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Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy.

Kirtland ME, Tsitoura DC, Durham SR, Shamji MH. Kirtland ME, et al. Among authors: tsitoura dc. Front Immunol. 2020 Nov 12;11:599083. doi: 10.3389/fimmu.2020.599083. eCollection 2020. Front Immunol. 2020. PMID: 33281825 Free PMC article. Review.

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Immunomodulation: the future cure for allergic diseases.

Tsitoura DC, Tassios Y. Tsitoura DC, et al. Ann N Y Acad Sci. 2006 Nov;1088:100-15. doi: 10.1196/annals.1366.026. Ann N Y Acad Sci. 2006. PMID: 17192559 Review.

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Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model.

Proud PC, Tsitoura D, Watson RJ, Chua BY, Aram MJ, Bewley KR, Cavell BE, Cobb R, Dowall S, Fotheringham SA, Ho CMK, Lucas V, Ngabo D, Rayner E, Ryan KA, Slack GS, Thomas S, Wand NI, Yeates P, Demaison C, Zeng W, Holmes I, Jackson DC, Bartlett NW, Mercuri F, Carroll MW. Proud PC, et al. Among authors: tsitoura d. EBioMedicine. 2021 Jan;63:103153. doi: 10.1016/j.ebiom.2020.103153. Epub 2020 Dec 3. EBioMedicine. 2021. PMID: 33279857 Free PMC article.

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Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial.

Ellis AK, Tsitoura DC, Quint D, Powley W, Lee LA. Ellis AK, et al. Among authors: tsitoura dc. Clin Exp Allergy. 2017 Sep;47(9):1193-1203. doi: 10.1111/cea.12974. Epub 2017 Aug 11. Clin Exp Allergy. 2017. PMID: 28681506 Clinical Trial.

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Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist.

Holland C, van Drunen C, Denyer J, Smart K, Segboer C, Terreehorst I, Newlands A, Beerahee M, Fokkens W, Tsitoura DC. Holland C, et al. Among authors: tsitoura dc. Br J Clin Pharmacol. 2014 May;77(5):777-88. doi: 10.1111/bcp.12219. Br J Clin Pharmacol. 2014. PMID: 23909699 Free PMC article. Clinical Trial.

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Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma.

Biggadike K, Ahmed M, Ball DI, Coe DM, Dalmas Wilk DA, Edwards CD, Gibbon BH, Hardy CJ, Hermitage SA, Hessey JO, Hillegas AE, Hughes SC, Lazarides L, Lewell XQ, Lucas A, Mallett DN, Price MA, Priest FM, Quint DJ, Shah P, Sitaram A, Smith SA, Stocker R, Trivedi NA, Tsitoura DC, Weller V. Biggadike K, et al. Among authors: tsitoura dc. J Med Chem. 2016 Mar 10;59(5):1711-26. doi: 10.1021/acs.jmedchem.5b01647. Epub 2016 Feb 10. J Med Chem. 2016. PMID: 26861551

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Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement.

Tsitoura D, Ambery C, Price M, Powley W, Garthside S, Biggadike K, Quint D. Tsitoura D, et al. Clin Pharmacol Ther. 2015 Oct;98(4):369-80. doi: 10.1002/cpt.157. Clin Pharmacol Ther. 2015. PMID: 26044169 Clinical Trial.

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Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice.

Deng J, Yeung VP, Tsitoura D, DeKruyff RH, Umetsu DT, Levy S. Deng J, et al. Among authors: tsitoura d. J Immunol. 2000 Nov 1;165(9):5054-61. doi: 10.4049/jimmunol.165.9.5054. J Immunol. 2000. PMID: 11046035 Free article.

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Provocation of nonallergic rhinitis subjects in response to simulated weather conditions using an environmental exposure chamber model.

Bernstein JA, Salapatek AM, Lee JS, Nelson V, Wilson D, D'Angelo P, Tsitoura D, Murdoch R, Patel D. Bernstein JA, et al. Among authors: tsitoura d. Allergy Asthma Proc. 2012 Jul-Aug;33(4):333-40. doi: 10.2500/aap.2012.33.3579. Epub 2012 Jul 3. Allergy Asthma Proc. 2012. PMID: 22762553

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Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells.

Tsitoura DC, Rothman PB. Tsitoura DC, et al. J Clin Invest. 2004 Feb;113(4):619-27. doi: 10.1172/JCI18975. J Clin Invest. 2004. PMID: 14966571 Free PMC article.

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