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Year Number of Results
1976 1
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1989 1
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1995 3
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1999 2
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2003 3
2004 3
2005 4
2006 5
2007 8
2008 4
2009 7
2010 7
2011 5
2012 5
2013 11
2014 4
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308 results

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Page 1
Selective Inhibition of Na(V)1.8 with VX-548 for Acute Pain.
Jones J, Correll DJ, Lechner SM, Jazic I, Miao X, Shaw D, Simard C, Osteen JD, Hare B, Beaton A, Bertoch T, Buvanendran A, Habib AS, Pizzi LJ, Pollak RA, Weiner SG, Bozic C, Negulescu P, White PF; VX21-548-101 and VX21-548-102 Trial Groups. Jones J, et al. N Engl J Med. 2023 Aug 3;389(5):393-405. doi: 10.1056/NEJMoa2209870. N Engl J Med. 2023. PMID: 37530822 Clinical Trial.
BACKGROUND: The Na(V)1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548, an oral, highly selective inhibitor of Na(V)1.8, on control of acute pain is being studied. ME …
BACKGROUND: The Na(V)1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting noci …
Evidence-based guidelines for the pharmacological treatment of migraine, summary version.
Ornello R, Caponnetto V, Ahmed F, Al-Khazali HM, Ambrosini A, Ashina S, Baraldi C, Bellotti A, Brighina F, Calabresi P, Casillo F, Cevoli S, Cheng S, Chiang CC, Chiarugi A, Christensen RH, Chu MK, Coppola G, Corbelli I, Crema S, De Icco R, De Tommaso M, Di Lorenzo C, Di Stefano V, Diener HC, Ekizoglu E, Fallacara A, Favoni V, Garces KN, Geppetti P, Goicochea MT, Granato A, Granella F, Guerzoni S, Ha WS, Hassan A, Hirata K, Hoffmann J, Hüssler EM, Hussein M, Iannone LF, Jenkins B, Labastida-Ramirez A, Laporta A, Levin M, Lupica A, Mampreso E, Martinelli D, Monteith TS, Orologio I, Özge A, Pan LH, Panneerchelvam LL, Peres MF, Souza MNP, Pozo-Rosich P, Prudenzano MP, Quattrocchi S, Rainero I, Romanenko V, Romozzi M, Russo A, Sances G, Sarchielli P, Schwedt TJ, Silvestro M, Swerts DB, Tassorelli C, Tessitore A, Togha M, Vaghi G, Wang SJ, Ashina M, Sacco S. Ornello R, et al. Cephalalgia. 2025 Apr;45(4):3331024251321500. doi: 10.1177/03331024251321500. Epub 2025 Apr 25. Cephalalgia. 2025. PMID: 40277321 Free article.
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
GBD 2021 Diseases and Injuries Collaborators. GBD 2021 Diseases and Injuries Collaborators. Lancet. 2024 May 18;403(10440):2133-2161. doi: 10.1016/S0140-6736(24)00757-8. Epub 2024 Apr 17. Lancet. 2024. PMID: 38642570 Free PMC article.
Stroke genetics informs drug discovery and risk prediction across ancestries.
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, Rosand J, Sabatine MS, Sacco RL, Saleheen D, Sandset EC, Salomaa V, Sargurupremraj M, Sasaki M, Satizabal CL, Schmidt CO, Sh… See abstract for full author list ➔ Mishra A, et al. Nature. 2022 Nov;611(7934):115-123. doi: 10.1038/s41586-022-05165-3. Epub 2022 Sep 30. Nature. 2022. PMID: 36180795 Free PMC article.
Pain-causing stinging nettle toxins target TMEM233 to modulate Na(V)1.7 function.
Jami S, Deuis JR, Klasfauseweh T, Cheng X, Kurdyukov S, Chung F, Okorokov AL, Li S, Zhang J, Cristofori-Armstrong B, Israel MR, Ju RJ, Robinson SD, Zhao P, Ragnarsson L, Andersson Å, Tran P, Schendel V, McMahon KL, Tran HNT, Chin YK, Zhu Y, Liu J, Crawford T, Purushothamvasan S, Habib AM, Andersson DA, Rash LD, Wood JN, Zhao J, Stehbens SJ, Mobli M, Leffler A, Jiang D, Cox JJ, Waxman SG, Dib-Hajj SD, Neely GG, Durek T, Vetter I. Jami S, et al. Nat Commun. 2023 Apr 28;14(1):2442. doi: 10.1038/s41467-023-37963-2. Nat Commun. 2023. PMID: 37117223 Free PMC article.
Excelsatoxin A (ExTxA), a pain-causing knottin peptide from the Australian stinging tree Dendrocnide excelsa, is the first reported plant-derived Na(V) channel modulating peptide toxin. Here we show that TMEM233, a member of the dispanin family of transmembrane proteins ex …
Excelsatoxin A (ExTxA), a pain-causing knottin peptide from the Australian stinging tree Dendrocnide excelsa, is the first reported plant-de …
ADAPT NXT: Fixed Cycles or Every-Other-Week IV Efgartigimod in Generalized Myasthenia Gravis.
Habib AA, Claeys KG, Bril V, Hussain Y, Gwathmey K, Sahagian G, Cortés-Vicente E, Brauer E, Gelinas D, Sumbul A, Jimenez RH, Hristova D, Masschaele D, Mantegazza R, Meisel A, Attarian S; ADAPT NXT Study Group. Habib AA, et al. Ann Clin Transl Neurol. 2025 Jun;12(6):1162-1170. doi: 10.1002/acn3.70051. Epub 2025 Apr 14. Ann Clin Transl Neurol. 2025. PMID: 40223516 Free PMC article. Clinical Trial.
308 results