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Page 1
Targeting TSLP in Asthma.
Parnes JR, Molfino NA, Colice G, Martin U, Corren J, Menzies-Gow A. Parnes JR, et al. J Asthma Allergy. 2022 Jun 3;15:749-765. doi: 10.2147/JAA.S275039. eCollection 2022. J Asthma Allergy. 2022. PMID: 35685846 Free PMC article. Review.
Tezepelumab, the TSLP inhibitor farthest along in clinical development, is a human monoclonal antibody (IgG2lambda) that binds specifically to TSLP, preventing interactions with its heterodimeric receptor. ...This review presents the rationale for targeting TSLP …
Tezepelumab, the TSLP inhibitor farthest along in clinical development, is a human monoclonal antibody (IgG2lambda) that binds specif …
Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses.
Nakajima S, Kabata H, Kabashima K, Asano K. Nakajima S, et al. Allergol Int. 2020 Apr;69(2):197-203. doi: 10.1016/j.alit.2020.01.001. Epub 2020 Jan 21. Allergol Int. 2020. PMID: 31974038 Free article. Review.
Biological functions of TSLP require heterodimer formation between the TSLP receptor (TSLPR) and IL-7 receptor-alpha, which polarize dendritic cells to induce type 2 inflammation and directly expand and/or activate Th2 cells, group 2 innate lymphoid cells, basophils …
Biological functions of TSLP require heterodimer formation between the TSLP receptor (TSLPR) and IL-7 receptor-alpha, which po …
Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma.
Smolinska S, Antolín-Amérigo D, Popescu FD, Jutel M. Smolinska S, et al. Int J Mol Sci. 2023 Aug 12;24(16):12725. doi: 10.3390/ijms241612725. Int J Mol Sci. 2023. PMID: 37628907 Free PMC article. Review.
It is primarily produced by epithelial cells and functions as a potent immune system activator. TSLP acts through interaction with its receptor complex, composed of the TSLP receptor (TSLPR) and interleukin-7 receptor alpha chain (IL-7Ralpha), activating downstream …
It is primarily produced by epithelial cells and functions as a potent immune system activator. TSLP acts through interaction with it …
TSLP: from allergy to cancer.
Corren J, Ziegler SF. Corren J, et al. Nat Immunol. 2019 Dec;20(12):1603-1609. doi: 10.1038/s41590-019-0524-9. Epub 2019 Nov 19. Nat Immunol. 2019. PMID: 31745338 Review.
While the role of TSLP in type 2 immune responses has been investigated extensively, recent studies have found an expanding role for TSLP in inflammatory diseases and cancer. In this Review, we will highlight major recent advances in TSLP biology, along with …
While the role of TSLP in type 2 immune responses has been investigated extensively, recent studies have found an expanding role for …
TSLP as druggable target - a silver-lining for atopic diseases?
Adhikary PP, Tan Z, Page BDG, Hedtrich S. Adhikary PP, et al. Pharmacol Ther. 2021 Jan;217:107648. doi: 10.1016/j.pharmthera.2020.107648. Epub 2020 Aug 3. Pharmacol Ther. 2021. PMID: 32758645 Review.
In experimental settings, the inhibition or knockout of TSLP signaling has shown great therapeutic potential. This, in conjunction with the increasing knowledge about the central role of TSLP in the pathogenesis of atopic diseases, has sparked an interest in TSLP …
In experimental settings, the inhibition or knockout of TSLP signaling has shown great therapeutic potential. This, in conjunction wi …
Development of an inhaled anti-TSLP therapy for asthma.
O'Byrne PM, Panettieri RA Jr, Taube C, Brindicci C, Fleming M, Altman P. O'Byrne PM, et al. Pulm Pharmacol Ther. 2023 Feb;78:102184. doi: 10.1016/j.pupt.2022.102184. Epub 2022 Dec 17. Pulm Pharmacol Ther. 2023. PMID: 36535465 Review.
TSLP plays a role in asthma pathogenesis as an upstream cytokine, and data suggest that TSLP blockade with the anti-TSLP monoclonal antibody, tezepelumab, could be efficacious in a broad asthma population. ...Currently in development, ecleralimab (CSJ117) rep …
TSLP plays a role in asthma pathogenesis as an upstream cytokine, and data suggest that TSLP blockade with the anti-TSLP …
TSLP Inhibitors for Asthma: Current Status and Future Prospects.
Matera MG, Rogliani P, Calzetta L, Cazzola M. Matera MG, et al. Drugs. 2020 Apr;80(5):449-458. doi: 10.1007/s40265-020-01273-4. Drugs. 2020. PMID: 32078149 Review.
Accordingly, targeting of TSLP and TSLP-mediated signalling is considered as an attractive therapeutic strategy to asthma. ...Since new information suggests that targeting TSLP may be more likely to improve day-to-day asthma symptoms, in contrast to targeting …
Accordingly, targeting of TSLP and TSLP-mediated signalling is considered as an attractive therapeutic strategy to asthma. ... …
Airway hyperresponsiveness correlates with airway TSLP in asthma independent of eosinophilic inflammation.
Andreasson LM, Dyhre-Petersen N, Hvidtfeldt M, Jørgensen GØ, Von Bülow A, Klein DK, Uller L, Erjefält J, Porsbjerg C, Sverrild A. Andreasson LM, et al. J Allergy Clin Immunol. 2024 Apr;153(4):988-997.e11. doi: 10.1016/j.jaci.2023.11.915. Epub 2023 Dec 9. J Allergy Clin Immunol. 2024. PMID: 38081546
TSLP may also induce AHR via a direct effect on airway smooth muscle and mast cells, independently of type-2 inflammation, although association between airway TSLP and AHR across asthma phenotypes has been described sparsely. ...CONCLUSIONS: The association between …
TSLP may also induce AHR via a direct effect on airway smooth muscle and mast cells, independently of type-2 inflammation, although a …
Disrupting TSLP-TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases.
Adhikary PP, Idowu T, Tan Z, Hoang C, Shanta S, Dumbani M, Mappalakayil L, Awasthi B, Bermudez M, Weiner J, Beule D, Wolber G, Page BD, Hedtrich S. Adhikary PP, et al. EMBO Mol Med. 2024 Jul;16(7):1630-1656. doi: 10.1038/s44321-024-00085-3. Epub 2024 Jun 14. EMBO Mol Med. 2024. PMID: 38877290 Free PMC article.
Thymic stromal lymphopoietin (TSLP) is a key player in atopic diseases, which has sparked great interest in therapeutically targeting TSLP. Yet, no small-molecule TSLP inhibitors exist due to the challenges of disrupting the protein-protein interaction betwee …
Thymic stromal lymphopoietin (TSLP) is a key player in atopic diseases, which has sparked great interest in therapeutically targeting …
Severe Asthmatic Responses: The Impact of TSLP.
Theofani E, Tsitsopoulou A, Morianos I, Semitekolou M. Theofani E, et al. Int J Mol Sci. 2023 Apr 20;24(8):7581. doi: 10.3390/ijms24087581. Int J Mol Sci. 2023. PMID: 37108740 Free PMC article. Review.
Numerous studies in both humans and mice have provided major insights pertinent to the role of TSLP in the initiation and propagation of asthmatic responses. Undoubtedly, the magnitude of TSLP in asthma pathogenesis is highlighted by the fact that the FDA recently a …
Numerous studies in both humans and mice have provided major insights pertinent to the role of TSLP in the initiation and propagation …
2,590 results