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Drug binding assays do not reveal specific binding of lacosamide to collapsin response mediator protein 2 (CRMP-2).
Wolff C, Carrington B, Varrin-Doyer M, Vandendriessche A, Van der Perren C, Famelart M, Gillard M, Foerch P, Rogemond V, Honnorat J, Lawson A, Miller K. Wolff C, et al. Among authors: van der perren c. CNS Neurosci Ther. 2012 Jun;18(6):493-500. doi: 10.1111/j.1755-5949.2012.00313.x. CNS Neurosci Ther. 2012. PMID: 22672303 Free PMC article.
Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain.
Mingorance-Le Meur A, Ghisdal P, Mullier B, De Ron P, Downey P, Van Der Perren C, Declercq V, Cornelis S, Famelart M, Van Asperen J, Jnoff E, Courade JP. Mingorance-Le Meur A, et al. Among authors: van der perren c. Br J Pharmacol. 2013 Nov;170(5):1053-63. doi: 10.1111/bph.12343. Br J Pharmacol. 2013. PMID: 23962079 Free PMC article.