Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation.
Billingham LK, Stoolman JS, Vasan K, Rodriguez AE, Poor TA, Szibor M, Jacobs HT, Reczek CR, Rashidi A, Zhang P, Miska J, Chandel NS.
Billingham LK, et al.
Nat Immunol. 2022 May;23(5):692-704. doi: 10.1038/s41590-022-01185-3. Epub 2022 Apr 28.
Nat Immunol. 2022.
PMID: 35484407
Free PMC article.
Here, we report that mitochondrial electron transport chain (ETC) complex I, II, III and V inhibitors all prevent NLRP3 inflammasome activation. Ectopic expression of Saccharomyces cerevisiae NADH dehydrogenase (NDI1) or Ciona intestinalis alternative oxidase, which can co …
Here, we report that mitochondrial electron transport chain (ETC) complex I, II, III and V inhibitors all prevent NLRP3 inflammasome …