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2017 1
2018 1
2019 1
2022 1
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Page 1
Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens.
Scarff JM, Waidyarachchi SL, Meyer CJ, Lane DJ, Chai W, Lemmon MM, Liu J, Butler MM, Bowlin TL, Lee RE, Panchal RG. Scarff JM, et al. Among authors: waidyarachchi sl. J Antibiot (Tokyo). 2019 Sep;72(9):693-701. doi: 10.1038/s41429-019-0194-8. Epub 2019 Jun 4. J Antibiot (Tokyo). 2019. PMID: 31164713 Free PMC article.
Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads.
Butler MM, Waidyarachchi SL, Shao J, Nguyen ST, Ding X, Cardinale SC, Morin LR, Kwasny SM, Ito M, Gezelle J, Jiminez-Di Az MB, Angulo-Barturen I, Jacobs RT, Burrows JN, Aron ZD, Bowlin TL, Desai SA. Butler MM, et al. Among authors: waidyarachchi sl. Mol Pharmacol. 2022 Jul 7:MOLPHARM-AR-2022-000549. doi: 10.1124/molpharm.122.000549. Online ahead of print. Mol Pharmacol. 2022. PMID: 35798366 Free article.
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.
Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, Böttger EC, Lenaerts AJ. Lee RE, et al. Among authors: waidyarachchi sl. Nat Med. 2014 Feb;20(2):152-158. doi: 10.1038/nm.3458. Epub 2014 Jan 26. Nat Med. 2014. PMID: 24464186 Free PMC article.
Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.
Liu J, Bruhn DF, Lee RB, Zheng Z, Janusic T, Scherbakov D, Scherman MS, Boshoff HI, Das S, Rakesh, Waidyarachchi SL, Brewer TA, Gracia B, Yang L, Bollinger J, Robertson GT, Meibohm B, Lenaerts AJ, Ainsa J, Böttger EC, Lee RE. Liu J, et al. Among authors: waidyarachchi sl. ACS Infect Dis. 2017 Jan 13;3(1):72-88. doi: 10.1021/acsinfecdis.6b00158. Epub 2016 Nov 11. ACS Infect Dis. 2017. PMID: 28081607 Free PMC article.
Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.
Bruhn DF, Waidyarachchi SL, Madhura DB, Shcherbakov D, Zheng Z, Liu J, Abdelrahman YM, Singh AP, Duscha S, Rathi C, Lee RB, Belland RJ, Meibohm B, Rosch JW, Böttger EC, Lee RE. Bruhn DF, et al. Among authors: waidyarachchi sl. Sci Transl Med. 2015 May 20;7(288):288ra75. doi: 10.1126/scitranslmed.3010572. Sci Transl Med. 2015. PMID: 25995221 Free PMC article.