts with an mRNA demethylase FTO (ALKBH9), both in vitro and inside cells. ...We show that TRMT10A ablation not only leads to decreased m(1)G in tRNA but also significantly increases m(6)A levels in mRNA. . …
Here, we show that a tRNA methyltransferase, TRMT10A, interacts with an mRNA demethylase FTO (ALKBH9), both in vitro and inside cells …
TRMT10A Mutation in a Child with Diabetes, Short Stature, Microcephaly and Hypoplastic Kidneys.
Stern E, Vivante A, Barel O, Levy-Shraga Y. Stern E, et al. J Clin Res Pediatr Endocrinol. 2022 Jun 7;14(2):227-232. doi: 10.4274/jcrpe.galenos.2020.2020.0265. Epub 2021 Jan 15. J Clin Res Pediatr Endocrinol. 2022. PMID: 33448213 Free PMC article.
A new syndrome of diabetes, short stature, microcephaly and intellectual disability has been described in association with mutations in the tRNA methyltransferase 10 homologue A (TRMT10A) gene. We report a patient who presented with fasting hyperglycemia, a raised hemoglob …
A new syndrome of diabetes, short stature, microcephaly and intellectual disability has been described in association with mutations in the …
Expanding the Phenotype of TRMT10A Mutations: Case Report and a Review of the Existing Cases.
Şıklar Z, Kontbay T, Colclough K, Patel KA, Berberoğlu M. Şıklar Z, et al. J Clin Res Pediatr Endocrinol. 2023 Feb 27;15(1):90-96. doi: 10.4274/jcrpe.galenos.2021.2021.0110. Epub 2021 Aug 18. J Clin Res Pediatr Endocrinol. 2023. PMID: 34541035 Free PMC article.
The tRNA methyltransferase 10 homologue A (TRMT10A) gene encodes tRNA methyl transferase, and biallelic loss of function mutations cause a recessive syndrome of intellectual disability, microcephaly, short stature and diabetes. ...Spontaneous puberty did not begin until 15 …
The tRNA methyltransferase 10 homologue A (TRMT10A) gene encodes tRNA methyl transferase, and biallelic loss of function mutations ca …
Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B.
Vilardo E, Amman F, Toth U, Kotter A, Helm M, Rossmanith W. Vilardo E, et al. Nucleic Acids Res. 2020 Jun 19;48(11):6157-6169. doi: 10.1093/nar/gkaa353. Nucleic Acids Res. 2020. PMID: 32392304 Free PMC article.
The human genome encodes three TRM10-type enzymes, of which only the mitochondrial TRMT10C was previously characterized in detail, whereas the functional significance of the two presumably nuclear enzymes TRMT10A and TRMT10B remained unexplained. Here we show that TRMT1 …
The human genome encodes three TRM10-type enzymes, of which only the mitochondrial TRMT10C was previously characterized in detail, whereas t …
24 results