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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1975 1
1977 2
1980 1
1981 1
1982 2
1983 1
1984 3
1985 4
1986 3
1987 2
1988 3
1989 6
1990 6
1991 12
1992 13
1993 17
1994 12
1995 17
1996 23
1997 22
1998 28
1999 24
2000 39
2001 37
2002 52
2003 56
2004 43
2005 57
2006 52
2007 52
2008 55
2009 64
2010 64
2011 68
2012 68
2013 66
2014 83
2015 82
2016 93
2017 129
2018 148
2019 190
2020 230
2021 268
2022 247
2023 218
2024 192

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2,534 results

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Page 1
Titin (TTN): from molecule to modifications, mechanics, and medical significance.
Loescher CM, Hobbach AJ, Linke WA. Loescher CM, et al. Cardiovasc Res. 2022 Nov 10;118(14):2903-2918. doi: 10.1093/cvr/cvab328. Cardiovasc Res. 2022. PMID: 34662387 Free PMC article. Review.
In this context, new insights into the key pathomechanisms of human cardiomyopathy due to a truncation in the titin gene (TTN) are discussed. Along the way, we touch on the potential for titin to be therapeutically targeted to treat acquired or inherited cardiac conditions …
In this context, new insights into the key pathomechanisms of human cardiomyopathy due to a truncation in the titin gene (TTN) are di …
Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy.
Ceyhan-Birsoy O, Agrawal PB, Hidalgo C, Schmitz-Abe K, DeChene ET, Swanson LC, Soemedi R, Vasli N, Iannaccone ST, Shieh PB, Shur N, Dennison JM, Lawlor MW, Laporte J, Markianos K, Fairbrother WG, Granzier H, Beggs AH. Ceyhan-Birsoy O, et al. Neurology. 2013 Oct 1;81(14):1205-14. doi: 10.1212/WNL.0b013e3182a6ca62. Epub 2013 Aug 23. Neurology. 2013. PMID: 23975875 Free PMC article.
CONCLUSIONS: Our study identifies truncating TTN mutations as a cause of congenital myopathy that is reported as CNM. Unlike the classic CNM genes that are all involved in excitation-contraction coupling at the triad, TTN encodes the giant sarcomeric protein titin, …
CONCLUSIONS: Our study identifies truncating TTN mutations as a cause of congenital myopathy that is reported as CNM. Unlike the clas …
TTN-AS1 as a potential diagnostic and prognostic biomarker for multiple cancers.
Zheng QX, Wang J, Gu XY, Huang CH, Chen C, Hong M, Chen Z. Zheng QX, et al. Biomed Pharmacother. 2021 Mar;135:111169. doi: 10.1016/j.biopha.2020.111169. Epub 2021 Feb 1. Biomed Pharmacother. 2021. PMID: 33433359 Free article. Review.
There is also evidence that some aberrantly regulated lncRNAs function as oncogenes or tumor suppressor genes in various cancers. For example, TTN-AS1 is a lncRNA that binds to titin mRNA (TTN) and has pro-oncogenic effects in many cancers. ...Furthermore, increased …
There is also evidence that some aberrantly regulated lncRNAs function as oncogenes or tumor suppressor genes in various cancers. For exampl …
Prevalence of TTN mutations in patients with dilated cardiomyopathy : A meta-analysis.
Fang HJ, Liu BP. Fang HJ, et al. Herz. 2020 Dec;45(Suppl 1):29-36. doi: 10.1007/s00059-019-4825-4. Epub 2019 Jun 17. Herz. 2020. PMID: 31209521 Review. English.
A meta-analysis was performed to assess the prevalence of TTN mutations in patients with dilated cardiomyopathy (DCM). Prevalence point estimates and 95% confidence intervals were computed using the logit transformation formula. ...In conclusion, the present analysis sugge …
A meta-analysis was performed to assess the prevalence of TTN mutations in patients with dilated cardiomyopathy (DCM). Prevalence poi …
Truncations of titin causing dilated cardiomyopathy.
Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. Herman DS, et al. N Engl J Med. 2012 Feb 16;366(7):619-28. doi: 10.1056/NEJMoa1110186. N Engl J Med. 2012. PMID: 22335739 Free PMC article.
TTN mutations cosegregated with dilated cardiomyopathy in families (combined lod score, 11.1) with high (>95%) observed penetrance after the age of 40 years. ...Defining the functional effects of TTN truncating mutations should improve our understanding of the pa …
TTN mutations cosegregated with dilated cardiomyopathy in families (combined lod score, 11.1) with high (>95%) observed penetrance …
TTN mutations predict a poor prognosis in patients with thyroid cancer.
Han X, Chen J, Wang J, Xu J, Liu Y. Han X, et al. Biosci Rep. 2022 Jul 29;42(7):BSR20221168. doi: 10.1042/BSR20221168. Biosci Rep. 2022. PMID: 35766333 Free PMC article.
OBJECTIVE: We aimed to investigate the relationship between titin (TTN) gene mutations and thyroid cancer (THCA) and to explore the feasibility of the TTN gene as a potential prognostic indicator of THCA. ...Cox regression analysis demonstrated that TTN gene …
OBJECTIVE: We aimed to investigate the relationship between titin (TTN) gene mutations and thyroid cancer (THCA) and to explore the f …
Recent Advances in Pathophysiology and Management of Transient Tachypnea of Newborn.
Alhassen Z, Vali P, Guglani L, Lakshminrusimha S, Ryan RM. Alhassen Z, et al. J Perinatol. 2021 Jan;41(1):6-16. doi: 10.1038/s41372-020-0757-3. Epub 2020 Aug 4. J Perinatol. 2021. PMID: 32753712 Review.
Transient tachypnea of newborn (TTN) results from failure of the newborn to effectively clear the fetal lung fluid soon after birth. ...Recent evidence also suggests that TTN may be associated with wheezing syndromes later in childhood. New imaging modalities such a …
Transient tachypnea of newborn (TTN) results from failure of the newborn to effectively clear the fetal lung fluid soon after birth. …
Exploring TTN variants as genetic insights into cardiomyopathy pathogenesis and potential emerging clues to molecular mechanisms in cardiomyopathies.
Jolfayi AG, Kohansal E, Ghasemi S, Naderi N, Hesami M, MozafaryBazargany M, Moghadam MH, Fazelifar AF, Maleki M, Kalayinia S. Jolfayi AG, et al. Sci Rep. 2024 Mar 4;14(1):5313. doi: 10.1038/s41598-024-56154-7. Sci Rep. 2024. PMID: 38438525 Free PMC article. Review.
Diagnosing TTN pathogenic variants has important implications for patient management and genetic counseling. ...With the increasing use of next-generation sequencing (NGS), a high number of variants in the TTN gene have been detected in patients with cardiomyopathie …
Diagnosing TTN pathogenic variants has important implications for patient management and genetic counseling. ...With the increasing u …
Titin mutations and muscle disease.
Kellermayer D, Smith JE 3rd, Granzier H. Kellermayer D, et al. Pflugers Arch. 2019 May;471(5):673-682. doi: 10.1007/s00424-019-02272-5. Epub 2019 Mar 27. Pflugers Arch. 2019. PMID: 30919088 Free PMC article. Review.
The introduction of next-generation sequencing technology has revealed that mutations in the gene that encodes titin (TTN) are linked to multiple skeletal and cardiac myopathies. The most prominent of these myopathies is dilated cardiomyopathy (DCM). Over 60 genes are link …
The introduction of next-generation sequencing technology has revealed that mutations in the gene that encodes titin (TTN) are linked …
TTN truncation variants produce sarcomere-integrating proteins of uncertain functional significance.
Hinson JT, Campbell SG. Hinson JT, et al. J Clin Invest. 2024 Jan 16;134(2):e175206. doi: 10.1172/JCI175206. J Clin Invest. 2024. PMID: 38226618 Free PMC article.
Two reports in this issue of the JCI shed light on a potential mechanism involving truncated TTN sarcomere integration and the potential for disruption of sarcomere structural integrity. Kellermayer, Tordai, and colleagues confirmed the presence of truncated TTN pro …
Two reports in this issue of the JCI shed light on a potential mechanism involving truncated TTN sarcomere integration and the potent …
2,534 results