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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 5
2004 4
2005 7
2006 6
2007 11
2008 13
2009 11
2010 12
2011 17
2012 11
2013 14
2014 5
2015 8
2016 9
2017 7
2018 8
2019 8
2020 16
2021 11
2022 14
2023 8
2024 8

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195 results

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Page 1
A comprehensive map of molecular drug targets.
Santos R, Ursu O, Gaulton A, Bento AP, Donadi RS, Bologa CG, Karlsson A, Al-Lazikani B, Hersey A, Oprea TI, Overington JP. Santos R, et al. Among authors: oprea ti. Nat Rev Drug Discov. 2017 Jan;16(1):19-34. doi: 10.1038/nrd.2016.230. Epub 2016 Dec 2. Nat Rev Drug Discov. 2017. PMID: 27910877 Free PMC article. Review.
How many rare diseases are there?
Haendel M, Vasilevsky N, Unni D, Bologa C, Harris N, Rehm H, Hamosh A, Baynam G, Groza T, McMurry J, Dawkins H, Rath A, Thaxton C, Bocci G, Joachimiak MP, Köhler S, Robinson PN, Mungall C, Oprea TI. Haendel M, et al. Among authors: oprea ti. Nat Rev Drug Discov. 2020 Feb;19(2):77-78. doi: 10.1038/d41573-019-00180-y. Nat Rev Drug Discov. 2020. PMID: 32020066 Free PMC article.
Therapies for rare diseases: therapeutic modalities, progress and challenges ahead.
Tambuyzer E, Vandendriessche B, Austin CP, Brooks PJ, Larsson K, Miller Needleman KI, Valentine J, Davies K, Groft SC, Preti R, Oprea TI, Prunotto M. Tambuyzer E, et al. Among authors: oprea ti. Nat Rev Drug Discov. 2020 Feb;19(2):93-111. doi: 10.1038/s41573-019-0049-9. Epub 2019 Dec 13. Nat Rev Drug Discov. 2020. PMID: 31836861 Review.
BDDCS applied to over 900 drugs.
Benet LZ, Broccatelli F, Oprea TI. Benet LZ, et al. Among authors: oprea ti. AAPS J. 2011 Dec;13(4):519-47. doi: 10.1208/s12248-011-9290-9. Epub 2011 Aug 5. AAPS J. 2011. PMID: 21818695 Free PMC article.
Next-generation QSAR.
Oprea TI. Oprea TI. Mol Inform. 2011 Mar 14;30(2-3):89. doi: 10.1002/minf.201180001. Mol Inform. 2011. PMID: 27466761 No abstract available.
QSAR without borders.
Muratov EN, Bajorath J, Sheridan RP, Tetko IV, Filimonov D, Poroikov V, Oprea TI, Baskin II, Varnek A, Roitberg A, Isayev O, Curtarolo S, Fourches D, Cohen Y, Aspuru-Guzik A, Winkler DA, Agrafiotis D, Cherkasov A, Tropsha A. Muratov EN, et al. Among authors: oprea ti. Chem Soc Rev. 2020 Jun 7;49(11):3525-3564. doi: 10.1039/d0cs00098a. Epub 2020 May 1. Chem Soc Rev. 2020. PMID: 32356548 Free PMC article. Review.
Off-Patent Drug Repositioning.
Avram S, Curpan R, Halip L, Bora A, Oprea TI. Avram S, et al. Among authors: oprea ti. J Chem Inf Model. 2020 Dec 28;60(12):5746-5753. doi: 10.1021/acs.jcim.0c00826. Epub 2020 Sep 15. J Chem Inf Model. 2020. PMID: 32877182
Novel drug targets in 2023.
Avram S, Halip L, Curpan R, Oprea TI. Avram S, et al. Among authors: oprea ti. Nat Rev Drug Discov. 2024 May;23(5):330. doi: 10.1038/d41573-024-00057-9. Nat Rev Drug Discov. 2024. PMID: 38565953 No abstract available.
195 results