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Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments.

Talwelkar SS, Mäyränpää MI, Søraas L, Potdar S, Bao J, Hemmes A, Linnavirta N, Lømo J, Räsänen J, Knuuttila A, Wennerberg K, Verschuren EW. Talwelkar SS, et al. Among authors: verschuren ew. Cell Rep Med. 2021 Aug 17;2(8):100373. doi: 10.1016/j.xcrm.2021.100373. eCollection 2021 Aug 17. Cell Rep Med. 2021. PMID: 34467250 Free PMC article.

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Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin.

Tervonen TA, Pant SM, Belitškin D, Englund JI, Närhi K, Haglund C, Kovanen PE, Verschuren EW, Klefström J. Tervonen TA, et al. Among authors: verschuren ew. Cancer Res. 2021 Mar 15;81(6):1513-1527. doi: 10.1158/0008-5472.CAN-20-1760. Epub 2021 Jan 18. Cancer Res. 2021. PMID: 33461973

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More than a Tumor Suppressor: E-Cadherin Loss Drives Lung Cancer Metastasis.

Devlin JR, Verschuren EW. Devlin JR, et al. Among authors: verschuren ew. Am J Respir Cell Mol Biol. 2018 Aug;59(2):141-142. doi: 10.1165/rcmb.2018-0063ED. Am J Respir Cell Mol Biol. 2018. PMID: 29688752 No abstract available.

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SOX9 has distinct roles in the formation and progression of different non-small cell lung cancer histotypes.

Bao J, Närhi K, Teodòsio A, Hemmes A, Linnavirta NM, Mäyränpää MI, Salmenkivi K, Le Quesne J, Verschuren EW. Bao J, et al. Among authors: verschuren ew. J Pathol. 2021 Sep;255(1):16-29. doi: 10.1002/path.5733. Epub 2021 Jun 19. J Pathol. 2021. PMID: 34021911

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The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin.

Verschuren EW, Jones N, Evan GI. Verschuren EW, et al. J Gen Virol. 2004 Jun;85(Pt 6):1347-1361. doi: 10.1099/vir.0.79812-0. J Gen Virol. 2004. PMID: 15166416 Review.

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Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing.

Nagaraj AS, Bao J, Hemmes A, Machado M, Närhi K, Verschuren EW. Nagaraj AS, et al. Among authors: verschuren ew. J Vis Exp. 2018 Nov 29;(141). doi: 10.3791/58569. J Vis Exp. 2018. PMID: 30582602

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Receptor Tyrosine Kinase Signaling Networks Define Sensitivity to ERBB Inhibition and Stratify Kras-Mutant Lung Cancers.

Talwelkar SS, Nagaraj AS, Devlin JR, Hemmes A, Potdar S, Kiss EA, Saharinen P, Salmenkivi K, Mäyränpää MI, Wennerberg K, Verschuren EW. Talwelkar SS, et al. Among authors: verschuren ew. Mol Cancer Ther. 2019 Oct;18(10):1863-1874. doi: 10.1158/1535-7163.MCT-18-0573. Epub 2019 Jul 18. Mol Cancer Ther. 2019. PMID: 31320402

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Spa-RQ: an Image Analysis Tool to Visualise and Quantify Spatial Phenotypes Applied to Non-Small Cell Lung Cancer.

Bao J, Walliander M, Kovács F, Nagaraj AS, Hemmes A, Sarhadi VK, Knuutila S, Lundin J, Horvath P, Verschuren EW. Bao J, et al. Among authors: verschuren ew. Sci Rep. 2019 Nov 26;9(1):17613. doi: 10.1038/s41598-019-54038-9. Sci Rep. 2019. PMID: 31772293 Free PMC article.

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Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project.

de Hoogt R, Estrada MF, Vidic S, Davies EJ, Osswald A, Barbier M, Santo VE, Gjerde K, van Zoggel HJAA, Blom S, Dong M, Närhi K, Boghaert E, Brito C, Chong Y, Sommergruber W, van der Kuip H, van Weerden WM, Verschuren EW, Hickman J, Graeser R. de Hoogt R, et al. Among authors: verschuren ew. Sci Data. 2017 Nov 21;4:170170. doi: 10.1038/sdata.2017.170. Sci Data. 2017. PMID: 29160867 Free PMC article.

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APC/C(Cdc20) targets E2F1 for degradation in prometaphase.

Peart MJ, Poyurovsky MV, Kass EM, Urist M, Verschuren EW, Summers MK, Jackson PK, Prives C. Peart MJ, et al. Among authors: verschuren ew. Cell Cycle. 2010 Oct 1;9(19):3956-64. doi: 10.4161/cc.9.19.13162. Epub 2010 Oct 26. Cell Cycle. 2010. PMID: 20948288 Free PMC article.

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