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Page 1
Effect of Dietetic Obesity on Testicular Transcriptome in Cynomolgus Monkeys.
Zhang Y, Qi J, Zhao J, Li M, Zhang Y, Hu H, Wei L, Zhou K, Qin H, Qu P, Cao W, Liu E. Zhang Y, et al. Genes (Basel). 2023 Feb 23;14(3):557. doi: 10.3390/genes14030557. Genes (Basel). 2023. PMID: 36980830 Free PMC article.
Among the differentially abundant genes were ten regulatory genes, including IRF1, IRF6, HERC5, HERC6, IFIH1, IFIT2, IFIT5, IFI35, RSAD2, and UBQLNL. Gene ontology (GO) and KEGG pathway analysis was conducted, and we found that processes and pathways associated with the bl …
Among the differentially abundant genes were ten regulatory genes, including IRF1, IRF6, HERC5, HERC6, IFIH1, IFIT2, IFIT5, IFI35, RSAD2, an …
UBQLN Family Members Regulate MYC in Lung Adenocarcinoma Cells.
Shah PP, Beverly LJ. Shah PP, et al. Cancers (Basel). 2023 Jun 28;15(13):3389. doi: 10.3390/cancers15133389. Cancers (Basel). 2023. PMID: 37444499 Free PMC article.
The ubiquilin family (UBQLN) of proteins consists of five closely related members (UBQLN1, UBQLN2, UBQLN3, UBQLN4, and UBQLNL) that have a high degree of similarity at the level of both amino acid and domain structure. ...
The ubiquilin family (UBQLN) of proteins consists of five closely related members (UBQLN1, UBQLN2, UBQLN3, UBQLN4, and UBQLNL) that h …
Genotype×age interaction in human transcriptional ageing.
Kent JW Jr, Göring HH, Charlesworth JC, Drigalenko E, Diego VP, Curran JE, Johnson MP, Dyer TD, Cole SA, Jowett JB, Mahaney MC, Comuzzie AG, Almasy L, Moses EK, Blangero J, Williams-Blangero S. Kent JW Jr, et al. Mech Ageing Dev. 2012 Sep-Oct;133(9-10):581-90. doi: 10.1016/j.mad.2012.07.005. Epub 2012 Jul 31. Mech Ageing Dev. 2012. PMID: 22871458 Free PMC article. Clinical Trial.
We applied a novel SNP genotype age interaction test to one of these candidates, the ubiquilin-like gene UBQLNL, and found evidence of joint cis-association and genotype by age interaction as well as trans-genotype by age interaction for UBQLNL expression. Both U
We applied a novel SNP genotype age interaction test to one of these candidates, the ubiquilin-like gene UBQLNL, and found evidence o …
Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis.
Shah PP, Saurabh K, Kurlawala Z, Vega AA, Siskind LJ, Beverly LJ. Shah PP, et al. Neoplasia. 2022 Mar;25:1-8. doi: 10.1016/j.neo.2021.11.010. Epub 2022 Jan 18. Neoplasia. 2022. PMID: 35063704 Free PMC article.
The Ubiquilin family of proteins (UBQLN) consists of five related proteins (UBQLN1-4 and UBQLNL) that all contain ubiquitin-like (UBL) and ubiquitin-associated (UBA) domains. ...
The Ubiquilin family of proteins (UBQLN) consists of five related proteins (UBQLN1-4 and UBQLNL) that all contain ubiquitin-like (UBL …
The ubiquilin gene family: evolutionary patterns and functional insights.
Marín I. Marín I. BMC Evol Biol. 2014 Mar 28;14:63. doi: 10.1186/1471-2148-14-63. BMC Evol Biol. 2014. PMID: 24674348 Free PMC article.
This exceptional mammalian-specific expansion is the result of the recent emergence of four new genes, three of them (UBQLN3, UBQLN5 and UBQLNL) with precise testis-specific expression patterns that indicate roles in the postmeiotic stages of spermatogenesis. ...
This exceptional mammalian-specific expansion is the result of the recent emergence of four new genes, three of them (UBQLN3, UBQLN5 and …
Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
Gamboa-Meléndez MA, Huerta-Chagoya A, Moreno-Macías H, Vázquez-Cárdenas P, Ordóñez-Sánchez ML, Rodríguez-Guillén R, Riba L, Rodríguez-Torres M, Guerra-García MT, Guillén-Pineda LE, Choudhry S, Del Bosque-Plata L, Canizales-Quinteros S, Pérez-Ortiz G, Escobedo-Aguirre F, Parra A, Lerman-Garber I, Aguilar-Salinas CA, Tusié-Luna MT. Gamboa-Meléndez MA, et al. Diabetes. 2012 Dec;61(12):3314-21. doi: 10.2337/db11-0550. Epub 2012 Aug 24. Diabetes. 2012. PMID: 22923468 Free PMC article.
Twenty-four single nucleotide polymorphisms (SNPs) in or near genes (KCNJ11, PPARG, TCF7L2, SLC30A8, HHEX, CDKN2A/2B, CDKAL1, IGF2BP2, ARHGEF11, JAZF1, CDC123/CAMK1D, FTO, TSPAN8/LGR5, KCNQ1, THADA, ADAMTS9, NOTCH2, NXPH1, RORA, UBQLNL, and RALGPS2) were genotyped in Mexic …
Twenty-four single nucleotide polymorphisms (SNPs) in or near genes (KCNJ11, PPARG, TCF7L2, SLC30A8, HHEX, CDKN2A/2B, CDKAL1, IGF2BP2, ARHGE …
Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies.
Hayes MG, Pluzhnikov A, Miyake K, Sun Y, Ng MC, Roe CA, Below JE, Nicolae RI, Konkashbaev A, Bell GI, Cox NJ, Hanis CL. Hayes MG, et al. Diabetes. 2007 Dec;56(12):3033-44. doi: 10.2337/db07-0482. Epub 2007 Sep 10. Diabetes. 2007. PMID: 17846124

A query of our top approximately 1% of SNPs (P < 0.01) revealed SNPs in or near four genes that showed evidence for association (P < 0.05) in multiple other GWAS interrogated: rs979752 and rs10500641 near UBQLNL and OR52H1 on chromosome 11, rs2773080 and rs3922812 in

A query of our top approximately 1% of SNPs (P < 0.01) revealed SNPs in or near four genes that showed evidence for association (P < 0