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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
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1980 1
1981 1
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1983 1
1984 3
1985 4
1986 3
1987 2
1988 3
1989 6
1990 6
1991 12
1992 13
1993 17
1994 12
1995 17
1996 23
1997 22
1998 28
1999 24
2000 39
2001 37
2002 52
2003 56
2004 43
2005 57
2006 52
2007 52
2008 55
2009 64
2010 64
2011 68
2012 68
2013 66
2014 82
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2016 93
2017 129
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2019 189
2020 231
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2024 274
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2026 178

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3,042 results

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Page 1
Titin (TTN): from molecule to modifications, mechanics, and medical significance.
Loescher CM, Hobbach AJ, Linke WA. Loescher CM, et al. Cardiovasc Res. 2022 Nov 10;118(14):2903-2918. doi: 10.1093/cvr/cvab328. Cardiovasc Res. 2022. PMID: 34662387 Free PMC article. Review.
In this context, new insights into the key pathomechanisms of human cardiomyopathy due to a truncation in the titin gene (TTN) are discussed. Along the way, we touch on the potential for titin to be therapeutically targeted to treat acquired or inherited cardiac conditions …
In this context, new insights into the key pathomechanisms of human cardiomyopathy due to a truncation in the titin gene (TTN) are di …
Exploring TTN variants as genetic insights into cardiomyopathy pathogenesis and potential emerging clues to molecular mechanisms in cardiomyopathies.
Jolfayi AG, Kohansal E, Ghasemi S, Naderi N, Hesami M, MozafaryBazargany M, Moghadam MH, Fazelifar AF, Maleki M, Kalayinia S. Jolfayi AG, et al. Sci Rep. 2024 Mar 4;14(1):5313. doi: 10.1038/s41598-024-56154-7. Sci Rep. 2024. PMID: 38438525 Free PMC article. Review.
Diagnosing TTN pathogenic variants has important implications for patient management and genetic counseling. ...With the increasing use of next-generation sequencing (NGS), a high number of variants in the TTN gene have been detected in patients with cardiomyopathie …
Diagnosing TTN pathogenic variants has important implications for patient management and genetic counseling. ...With the increasing u …
Clinical Significance of Variants in the TTN Gene in a Large Cohort of Patients With Sporadic Dilated Cardiomyopathy.
Xiao L, Li C, Sun Y, Chen Y, Wei H, Hu D, Yu T, Li X, Jin L, Shi L, Marian AJ, Wang DW. Xiao L, et al. Front Cardiovasc Med. 2021 Apr 30;8:657689. doi: 10.3389/fcvm.2021.657689. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 33996946 Free PMC article.
Background: Mutations in the TTN gene are the most common causes of dilated cardiomyopathy (DCM). The clinical significance of TTN gene variants remains inadequately understood. ...Pathogenic TTN missense variants were also enriched in DCM as compared with th …
Background: Mutations in the TTN gene are the most common causes of dilated cardiomyopathy (DCM). The clinical significance of TTN …
CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants.
Ghahremani S, Kanwal A, Pettinato A, Ladha F, Legere N, Thakar K, Zhu Y, Tjong H, Wilderman A, Stump WT, Greenberg L, Greenberg MJ, Cotney J, Wei CL, Hinson JT. Ghahremani S, et al. Circulation. 2024 Apr 16;149(16):1285-1297. doi: 10.1161/CIRCULATIONAHA.123.063972. Epub 2024 Jan 18. Circulation. 2024. PMID: 38235591 Free PMC article.
We performed guide RNA screening with custom TTN reporter assays, agarose gel electrophoresis to quantify TTN protein levels and isoforms, and RNA sequencing to identify molecular consequences of TTN activation. ...Increasing TTN protein levels normali …
We performed guide RNA screening with custom TTN reporter assays, agarose gel electrophoresis to quantify TTN protein levels a …
TTN-AS1 as a potential diagnostic and prognostic biomarker for multiple cancers.
Zheng QX, Wang J, Gu XY, Huang CH, Chen C, Hong M, Chen Z. Zheng QX, et al. Biomed Pharmacother. 2021 Mar;135:111169. doi: 10.1016/j.biopha.2020.111169. Epub 2021 Feb 1. Biomed Pharmacother. 2021. PMID: 33433359 Free article. Review.
There is also evidence that some aberrantly regulated lncRNAs function as oncogenes or tumor suppressor genes in various cancers. For example, TTN-AS1 is a lncRNA that binds to titin mRNA (TTN) and has pro-oncogenic effects in many cancers. ...Furthermore, increased …
There is also evidence that some aberrantly regulated lncRNAs function as oncogenes or tumor suppressor genes in various cancers. For exampl …
Truncations of titin causing dilated cardiomyopathy.
Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. Herman DS, et al. N Engl J Med. 2012 Feb 16;366(7):619-28. doi: 10.1056/NEJMoa1110186. N Engl J Med. 2012. PMID: 22335739 Free PMC article.
TTN mutations cosegregated with dilated cardiomyopathy in families (combined lod score, 11.1) with high (>95%) observed penetrance after the age of 40 years. ...Defining the functional effects of TTN truncating mutations should improve our understanding of the pa …
TTN mutations cosegregated with dilated cardiomyopathy in families (combined lod score, 11.1) with high (>95%) observed penetrance …
Analysis of TTN Truncating Variants in >74 000 Cases Reveals New Clinically Relevant Gene Regions.
Vatta M, Regalado E, Parfenov M, Swartzlander D, Nagl A, Mannello M, Lewis R, Clemens D, Garcia J, Ellsworth RE, Morales A, Ting YL, Aradhya S. Vatta M, et al. Circ Genom Precis Med. 2025 Apr;18(2):e004982. doi: 10.1161/CIRCGEN.124.004982. Epub 2025 Feb 19. Circ Genom Precis Med. 2025. PMID: 39968638 Free PMC article.
BACKGROUND: Truncating variants (TTNtvs) in the titin (TTN) gene have been associated with cardiomyopathies or arrhythmias (C/A) and autosomal recessive neuromuscular diseases (NM). ...CONCLUSIONS: In the largest single-site cohort of C/A and NM cases with TTNtvs, an enric …
BACKGROUND: Truncating variants (TTNtvs) in the titin (TTN) gene have been associated with cardiomyopathies or arrhythmias (C/A) and …
Recent Advances in Pathophysiology and Management of Transient Tachypnea of Newborn.
Alhassen Z, Vali P, Guglani L, Lakshminrusimha S, Ryan RM. Alhassen Z, et al. J Perinatol. 2021 Jan;41(1):6-16. doi: 10.1038/s41372-020-0757-3. Epub 2020 Aug 4. J Perinatol. 2021. PMID: 32753712 Free PMC article. Review.
Transient tachypnea of newborn (TTN) results from failure of the newborn to effectively clear the fetal lung fluid soon after birth. ...Recent evidence also suggests that TTN may be associated with wheezing syndromes later in childhood. New imaging modalities such a …
Transient tachypnea of newborn (TTN) results from failure of the newborn to effectively clear the fetal lung fluid soon after birth. …
Prognostic significance of long noncoding RNA TTN-AS1 in various malignancies.
Lin G, Liu X, Cong C, Xu L. Lin G, et al. Cancer Rep (Hoboken). 2023 Oct;6(10):e1876. doi: 10.1002/cnr2.1876. Epub 2023 Aug 2. Cancer Rep (Hoboken). 2023. PMID: 37528740 Free PMC article.
BACKGROUND: Increasing evidence has demonstrated that high TTN-AS1 expression is highly related to poor prognosis in diverse human cancers. However, the findings concerning the prognostic value of TTN-AS1 were inconsistent, as these conclusions were usually drawn wi …
BACKGROUND: Increasing evidence has demonstrated that high TTN-AS1 expression is highly related to poor prognosis in diverse human ca …
An overview of insights and updates on TTN mutations in cardiomyopathies.
Saha S, Temaj G, Telkoparan-Akillilar P, Chichiarelli S, Saso L. Saha S, et al. Front Pharmacol. 2025 Oct 20;16:1668544. doi: 10.3389/fphar.2025.1668544. eCollection 2025. Front Pharmacol. 2025. PMID: 41190030 Free PMC article. Review.
Within the heart muscle, the largest sarcomeric protein is titin (TTN). The heart expresses two principal isoforms, N2B and N2BA, which arise from alternative splicing of the TTN gene. ...The discovery of a rare TTN missense variant that co-segregates with re …
Within the heart muscle, the largest sarcomeric protein is titin (TTN). The heart expresses two principal isoforms, N2B and N2BA, whi …
3,042 results