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Did you mean verma (33,790 results)?
VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.
Yue Y, Liu J, Cui X, Cao J, Luo G, Zhang Z, Cheng T, Gao M, Shu X, Ma H, Wang F, Wang X, Shen B, Wang Y, Feng X, He C, Liu J. Yue Y, et al. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018. Cell Discov. 2018. PMID: 29507755 Free PMC article.
Around 60% of VIRMA mRNA immunoprecipitation targets manifest strong m(6)A enrichment in 3'UTR. Depletions of VIRMA and METTL3 induce 3'UTR lengthening of several hundred mRNAs with over 50% targets in common. VIRMA associates with polyadenylation cleavage fa …
Around 60% of VIRMA mRNA immunoprecipitation targets manifest strong m(6)A enrichment in 3'UTR. Depletions of VIRMA and METTL3 …
VIRMA Facilitates Triple-Negative Breast Cancer Progression via Increasing m6A-Dependent KIF15 Expression.
Chen C, Wang Y, Li Y, Zhang C. Chen C, et al. Discov Med. 2023 Oct;35(178):787-795. doi: 10.24976/Discov.Med.202335178.73. Discov Med. 2023. PMID: 37811616 Free article.
BACKGROUND: Vir like N6-methyladenosine (m6A) methyltransferase associated protein (VIRMA) is associated with various tumors, but the specific role of VIRMA in triple-negative breast cancer (TNBC) and the mechanisms are still unclear. Thus, in this study, in additio …
BACKGROUND: Vir like N6-methyladenosine (m6A) methyltransferase associated protein (VIRMA) is associated with various tumors, but the …
Role of m6A methyltransferase component VIRMA in multiple human cancers (Review).
Zhu W, Wang JZ, Wei JF, Lu C. Zhu W, et al. Cancer Cell Int. 2021 Mar 17;21(1):172. doi: 10.1186/s12935-021-01868-1. Cancer Cell Int. 2021. PMID: 33731118 Free PMC article. Review.
The present review investigated the role of VIRMA in various types of cancer. In an m6A-dependent or -independent manner, VIRMA can play an oncogenic role by regulating cancer cell proliferation, migration and invasion, metastasis, apoptosis resistance and tumor gro …
The present review investigated the role of VIRMA in various types of cancer. In an m6A-dependent or -independent manner, VIRMA …
The role of m6A modification in the biological functions and diseases.
Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, Yang C, Chen Y. Jiang X, et al. Signal Transduct Target Ther. 2021 Feb 21;6(1):74. doi: 10.1038/s41392-020-00450-x. Signal Transduct Target Ther. 2021. PMID: 33611339 Free PMC article. Review.
N(6)-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m6A methyltransferases, or writers, such as METTL3/14/16, RBM15/15B, …
N(6)-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especia …
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
Wu M, Wu X, Sun H, Wang W, Zhang L, Liu X, Zhang Y, Zhang X, Liu J, Shen B, Zhou T. Wu M, et al. Sci Adv. 2025 Jun 27;11(26):eadq9643. doi: 10.1126/sciadv.adq9643. Epub 2025 Jun 27. Sci Adv. 2025. PMID: 40577453 Free PMC article.
Here, we demonstrate that VIRMA-mediated m(6)A modification is essential for active ribosome biogenesis. VIRMA depletion destabilizes the entire writer complex and reduces m(6)A levels, leading to decreased proliferation and increased apoptosis of neural progenitor/ …
Here, we demonstrate that VIRMA-mediated m(6)A modification is essential for active ribosome biogenesis. VIRMA depletion desta …
VIRMA facilitates intrahepatic cholangiocarcinoma progression through epigenetic augmentation of TMED2 and PARD3B mRNA stabilization.
Xu H, Lin X, Li Z, He X, Li Y, Qiu L, Lu L, Liu B, Zhan M, He K. Xu H, et al. J Gastroenterol. 2023 Sep;58(9):925-944. doi: 10.1007/s00535-023-02015-5. Epub 2023 Jun 30. J Gastroenterol. 2023. PMID: 37391589
RESULTS: VIRMA showed high expression in ICC tissues, and this finding predicted a dismal prognostic outcome. ...Thus, demonstrating VIRMA and its pathway as candidate therapeutic targets for ICC treatment....
RESULTS: VIRMA showed high expression in ICC tissues, and this finding predicted a dismal prognostic outcome. ...Thus, demonstrating …
Eosinophil extracellular traps drive T follicular helper cell differentiation via VIRMA-dependent MAF stabilization in bullous pemphigoid.
Shen S, Fang H, Li X, Zhou Y, Tang X, Miao H, Li L, Chen J, Xue K, Zhang C, Chu M, Pang B, Bai Y, Qiao H, Dang E, Shao S, Wang G. Shen S, et al. J Allergy Clin Immunol. 2025 Apr;155(4):1357-1370. doi: 10.1016/j.jaci.2024.09.030. Epub 2024 Oct 28. J Allergy Clin Immunol. 2025. PMID: 39490750
Additionally, we discovered that EETs induced the N(6)-methyladenosine methylation of the transcription factor musculoaponeurotic fibrosarcoma (MAF) via the DNA-CCDC25-VIRMA pathway, thereby enhancing its mRNA stability and promoting Tfh cell differentiation. CONCLUSION: O …
Additionally, we discovered that EETs induced the N(6)-methyladenosine methylation of the transcription factor musculoaponeurotic fibrosarco …
KIAA1429/VIRMA promotes breast cancer progression by m(6) A-dependent cytosolic HAS2 stabilization.
Li N, Zhu Z, Deng Y, Tang R, Hui H, Kang Y, Rana TM. Li N, et al. EMBO Rep. 2023 Oct 9;24(10):e55506. doi: 10.15252/embr.202255506. Epub 2023 Sep 14. EMBO Rep. 2023. PMID: 37705505 Free PMC article.
KIAA1429/VIRMA is mislocalized to the cytosol of breast cancer tissues and cell lines, and shRNA-mediated knockdown inhibits breast cancer cell proliferation, migration, and invasion. ...HAS2 mRNA and KIAA1429/VIRMA mRNA levels correlate positively in breast cancer …
KIAA1429/VIRMA is mislocalized to the cytosol of breast cancer tissues and cell lines, and shRNA-mediated knockdown inhibits breast c …
VIRMA contributes to non-small cell lung cancer progression via N(6)-methyladenosine-dependent DAPK3 post-transcriptional modification.
Xu Y, Chen Y, Yao Y, Xie H, Lu G, Du C, Cheng J, Zhou J. Xu Y, et al. Cancer Lett. 2021 Dec 1;522:142-154. doi: 10.1016/j.canlet.2021.08.027. Epub 2021 Sep 11. Cancer Lett. 2021. PMID: 34520821
Vir-Like m6A methyltransferase associated (VIRMA, also called KIAA1429) has not been well studied in NSCLC. Thus, in this study, we investigated the biological impact and underlying mechanism of VIRMA in NSCLC. ...Therefore, VIRMA may be a novel therapeutic t …
Vir-Like m6A methyltransferase associated (VIRMA, also called KIAA1429) has not been well studied in NSCLC. Thus, in this study, we i …
VIRMA promotes nasopharyngeal carcinoma, tumorigenesis, and metastasis by upregulation of E2F7 in an m6A-dependent manner.
Zheng ZQ, Huang ZH, Liang YL, Zheng WH, Xu C, Li ZX, Liu N, Yang PY, Li YQ, Ma J, Sun Y, Tang LL, Wei D. Zheng ZQ, et al. J Biol Chem. 2023 May;299(5):104677. doi: 10.1016/j.jbc.2023.104677. Epub 2023 Apr 5. J Biol Chem. 2023. PMID: 37028765 Free PMC article.
High VIRMA expression served as a prognostic biomarker and was associated with poor outcomes in patients with NPC. Mechanistically, VIRMA mediated the m6A methylation of E2F7 3'-UTR, then IGF2BP2 bound, and maintained the stability of E2F7 mRNA. ...
High VIRMA expression served as a prognostic biomarker and was associated with poor outcomes in patients with NPC. Mechanistically, …
142 results