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Structure and stereochemistry of the active metabolite of clopidogrel.
Pereillo JM, Maftouh M, Andrieu A, Uzabiaga MF, Fedeli O, Savi P, Pascal M, Herbert JM, Maffrand JP, Picard C. Pereillo JM, et al. Among authors: uzabiaga mf. Drug Metab Dispos. 2002 Nov;30(11):1288-95. doi: 10.1124/dmd.30.11.1288. Drug Metab Dispos. 2002. PMID: 12386137
The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts.
Savi P, Zachayus JL, Delesque-Touchard N, Labouret C, Hervé C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P, Herbert JM. Savi P, et al. Among authors: uzabiaga mf. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11069-74. doi: 10.1073/pnas.0510446103. Epub 2006 Jul 11. Proc Natl Acad Sci U S A. 2006. PMID: 16835302 Free PMC article.