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USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer.
Ren Y, Feng M, Hao X, Liu X, Li J, Li P, Gao J, Qi Q, Du L, Wang C, Wang Q, Wang Y. Ren Y, et al. Cancer Res. 2023 Apr 4;83(7):1074-1093. doi: 10.1158/0008-5472.CAN-22-1812. Cancer Res. 2023. PMID: 36607699
USP48 promoted pyroptosis by stabilizing gasdermin E (GSDME). USP48 bound GSDME and removed K48-linked ubiquitination at positions K120 and K189. ...SIGNIFICANCE: USP48 promotes pyroptosis by deubiquitinating GSDME and enhances antitumor immunity, indicating
USP48 promoted pyroptosis by stabilizing gasdermin E (GSDME). USP48 bound GSDME and removed K48-linked ubiquitination at posit
USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
Du L, Li Y, Kang M, Feng M, Ren Y, Dai H, Wang Y, Wang Y, Tang B. Du L, et al. Cancer Res. 2021 Jul 15;81(14):3822-3834. doi: 10.1158/0008-5472.CAN-20-4163. Epub 2021 Apr 26. Cancer Res. 2021. PMID: 33903120
However, the role of USP48 in HCC tumorigenesis remains unknown. In this study, we report that expression of USP48 is downregulated in diethylnitrosamine-induced liver tumorigenesis in mice as well as in human HCC. ...Moreover, methyltransferase-like 14 (Mettl14)-in …
However, the role of USP48 in HCC tumorigenesis remains unknown. In this study, we report that expression of USP48 is downregu …
USP48 Sustains Chemoresistance and Metastasis in Ovarian Cancer.
Lei X, Li X, Chen H, Liu Z. Lei X, et al. Curr Cancer Drug Targets. 2020;20(9):689-699. doi: 10.2174/1568009620666200503045400. Curr Cancer Drug Targets. 2020. PMID: 32359336
BACKGROUND: Ubiquitin specific protease 48 (USP48) is a member of the deubiquitinating enzymes (DUBs) family. ...CONCLUSION: In summary, USP48 may be a potential therapeutic target for ovarian cancer patients....
BACKGROUND: Ubiquitin specific protease 48 (USP48) is a member of the deubiquitinating enzymes (DUBs) family. ...CONCLUSION: In summa …
Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders.
Kitamura H. Kitamura H. Int J Mol Sci. 2023 Feb 6;24(4):3219. doi: 10.3390/ijms24043219. Int J Mol Sci. 2023. PMID: 36834633 Free PMC article. Review.
USP9X, 14, 17, and 20 in vascular cells are postulated to be determinants of atherosclerosis. Moreover, mutations in the Usp8 and Usp48 loci in pituitary tumors cause Cushing syndrome. This review summarizes the current knowledge about the modulatory roles of USPs in energ …
USP9X, 14, 17, and 20 in vascular cells are postulated to be determinants of atherosclerosis. Moreover, mutations in the Usp8 and Usp48
USP48 alleviates bone cancer pain and regulates MrgC stabilization in spinal cord neurons of male mice.
Yu J, Hou B, Huang Y, Wang X, Qian Y, Liang Y, Gu X, Ma Z, Sun Y. Yu J, et al. Eur J Pain. 2023 Jul;27(6):723-734. doi: 10.1002/ejp.2102. Epub 2023 Mar 15. Eur J Pain. 2023. PMID: 36864656
Overexpression and knockdown of USP48 were conducted in N2a cells to investigate the effect of USP48 on MrgC receptor number and ubiquitination. ...USP48 interacted with MrgC and overexpression of USP48 altered the level of ubiquitination of MrgC. ...
Overexpression and knockdown of USP48 were conducted in N2a cells to investigate the effect of USP48 on MrgC receptor number a …
USP48/USP31 Is a Nuclear Deubiquitinase that Potently Regulates Synapse Remodeling.
Ma Q, Ruan H, Dai H, Yao WD. Ma Q, et al. bioRxiv [Preprint]. 2023 Sep 21:2023.09.19.558317. doi: 10.1101/2023.09.19.558317. bioRxiv. 2023. PMID: 37781625 Free PMC article. Preprint.
USP48 is expressed primarily during the first postnatal week in the rodent brain and is virtually restricted to nuclei, mediated by a conserved, 13-amino acid nuclear localization signal. ...Depleting NF-kappaB prevents USP48-dependent spine pruning. These findings
USP48 is expressed primarily during the first postnatal week in the rodent brain and is virtually restricted to nuclei, mediated by a
USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection.
Jantaree P, Chaithongyot S, Sokolova O, Naumann M. Jantaree P, et al. Cell Mol Life Sci. 2022 Aug 1;79(8):461. doi: 10.1007/s00018-022-04489-7. Cell Mol Life Sci. 2022. PMID: 35913642 Free PMC article.
An important role of A20 is the suppression of caspase-8 activity and apoptotic cell death. USP48 thus enhances the activity of A20 to reduce apoptotic cell death in cells infected with H. pylori. Our results, therefore, define a synergistic mechanism by which USP48
An important role of A20 is the suppression of caspase-8 activity and apoptotic cell death. USP48 thus enhances the activity of A20 t …
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.
Sánchez-Bellver L, Férriz-Gordillo A, Carrillo-Pz M, Rabanal L, Garcia-Gonzalo FR, Marfany G. Sánchez-Bellver L, et al. Int J Mol Sci. 2022 Oct 19;23(20):12527. doi: 10.3390/ijms232012527. Int J Mol Sci. 2022. PMID: 36293380 Free PMC article.
In this work, we describe that a pool of endogenous USP48 localises to the basal body in retinal cells and provide data that supports the function of USP48 in the photoreceptor cilium. We also demonstrate that USP48 interacts with the IRD-associated proteins …
In this work, we describe that a pool of endogenous USP48 localises to the basal body in retinal cells and provide data that supports …
USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B.
Antao AM, Kaushal K, Das S, Singh V, Suresh B, Kim KS, Ramakrishna S. Antao AM, et al. Int J Mol Sci. 2021 Aug 7;22(16):8508. doi: 10.3390/ijms22168508. Int J Mol Sci. 2021. PMID: 34445214 Free PMC article.
Here, we report that USP48 interacts with and stabilizes the Aurora B protein. Furthermore, we showed that the deubiquitinating activity of USP48 helps to maintain the steady-state levels of Aurora B protein by regulating its half-life. Finally, USP48 knockou …
Here, we report that USP48 interacts with and stabilizes the Aurora B protein. Furthermore, we showed that the deubiquitinating activ …
Synthesis and structure-activity relationships of USP48 deubiquitinylase inhibitors.
Böhm K, Schulze-Niemand E, Kähne T, Siddiqui E, Täger C, Ramsbeck D, Buchholz M, Naumann M. Böhm K, et al. Arch Pharm (Weinheim). 2023 Jul;356(7):e2200661. doi: 10.1002/ardp.202200661. Epub 2023 May 17. Arch Pharm (Weinheim). 2023. PMID: 37196427
Nonetheless, a crystal structure of USP48 has not yet been resolved and potent inhibitors are not known. ...A compound containing a carboxylic acid functionalization (17e) inhibited USP48 activity toward tetra-ubiquitin rhodamine110 with an IC(50) of 12.6 M. ...
Nonetheless, a crystal structure of USP48 has not yet been resolved and potent inhibitors are not known. ...A compound containing a c …
72 results