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Silybin is metabolized by cytochrome P450 2C8 in vitro.
Jancová P, Anzenbacherová E, Papousková B, Lemr K, Luzná P, Veinlichová A, Anzenbacher P, Simánek V. Jancová P, et al. Among authors: veinlichova a. Drug Metab Dispos. 2007 Nov;35(11):2035-9. doi: 10.1124/dmd.107.016410. Epub 2007 Aug 1. Drug Metab Dispos. 2007. PMID: 17670841
In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450.
Anzenbacherová E, Anzenbacher P, Zídek Z, Buchar E, Kmoníčková E, Potmesil P, Nekvindová J, Veinlichová A, Holý A. Anzenbacherová E, et al. Among authors: veinlichova a. Physiol Res. 2008;57(5):761-768. doi: 10.33549/physiolres.931319. Epub 2007 Oct 11. Physiol Res. 2008. PMID: 17949244 Free article.