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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
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2,794 results

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The following term was not found in PubMed: Sjarqiah
Page 1
UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy.
Smith T, Heger A, Sudbery I. Smith T, et al. Genome Res. 2017 Mar;27(3):491-499. doi: 10.1101/gr.209601.116. Epub 2017 Jan 18. Genome Res. 2017. PMID: 28100584 Free PMC article.
However, bioinformatic methods to leverage the information from UMIs have yet to be formalized. In particular, sequencing errors in the UMI sequence are often ignored or else resolved in an ad hoc manner. We show that errors in the UMI sequence are common and introd …
However, bioinformatic methods to leverage the information from UMIs have yet to be formalized. In particular, sequencing errors in the U …
Mitophagy defect mediates the aging-associated hallmarks in Hutchinson-Gilford progeria syndrome.
Sun Y, Xu L, Li Y, Jia S, Wang G, Cen X, Xu Y, Cao Z, Wang J, Shen N, Hu L, Zhang J, Mao J, Xia H, Liu Z, Fu X. Sun Y, et al. Aging Cell. 2024 Jun;23(6):e14143. doi: 10.1111/acel.14143. Epub 2024 Mar 14. Aging Cell. 2024. PMID: 38482753 Free PMC article.
Mechanistically, we discovered that mitophagy affected the aging-associated phenotypes of HGPS-MSCs by inhibiting the STING-NF-qB pathway and the downstream transcription of senescence-associated secretory phenotypes (SASPs). Furthermore, by utilizing UMI-77, an effective …
Mechanistically, we discovered that mitophagy affected the aging-associated phenotypes of HGPS-MSCs by inhibiting the STING-NF-qB pathway an …
High-accuracy long-read amplicon sequences using unique molecular identifiers with Nanopore or PacBio sequencing.
Karst SM, Ziels RM, Kirkegaard RH, Sørensen EA, McDonald D, Zhu Q, Knight R, Albertsen M. Karst SM, et al. Nat Methods. 2021 Feb;18(2):165-169. doi: 10.1038/s41592-020-01041-y. Epub 2021 Jan 11. Nat Methods. 2021. PMID: 33432244
We applied our approach to sequence ribosomal RNA operon amplicons (~4,500 bp) and genomic sequences (>10,000 bp) of reference microbial communities in which we observed a chimera rate <0.02%. To reach a mean UMI consensus error rate <0.01%, a UMI read cove …
We applied our approach to sequence ribosomal RNA operon amplicons (~4,500 bp) and genomic sequences (>10,000 bp) of reference microbial …
Novel mitophagy inducer alleviates lupus nephritis by reducing myeloid cell activation and autoantigen presentation.
Wang H, Shen M, Ma Y, Lan L, Jiang X, Cen X, Guo G, Zhou Q, Yuan M, Chen J, Xia H, Xiao L, Han F. Wang H, et al. Kidney Int. 2024 Apr;105(4):759-774. doi: 10.1016/j.kint.2023.12.017. Epub 2024 Jan 29. Kidney Int. 2024. PMID: 38296028 Free article.
UMI-77 also restored mitochondrial function and attenuated proinflammatory phenotypes in lupus DCs. Adoptive transfer of DCs from MRL/lpr mice augmented serum anti-dsDNA IgG, urine protein and T-cell infiltration of the kidney in MRL/MpJ mice, which could be prevented by e …
UMI-77 also restored mitochondrial function and attenuated proinflammatory phenotypes in lupus DCs. Adoptive transfer of DCs from MRL …
Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model.
Cen X, Chen Y, Xu X, Wu R, He F, Zhao Q, Sun Q, Yi C, Wu J, Najafov A, Xia H. Cen X, et al. Nat Commun. 2020 Nov 12;11(1):5731. doi: 10.1038/s41467-020-19547-6. Nat Commun. 2020. PMID: 33184293 Free PMC article.
Here, we screen a library of 2024 FDA-approved drugs or drug candidates, revealing UMI-77 as an unexpected mitophagy activator. UMI-77 is an established BH3-mimetic for MCL-1 and was developed to induce apoptosis in cancer cells. ...Finally, we found that UMI …
Here, we screen a library of 2024 FDA-approved drugs or drug candidates, revealing UMI-77 as an unexpected mitophagy activator. UM …
Study on the Mechanism of UMI-77 in the Treatment of Sepsis-Induced Acute Lung Injury Based on Transcriptomics and Metabolomics.
Zhang J, Xia Z, Dong C, Zhu J, Ni H, Xu Y, Xu Y. Zhang J, et al. J Inflamm Res. 2024 Dec 18;17:11197-11209. doi: 10.2147/JIR.S495512. eCollection 2024. J Inflamm Res. 2024. PMID: 39713715 Free PMC article.
METHODS: This study aimed to delineate the mechanism by which UMI-77 counteracts sepsis-induced ALI using comprehensive transcriptomic and metabolomic analyses. RESULTS: UMI-77 significantly ameliorated histopathological changes in the lungs of mice with sepsis-indu …
METHODS: This study aimed to delineate the mechanism by which UMI-77 counteracts sepsis-induced ALI using comprehensive transcriptomi …
Demystifying "drop-outs" in single-cell UMI data.
Kim TH, Zhou X, Chen M. Kim TH, et al. Genome Biol. 2020 Aug 6;21(1):196. doi: 10.1186/s13059-020-02096-y. Genome Biol. 2020. PMID: 32762710 Free PMC article.
Many existing pipelines for scRNA-seq data apply pre-processing steps such as normalization or imputation to account for excessive zeros or "drop-outs." Here, we extensively analyze diverse UMI data sets to show that clustering should be the foremost step of the workflow. …
Many existing pipelines for scRNA-seq data apply pre-processing steps such as normalization or imputation to account for excessive zeros or …
UMI-77 Modulates the Complement Cascade Pathway and Inhibits Inflammatory Factor Storm in Sepsis Based on TMT Proteomics and Inflammation Array Glass Chip.
Xu Y, Chen Q, Jiang Y, Liang X, Wang T, Xu Y. Xu Y, et al. J Proteome Res. 2023 Nov 3;22(11):3464-3474. doi: 10.1021/acs.jproteome.3c00317. Epub 2023 Oct 13. J Proteome Res. 2023. PMID: 37830896
Sepsis is a systemic inflammatory response syndrome caused by infection, which has no specific drug at present. UMI-77 can significantly improve the survival rate of septic mice; the detailed role of UMI-77 and its underlying mechanisms in sepsis are not clear. Infl …
Sepsis is a systemic inflammatory response syndrome caused by infection, which has no specific drug at present. UMI-77 can significan …
2,794 results