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Page 1
TTC3-Mediated Protein Quality Control, A Potential Mechanism for Cognitive Impairment.
Zhou X, Chen X, Hong T, Zhang M, Cai Y, Cui L. Zhou X, et al. Cell Mol Neurobiol. 2022 Aug;42(6):1659-1669. doi: 10.1007/s10571-021-01060-z. Epub 2021 Feb 27. Cell Mol Neurobiol. 2022. PMID: 33638766 Free PMC article. Review.
The tetrapeptide repeat domain 3 (TTC3) gene falls within Down's syndrome (DS) critical region. Cognitive impairment is a common phenotype of DS and Alzheimer's disease (AD), and overexpression of TTC3 can accelerate cognitive decline, but the specific mechanism is …
The tetrapeptide repeat domain 3 (TTC3) gene falls within Down's syndrome (DS) critical region. Cognitive impairment is a common phen …
TTC3 contributes to TGF-beta(1)-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.
Kim JH, Ham S, Lee Y, Suh GY, Lee YS. Kim JH, et al. Cell Death Dis. 2019 Jan 29;10(2):92. doi: 10.1038/s41419-019-1308-8. Cell Death Dis. 2019. PMID: 30696809 Free PMC article.
TGF-beta(1) reduced SMURF2 levels and TTC3 overexpression led to a further decrease in SMURF2 levels, while TTC3 knockdown inhibited TGF-beta(1)-induced SMURF2 reduction. In cell and in vitro ubiquitylation assays demonstrated TTC3-mediated SMURF2 ubiquitylat …
TGF-beta(1) reduced SMURF2 levels and TTC3 overexpression led to a further decrease in SMURF2 levels, while TTC3 knockdown inh …
Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b.
Cai L, Qi B, Wu X, Peng S, Zhou G, Wei Y, Xu J, Chen S, Liu S. Cai L, et al. J Mol Cell Cardiol. 2019 May;130:10-22. doi: 10.1016/j.yjmcc.2019.03.007. Epub 2019 Mar 12. J Mol Cell Cardiol. 2019. PMID: 30876857
Forced expression of circ-Ttc3 in cardiomyocytes counteracted hypoxia-induced ATP depletion and apoptotic death, in sharp contrast to circ-Ttc3 knockdown. ...Conversely, knockdown of Arl2 partially abolished the beneficial effects of circ-Ttc3 overexpression …
Forced expression of circ-Ttc3 in cardiomyocytes counteracted hypoxia-induced ATP depletion and apoptotic death, in sharp contrast to …
Overexpressed TTC3 Protein Tends to be Cleaved into Fragments and Form Aggregates in the Nucleus.
Gong Y, Wang K, Xiao SP, Mi P, Li W, Shang Y, Dou F. Gong Y, et al. Neuromolecular Med. 2019 Mar;21(1):85-96. doi: 10.1007/s12017-018-8509-7. Epub 2018 Sep 10. Neuromolecular Med. 2019. PMID: 30203323
In addition, our previous work shows that TTC3 also regulates the degradation of DNA polymerase gamma and over-expressed TTC3 protein tends to form insoluble aggregates in cells. In this study, we focus on the solubility and intracellular localization of TTC3 …
In addition, our previous work shows that TTC3 also regulates the degradation of DNA polymerase gamma and over-expressed TTC3 …
Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3.
Endo R, Chen YK, Burke J, Takashima N, Suryawanshi N, Hui KK, Miyazaki T, Tanaka M. Endo R, et al. Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2211522120. doi: 10.1073/pnas.2211522120. Epub 2023 Mar 14. Proc Natl Acad Sci U S A. 2023. PMID: 36917672 Free PMC article.
However, the overaccumulated TTC3 protein in turn caused dendritic abnormalities and reduced surface-localized GABA(A) receptors during neuronal development. Ltn1 KO mice showed behavioral deficits associated with cognitive disorders, a subset of which were restored by …
However, the overaccumulated TTC3 protein in turn caused dendritic abnormalities and reduced surface-localized GABA(A) receptors duri …
Circular RNA circ-Ttc3 protects HaCaT cells from hypoxic injury by downregulation of miR-449a.
Yu L, Wang Q, Liu N, Zhao J, Yu J, Tao S. Yu L, et al. IUBMB Life. 2020 Mar;72(3):505-514. doi: 10.1002/iub.2236. Epub 2020 Feb 11. IUBMB Life. 2020. PMID: 32043754 Free article.
RESULTS: Hypoxia induced apoptosis and declined viability in HaCaT cells. Circ-Ttc3 expression was enhanced after transfection with circ-Ttc3 expressing vector. Overexpressing circ-Ttc3 raised viability and reduced apoptosis in HaCaT cells. Moreover, miR-449a …
RESULTS: Hypoxia induced apoptosis and declined viability in HaCaT cells. Circ-Ttc3 expression was enhanced after transfection with c …
circ-Ttc3 alleviates LPS-induced neuronal injury via stabilizing RBFOX1 to inhibit inflammation and oxidative stress.
Zhang Y, Zhu Y, Li Q, Shi Q, Li L. Zhang Y, et al. Mol Biol Rep. 2025 Dec 28;53(1):219. doi: 10.1007/s11033-025-11379-1. Mol Biol Rep. 2025. PMID: 41456226
Mechanistically, bioinformatics and RNA immunoprecipitation (RIP) assays identified RBFOX1 as a direct binding protein of circ-Ttc3. circ-Ttc3 increased RBFOX1 protein levels by enhancing its stability, as shown by cycloheximide chase assays. Functional rescue exper …
Mechanistically, bioinformatics and RNA immunoprecipitation (RIP) assays identified RBFOX1 as a direct binding protein of circ-Ttc3. …
Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy.
Kong D, Zhang Z, Chen L, Huang W, Zhang F, Wang L, Wang Y, Cao P, Zheng S. Kong D, et al. Redox Biol. 2020 Sep;36:101600. doi: 10.1016/j.redox.2020.101600. Epub 2020 May 30. Redox Biol. 2020. Retraction in: Redox Biol. 2025 Jul;84:103690. doi: 10.1016/j.redox.2025.103690. PMID: 32526690 Free PMC article. Retracted.
The mechanism of degradative polyubiquitylation of Smad2 and Smad3 is likely through inhibiting tetratricopeptide repeat domain 3 (TTC3) and by inducing ubiquitylation and proteasomal degradation of Smad ubiquitination regulatory factor 2 (SMURF2), which on account of the …
The mechanism of degradative polyubiquitylation of Smad2 and Smad3 is likely through inhibiting tetratricopeptide repeat domain 3 (TTC3 …
lncRNA Ttc3-209 Promotes the Apoptosis of Retinal Ganglion Cells in Retinal Ischemia Reperfusion Injury by Targeting the miR-484/Wnt8a Axis.
Zhang R, Feng Y, Lu J, Ge Y, Li H. Zhang R, et al. Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):13. doi: 10.1167/iovs.62.3.13. Invest Ophthalmol Vis Sci. 2021. PMID: 33687475 Free PMC article.
Mechanistically, lncRNA Ttc3-209 is a ceRNA that competitively binds to miR-484 and upregulates the translation of its target (Wnt8a mRNA), thus promoting apoptosis in RGCs. CONCLUSIONS: Reducing the expression of lncRNA Ttc3-209 had a protective effect against apop …
Mechanistically, lncRNA Ttc3-209 is a ceRNA that competitively binds to miR-484 and upregulates the translation of its target (Wnt8a …
84 results