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40 results

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Page 1
Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation.
Hollunder B, Ostrem JL, Sahin IA, Rajamani N, Oxenford S, Butenko K, Neudorfer C, Reinhardt P, Zvarova P, Polosan M, Akram H, Vissani M, Zhang C, Sun B, Navratil P, Reich MM, Volkmann J, Yeh FC, Baldermann JC, Dembek TA, Visser-Vandewalle V, Alho EJL, Franceschini PR, Nanda P, Finke C, Kühn AA, Dougherty DD, Richardson RM, Bergman H, DeLong MR, Mazzoni A, Romito LM, Tyagi H, Zrinzo L, Joyce EM, Chabardes S, Starr PA, Li N, Horn A. Hollunder B, et al. Among authors: rajamani n. Nat Neurosci. 2024 Mar;27(3):573-586. doi: 10.1038/s41593-024-01570-1. Epub 2024 Feb 22. Nat Neurosci. 2024. PMID: 38388734 Free PMC article.
A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.
Hollunder B, Meyer GM, Li N, Reinhardt P, Sahin IA, Rajamani N, Pijar J, Nombela C, Mosley P, Acevedo N, Johnson KA, Provenza N, Akram H, Borron BM, Chou T, Germann J, Castaño Montoya JP, Strange B, Barcia JA, Tyagi H, Castle DJ, Rossell S, Bosanac P, Finke C, Kühn AA, Servello D, Bona AR, Porta M, Mogilner AY, Pourfar MH, Ostrem JL, Kuhn J, Visser-Vandewalle V, Chabardes S, Sheth SA, Goodman WK, Smith AH, Choi KS, Kopell BH, Mayberg HS, Figee M, Foltynie T, Limousin P, Ackermans L, de Jong JJA, Leentjens AFG, Butson CR, Okun MS, Richardson RM, Cosgrove GR, Dougherty DD, Siddiqi SH, Lozano AM, Zrinzo L, Joyce E, Polosan M, Neudorfer C, Baldermann JC, Fox MD, Horn A. Hollunder B, et al. Among authors: rajamani n. medRxiv [Preprint]. 2025 Dec 15:2025.12.14.25342121. doi: 10.64898/2025.12.14.25342121. medRxiv. 2025. PMID: 41445619 Free PMC article. Preprint.
Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application.
Neudorfer C, Al-Fatly B, Hollunder B, Li N, Meyer GM, Rajamani N, Butenko K, Vissani M, Bush A, Sisterson ND, Tadayon E, Schaper F, Bahners B, Hart L, Madan S, Pijar J, Mosley P, Akram H, Acevedo N, Castle D, Rossell S, Bosanac P, Ostrem JL, Starr PA, Odekerken VJ, deBie RM, Barcia JA, Tyagi H, Sheth SA, Goodman WK, Visser-Vandewalle V, Figee M, Dougherty DD, Zrinzo L, Joyce E, Corp D, Joutsa J, Picht T, Faust K, Kühn AA, Ganos C, Scharf J, Klein C, Fox MD, Richardson RM, Horn A. Neudorfer C, et al. Among authors: rajamani n. medRxiv [Preprint]. 2025 Aug 12:2025.08.08.25333301. doi: 10.1101/2025.08.08.25333301. medRxiv. 2025. PMID: 40832435 Free PMC article. Preprint.
A sensitive fluorescence reporter for monitoring quorum sensing regulated protease production in Vibrio harveyi.
Rajamani S, Sayre RT. Rajamani S, et al. J Microbiol Methods. 2011 Feb;84(2):189-93. doi: 10.1016/j.mimet.2010.11.017. Epub 2010 Dec 1. J Microbiol Methods. 2011. PMID: 21129419
The M3CLPY fusion, with the addition of wild-type V. harveyi (BB120) cell-free culture filtrate showed a time-dependent loss in fluorescence resonance energy transfer (FRET) associated with the cleavage of the LuxP linker protein and hence separation of the two fluorophore …
The M3CLPY fusion, with the addition of wild-type V. harveyi (BB120) cell-free culture filtrate showed a time-dependent loss in fluor …
Discovery of new indole-based acylsulfonamide Na(v)1.7 inhibitors.
Wu YJ, Venables B, Guernon J, Chen J, Sit SY, Rajamani R, Knox RJ, Matchett M, Pieschl RL, Herrington J, Bristow LJ, Meanwell NA, Thompson LA, Dzierba C. Wu YJ, et al. Among authors: rajamani r. Bioorg Med Chem Lett. 2019 Feb 15;29(4):659-663. doi: 10.1016/j.bmcl.2018.12.013. Epub 2018 Dec 6. Bioorg Med Chem Lett. 2019. PMID: 30638874
Screening of 100 acylsulfonamides from the Bristol-Myers Squibb compound collection identified the C3-cyclohexyl indole 6 as a potent Na(v)1.7 inhibitor. Replacement of the C2 furanyl ring of 6 with a heteroaryl moiety or truncation of this group led to the identification …
Screening of 100 acylsulfonamides from the Bristol-Myers Squibb compound collection identified the C3-cyclohexyl indole 6 as a potent Na( …
Recent updates on drug resistance in Mycobacterium tuberculosis.
Singh R, Dwivedi SP, Gaharwar US, Meena R, Rajamani P, Prasad T. Singh R, et al. Among authors: rajamani p. J Appl Microbiol. 2020 Jun;128(6):1547-1567. doi: 10.1111/jam.14478. Epub 2019 Oct 29. J Appl Microbiol. 2020. PMID: 31595643 Review.
Several reasons account for the failure of TB therapy such as (i) late diagnosis, (ii) lack of timely and proper administration of effective drugs, (iii) lower availability of less toxic, inexpensive and effective drugs, (iv) long treatment duration, (v) nonadherence to dr …
Several reasons account for the failure of TB therapy such as (i) late diagnosis, (ii) lack of timely and proper administration of effective …
A Functional Na(V)1.7-Na(V)Ab Chimera with a Reconstituted High-Affinity ProTx-II Binding Site.
Rajamani R, Wu S, Rodrigo I, Gao M, Low S, Megson L, Wensel D, Pieschl RL, Post-Munson DJ, Watson J, Langley DR, Ahlijanian MK, Bristow LJ, Herrington J. Rajamani R, et al. Mol Pharmacol. 2017 Sep;92(3):310-317. doi: 10.1124/mol.117.108712. Epub 2017 Jun 23. Mol Pharmacol. 2017. PMID: 28645932
The Na(V)1.7 voltage-gated sodium channel is implicated in human pain perception by genetics. ...Hence, agents that specifically modulate the function of Na(V)1.7 have the potential to yield novel therapeutics to treat pain. The complexity of the channel and the cha …
The Na(V)1.7 voltage-gated sodium channel is implicated in human pain perception by genetics. ...Hence, agents that specifically modu …
Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.
Hollunder B, Ostrem JL, Sahin IA, Rajamani N, Oxenford S, Butenko K, Neudorfer C, Reinhardt P, Zvarova P, Polosan M, Akram H, Vissani M, Zhang C, Sun B, Navratil P, Reich MM, Volkmann J, Yeh FC, Baldermann JC, Dembek TA, Visser-Vandewalle V, Alho EJL, Franceschini PR, Nanda P, Finke C, Kühn AA, Dougherty DD, Richardson RM, Bergman H, DeLong MR, Mazzoni A, Romito LM, Tyagi H, Zrinzo L, Joyce EM, Chabardes S, Starr PA, Li N, Horn A. Hollunder B, et al. Among authors: rajamani n. medRxiv [Preprint]. 2023 Aug 25:2023.03.07.23286766. doi: 10.1101/2023.03.07.23286766. medRxiv. 2023. Update in: Nat Neurosci. 2024 Mar;27(3):573-586. doi: 10.1038/s41593-024-01570-1. PMID: 36945497 Free PMC article. Updated. Preprint.
Discovery of morpholine-based aryl sulfonamides as Na(v)1.7 inhibitors.
Wu YJ, Guernon J, McClure A, Venables B, Rajamani R, Robbins KJ, Knox RJ, Matchett M, Pieschl RL, Herrington J, Bristow LJ, Meanwell NA, Olson R, Thompson LA, Dzierba C. Wu YJ, et al. Among authors: rajamani r. Bioorg Med Chem Lett. 2018 Mar 1;28(5):958-962. doi: 10.1016/j.bmcl.2018.01.035. Epub 2018 Feb 1. Bioorg Med Chem Lett. 2018. PMID: 29439904
Replacement of the piperidine ring in the lead benzenesulfonamide Na(v)1.7 inhibitor 1 with a weakly basic morpholine core resulted in a significant reduction in Na(v)1.7 inhibitory activity, but the activity was restored by shortening the linkage from methyleneoxy …
Replacement of the piperidine ring in the lead benzenesulfonamide Na(v)1.7 inhibitor 1 with a weakly basic morpholine core resulted i …
40 results