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2,527 results

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Page 1
Role of macrophage TRPV4 in inflammation.
Dutta B, Arya RK, Goswami R, Alharbi MO, Sharma S, Rahaman SO. Dutta B, et al. Lab Invest. 2020 Feb;100(2):178-185. doi: 10.1038/s41374-019-0334-6. Epub 2019 Oct 23. Lab Invest. 2020. PMID: 31645630 Free PMC article. Review.
Both neuronal and nonneuronal cells express functional TRPV4, which is responsive to a variety of biochemical and biomechanical stimuli. Emerging discoveries have advanced our understanding of the role of macrophage TRPV4 in numerous inflammatory diseases. ...Deleti …
Both neuronal and nonneuronal cells express functional TRPV4, which is responsive to a variety of biochemical and biomechanical stimu …
Modulation of the TRPV4 ion channel as a therapeutic target for disease.
Grace MS, Bonvini SJ, Belvisi MG, McIntyre P. Grace MS, et al. Pharmacol Ther. 2017 Sep;177:9-22. doi: 10.1016/j.pharmthera.2017.02.019. Epub 2017 Feb 12. Pharmacol Ther. 2017. PMID: 28202366 Free article. Review.
TRPV4 knockout mice and several synthetic pharmacological compounds that selectively target TRPV4 are now available, which has allowed detailed investigation in to the therapeutic potential of this ion channel. ...A lack of observed side-effects in vivo has prompted …
TRPV4 knockout mice and several synthetic pharmacological compounds that selectively target TRPV4 are now available, which has …
TRPV4 Role in Neuropathic Pain Mechanisms in Rodents.
Rodrigues P, Ruviaro NA, Trevisan G. Rodrigues P, et al. Antioxidants (Basel). 2022 Dec 22;12(1):24. doi: 10.3390/antiox12010024. Antioxidants (Basel). 2022. PMID: 36670886 Free PMC article. Review.
In this context, we highlight the transient potential receptor vanilloid 4 (TRPV4), a non-selective cation channel, that can be activated by oxidated compounds. In clinical trials, the TRPV4 antagonist (GSK2798745) has been well-tolerated in healthy volunteers. ...O …
In this context, we highlight the transient potential receptor vanilloid 4 (TRPV4), a non-selective cation channel, that can be activ …
TRPV4 contributes to ER stress and inflammation: implications for Parkinson's disease.
Liu N, Bai L, Lu Z, Gu R, Zhao D, Yan F, Bai J. Liu N, et al. J Neuroinflammation. 2022 Jan 29;19(1):26. doi: 10.1186/s12974-022-02382-5. J Neuroinflammation. 2022. PMID: 35093118 Free PMC article.
Upregulation of TRPV4 via injection of a constructed AAV-TRPV4 aggravated the above movement disorders. The expression of TRPV4 was upregulated in the SN of MPTP-treated mice. Injection of AAV-TRPV4 shRNAi into the SN rescued the number of TH-positive …
Upregulation of TRPV4 via injection of a constructed AAV-TRPV4 aggravated the above movement disorders. The expression of T …
TRPV4 antagonists: a patent review (2015-2020).
Lawhorn BG, Brnardic EJ, Behm DJ. Lawhorn BG, et al. Expert Opin Ther Pat. 2021 Sep;31(9):773-784. doi: 10.1080/13543776.2021.1903432. Epub 2021 Mar 24. Expert Opin Ther Pat. 2021. PMID: 33724130 Review.
Introduction: Transient receptor potential vanilloid 4 (TRPV4) is an ion channel that is widely expressed and is activated by numerous chemical, osmotic and mechanical stimuli. By modulating Ca(2+) entry, TRPV4 regulates cellular signaling associated with a variety …
Introduction: Transient receptor potential vanilloid 4 (TRPV4) is an ion channel that is widely expressed and is activated by numerou …
Endothelial TRPV4 channels and vasodilator reactivity.
Chen YL, Sonkusare SK. Chen YL, et al. Curr Top Membr. 2020;85:89-117. doi: 10.1016/bs.ctm.2020.01.007. Epub 2020 Feb 12. Curr Top Membr. 2020. PMID: 32402646 Free PMC article. Review.
The downstream vasodilatory targets of endothelial TRPV4 channels vary among different vascular beds, potentially contributing to endothelial cell heterogeneity. ...In this chapter, we discuss endothelial TRPV4 channel-dependent signaling mechanisms, the heterogenei …
The downstream vasodilatory targets of endothelial TRPV4 channels vary among different vascular beds, potentially contributing to end …
Endothelial TRPV4 channels in lung edema and injury.
Sonkusare SK, Laubach VE. Sonkusare SK, et al. Curr Top Membr. 2022;89:43-62. doi: 10.1016/bs.ctm.2022.07.001. Epub 2022 Jul 28. Curr Top Membr. 2022. PMID: 36210151 Free PMC article. Review.
TRPV4 channels from capillary endothelial cells, alveolar epithelial cells, and immune cells have been implicated in the pathogenesis of lung injury. Recent studies in endothelium-specific TRPV4 knockout mice point to a central role for endothelial TRPV4 chan …
TRPV4 channels from capillary endothelial cells, alveolar epithelial cells, and immune cells have been implicated in the pathogenesis …
TRPV4-A Missing Link Between Mechanosensation and Immunity.
Michalick L, Kuebler WM. Michalick L, et al. Front Immunol. 2020 Mar 10;11:413. doi: 10.3389/fimmu.2020.00413. eCollection 2020. Front Immunol. 2020. PMID: 32210976 Free PMC article. Review.
Importantly, TRPV4 may present a missing link between mechanical forces and immune responses. This connection has been exemplary highlighted by the demonstrated role of TRPV4 in macrophage activation and subsequent induction of lung injury following mechanical overv …
Importantly, TRPV4 may present a missing link between mechanical forces and immune responses. This connection has been exemplary high …
TRPV4-induced Muller cell gliosis and TNF-alpha elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-kappaB pathway.
Li Q, Cheng Y, Zhang S, Sun X, Wu J. Li Q, et al. J Neuroinflammation. 2021 Nov 17;18(1):271. doi: 10.1186/s12974-021-02315-8. J Neuroinflammation. 2021. PMID: 34789280 Free PMC article.
Transient receptor potential vanilloid 4 (TRPV4) is a pressure-sensitive and calcium-permeable cation channel. TRPV4 is widely distributed in the retina and its sustained activation leads to RGC death; indicating that TRPV4 may be a possible target for glauco …
Transient receptor potential vanilloid 4 (TRPV4) is a pressure-sensitive and calcium-permeable cation channel. TRPV4 is widely …
Cardiac TRPV4 channels.
Onyali VC, Domeier TL. Onyali VC, et al. Curr Top Membr. 2022;89:63-74. doi: 10.1016/bs.ctm.2022.06.004. Epub 2022 Aug 1. Curr Top Membr. 2022. PMID: 36210152
Transient Receptor Potential Vanilloid 4 (TRPV4) is expressed in numerous cell types within the heart, yet the expression levels, subcellular localization, and functional relevance of TRPV4 in cardiac myocytes is under-appreciated. ...This manuscript chapter describ …
Transient Receptor Potential Vanilloid 4 (TRPV4) is expressed in numerous cell types within the heart, yet the expression levels, sub …
2,527 results