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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2000 1
2001 1
2002 1
2003 3
2004 1
2005 2
2006 3
2007 6
2008 5
2009 3
2010 1
2011 3
2012 3
2013 5
2014 6
2015 2
2016 1
2017 2
2018 1
2019 1
2021 0
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47 results
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Page 1
A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine.
DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. DeWire SM, et al. Among authors: violin jd. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17. doi: 10.1124/jpet.112.201616. Epub 2013 Jan 8. J Pharmacol Exp Ther. 2013. PMID: 23300227
Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.
Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS. Chen XT, et al. Among authors: violin jd. J Med Chem. 2013 Oct 24;56(20):8019-31. doi: 10.1021/jm4010829. Epub 2013 Oct 14. J Med Chem. 2013. PMID: 24063433
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers.
Soergel DG, Subach RA, Burnham N, Lark MW, James IE, Sadler BM, Skobieranda F, Violin JD, Webster LR. Soergel DG, et al. Among authors: violin jd. Pain. 2014 Sep;155(9):1829-1835. doi: 10.1016/j.pain.2014.06.011. Epub 2014 Jun 19. Pain. 2014. PMID: 24954166 Clinical Trial.
Biased ligands: pathway validation for novel GPCR therapeutics.
Rominger DH, Cowan CL, Gowen-MacDonald W, Violin JD. Rominger DH, et al. Among authors: violin jd. Curr Opin Pharmacol. 2014 Jun;16:108-15. doi: 10.1016/j.coph.2014.04.002. Epub 2014 May 14. Curr Opin Pharmacol. 2014. PMID: 24834870 Review.
GPCR biased ligands as novel heart failure therapeutics.
Violin JD, Soergel DG, Boerrigter G, Burnett JC Jr, Lark MW. Violin JD, et al. Trends Cardiovasc Med. 2013 Oct;23(7):242-9. doi: 10.1016/j.tcm.2013.01.002. Epub 2013 Mar 15. Trends Cardiovasc Med. 2013. PMID: 23499300 Review.
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