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Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells.

West MD, Chang CF, Larocca D, Li J, Jiang J, Sim P, Labat I, Chapman KB, Wong KE, Nicoll J, Van Kanegan MJ, de Grey ADNJ, Nasonkin IO, Stahl A, Sternberg H. West MD, et al. Among authors: van kanegan mj. Stem Cell Res Ther. 2019 Jan 8;10(1):7. doi: 10.1186/s13287-018-1087-7. Stem Cell Res Ther. 2019. PMID: 30616682 Free PMC article.

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Initial Assessment of Variability of Responses to Toxicants in Donor-Specific Endothelial Colony Forming Cells.

Filonov D, Tice R, Luo R, Grotegut C, Van Kanegan MJ, Ludlow JW, Il'yasova D, Kinev A. Filonov D, et al. Among authors: van kanegan mj. Front Public Health. 2018 Dec 21;6:369. doi: 10.3389/fpubh.2018.00369. eCollection 2018. Front Public Health. 2018. PMID: 30622937 Free PMC article.

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SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.

Quinti L, Casale M, Moniot S, Pais TF, Van Kanegan MJ, Kaltenbach LS, Pallos J, Lim RG, Naidu SD, Runne H, Meisel L, Rauf NA, Leyfer D, Maxwell MM, Saiah E, Landers JE, Luthi-Carter R, Abagyan R, Dinkova-Kostova AT, Steegborn C, Marsh JL, Lo DC, Thompson LM, Kazantsev AG. Quinti L, et al. Among authors: van kanegan mj. Cell Chem Biol. 2016 Jul 21;23(7):849-861. doi: 10.1016/j.chembiol.2016.05.015. Epub 2016 Jul 14. Cell Chem Biol. 2016. PMID: 27427231 Free article.

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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.

Quinti L, Dayalan Naidu S, Träger U, Chen X, Kegel-Gleason K, Llères D, Connolly C, Chopra V, Low C, Moniot S, Sapp E, Tousley AR, Vodicka P, Van Kanegan MJ, Kaltenbach LS, Crawford LA, Fuszard M, Higgins M, Miller JRC, Farmer RE, Potluri V, Samajdar S, Meisel L, Zhang N, Snyder A, Stein R, Hersch SM, Ellerby LM, Weerapana E, Schwarzschild MA, Steegborn C, Leavitt BR, Degterev A, Tabrizi SJ, Lo DC, DiFiglia M, Thompson LM, Dinkova-Kostova AT, Kazantsev AG. Quinti L, et al. Among authors: van kanegan mj. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4676-E4685. doi: 10.1073/pnas.1614943114. Epub 2017 May 22. Proc Natl Acad Sci U S A. 2017. PMID: 28533375 Free PMC article.

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BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin.

Van Kanegan MJ, He DN, Dunn DE, Yang P, Newman RA, West AE, Lo DC. Van Kanegan MJ, et al. J Neurosci. 2014 Jan 15;34(3):963-8. doi: 10.1523/JNEUROSCI.2700-13.2014. J Neurosci. 2014. PMID: 24431454 Free PMC article.

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Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

Van Kanegan MJ, Dunn DE, Kaltenbach LS, Shah B, He DN, McCoy DD, Yang P, Peng J, Shen L, Du L, Cichewicz RH, Newman RA, Lo DC. Van Kanegan MJ, et al. Sci Rep. 2016 May 12;6:25626. doi: 10.1038/srep25626. Sci Rep. 2016. PMID: 27172999 Free PMC article.

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Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.

Christensen DJ, Ohkubo N, Oddo J, Van Kanegan MJ, Neil J, Li F, Colton CA, Vitek MP. Christensen DJ, et al. Among authors: van kanegan mj. J Immunol. 2011 Feb 15;186(4):2535-42. doi: 10.4049/jimmunol.1002847. J Immunol. 2011. PMID: 21289314 Free article.

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Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt.

Van Kanegan MJ, Adams DG, Wadzinski BE, Strack S. Van Kanegan MJ, et al. J Biol Chem. 2005 Oct 28;280(43):36029-36. doi: 10.1074/jbc.M506986200. Epub 2005 Aug 28. J Biol Chem. 2005. PMID: 16129692 Free article.

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The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation.

Van Kanegan MJ, Strack S. Van Kanegan MJ, et al. Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24. Mol Cell Biol. 2009. PMID: 19029245 Free PMC article.

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PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis.

Dickey AS, Sanchez DN, Arreola M, Sampat KR, Fan W, Arbez N, Akimov S, Van Kanegan MJ, Ohnishi K, Gilmore-Hall SK, Flores AL, Nguyen JM, Lomas N, Hsu CL, Lo DC, Ross CA, Masliah E, Evans RM, La Spada AR. Dickey AS, et al. Among authors: van kanegan mj. Sci Transl Med. 2017 Dec 6;9(419):eaal2332. doi: 10.1126/scitranslmed.aal2332. Sci Transl Med. 2017. PMID: 29212711 Free PMC article.

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