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2010 2
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2012 4
2013 1
2022 0
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Page 1
Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem.
Hanson KL, VandenBrink BM, Babu KN, Allen KE, Nelson WL, Kunze KL. Hanson KL, et al. Among authors: vandenbrink bm. Drug Metab Dispos. 2010 Jun;38(6):963-72. doi: 10.1124/dmd.110.032391. Epub 2010 Mar 3. Drug Metab Dispos. 2010. PMID: 20200233 Free PMC article.
Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme.
Henne KR, Tran TB, VandenBrink BM, Rock DA, Aidasani DK, Subramanian R, Mason AK, Stresser DM, Teffera Y, Wong SG, Johnson MG, Chen X, Tonn GR, Wong BK. Henne KR, et al. Among authors: vandenbrink bm. Drug Metab Dispos. 2012 Jul;40(7):1429-40. doi: 10.1124/dmd.112.045708. Epub 2012 Apr 19. Drug Metab Dispos. 2012. PMID: 22517972